Size and shape of the repetitive domain of high molecular weight wheat gluten proteins. 1. Small angle neutron scattering

The solution structure of the central repetitive domain of high molecular weight (HMW) wheat gluten proteins has been investigated for a range of concentrations and temperatures using mainly small-angle neutron scattering. A representative part of the repetitive domain (dBl) was studied as well as an "oligomer" basically consisting of four dBl units, which has a length similar to the complete central domain. The scattering data over the entire angular range of both proteins are in quantitative agreement with a structural model based on a worm-like chain, a model frequently used in polymer theory. This model describes the "supersecondary, structure" of dBl and dB4 as a semiflexible cylinder with a length of about 235 and 900 Angstrom, respectively, and a cross-sectional diameter of about 15 Angstrom. The flexibility of both proteins is characterized by a persistence length of about 13 Angstrom. Their structures are thus quantitatively identical, which implies that the central HMW domain can be elongated while retaining its structural characteristics. It seems conceivable that the flexible cylinder results from a helical structure, which resembles the beta-spiral observed in earlier studies on gluten proteins and elastin. However, compared to the previously, proposed structure of a (stiff) rod, our experiments clearly indicate flexibility of the cylinder. (C) 2003 Wiley Periodicals, Inc

Distribution of rRNA genes in breeds of domestic pig studied by non-radioactive in situ hybridization and selective silver-staining

Almost forty years after the enactment of Title VII, women\u27s struggle for equality in the workplace continues. Although Title VII was intended to “break[] down old patterns of segregation and hierarchy,” the American workplace remains largely gender-segregated. Indeed, more than one-third of all women workers are employed in occupations in which the percentage of women exceeds 80%. Even in disciplines in which women have made gains, top status (and top paying) jobs remain male-dominated while the lower status jobs are filled by women. This pattern of gender segregation, in turn, accounts for a substantial part of the persistent wage gap between men and women. As of the end of 2001, women working full-time still earned only seventy-six cents for every dollar earned by their male counterparts. Thus, we have not only the persistence of job segregation, but job segregation with particular implications for equality—men are on top and remain there. The central question addressed by this essay is “Why?” Why has gender segregation of the work force persisted so stubbornly in the face of Title VII and myriad state antidiscrimination statutes? This essay explores the relationship between our common understanding of discrimination and the continuation of gender segregation and suggests that the elimination of discrimination as it has been defined under Title VII might well leave undisturbed a significant amount of gender segregation, regarding it as a product of individual choice rather than workplace bias. This essay also explores the operation of this rhetoric of choice in specific examples from Title VII doctrine and turns to feminist critiques of the concept of individual choice or agency, suggesting that, although feminists have called into question assumptions about women\u27s agency under patriarchy, these critiques have been too limited in the Title VII context. The essay concludes by suggesting ways in which feminist critiques of agency might be brought to bear more effectively in a challenge to workplace segregation

Disturbed functional brain networks and neurocognitive function in low-grade glioma patients: a graph theoretical analysis of resting-state MEG

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The moment of truth for WIMP Dark Matter

We know that dark matter constitutes 85% of all the matter in the Universe, but we do not know of what it is made. Amongst the many Dark Matter candidates proposed, WIMPs (weakly interacting massive particles) occupy a special place, as they arise naturally from well motivated extensions of the standard model of particle physics. With the advent of the Large Hadron Collider at CERN, and a new generation of astroparticle experiments, the moment of truth has come for WIMPs: either we will discover them in the next five to ten years, or we will witness the inevitable decline of WIMP paradigm.Comment: To appear in Nature (Nov 18, 2010

Secular Evolution and the Formation of Pseudobulges in Disk Galaxies

We review internal processes of secular evolution in galaxy disks, concentrating on the buildup of dense central features that look like classical, merger-built bulges but that were made slowly out of disk gas. We call these pseudobulges. As an existence proof, we review how bars rearrange disk gas into outer rings, inner rings, and gas dumped into the center. In simulations, this gas reaches high densities that plausibly feed star formation. In the observations, many SB and oval galaxies show central concentrations of gas and star formation. Star formation rates imply plausible pseudobulge growth times of a few billion years. If secular processes built dense central components that masquerade as bulges, can we distinguish them from merger-built bulges? Observations show that pseudobulges retain a memory of their disky origin. They have one or more characteristics of disks: (1) flatter shapes than those of classical bulges, (2) large ratios of ordered to random velocities indicative of disk dynamics, (3) small velocity dispersions, (4) spiral structure or nuclear bars in the bulge part of the light profile, (5) nearly exponential brightness profiles, and (6) starbursts. These structures occur preferentially in barred and oval galaxies in which secular evolution should be rapid. So the cleanest examples of pseudobulges are recognizable. Thus a large variety of observational and theoretical results contribute to a new picture of galaxy evolution that complements hierarchical clustering and merging.Comment: 92 pages, 21 figures in 30 Postscript files; to appear in Annual Review of Astronomy and Astrophysics, Vol. 42, 2004, in press; for a version with full resolution figures, see http://chandra.as.utexas.edu/~kormendy/ar3ss.htm