56 research outputs found
Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies
The Wide Field Spectrograph (WiFeS)
This paper describes the Wide Field Spectrograph (WiFeS) under construction
at the Research School of Astronomy and Astrophysics (RSAA) of the Australian
National University (ANU) for the ANU 2.3m telescope at the Siding Spring
Observatory. WiFeS is a powerful integral field, double-beam, concentric,
image-slicing spectrograph designed to deliver excellent thoughput, wavelength
stability, spectrophotometric performance and superb image quality along with
wide spectral coverage throughout the 320-950 nm wavelength region. It provides
a 25x38 arcsec. field with 0.5 arcsec. sampling along each of twenty five 38X1
arcsec slitlets. The output format is optimized to match the 4096x4096 pixel
CCD detectors in each of two cameras individually optimized for the blue and
the red ends of the spectrum, respectively. A process of "interleaved
nod-and-shuffle" will be applied to permit quantum noise-limited sky
subtraction. Using VPH gratings, spectral resolutions of 3000 and 7000 are
provided. The full spectral range is covered in a single exposure at R=3000,
and in two exposures in the R=7000 mode. The use of transmissive coated optics,
VPH gratings and optimized mirror coatings ensures a throughput (including
telescope atmosphere and detector) > 30% over a wide spectral range. The
concentric image-slicer design ensures an excellent and uniform image quality
across the full field. To maximize scientific return, the whole instrument is
configured for remote observing, pipeline data reduction, and the accumulation
of calibration image libraries.Comment: Accepted for publication in Astrophysics & Space Science, 16 pages,
14 figure
Optical Spectra of SNR Candidates in NGC 300
We present moderate-resolution (<5A) long-slit optical spectra of 51 nebular
objects in the nearby Sculptor Group galaxy NGC 300 obtained with the 2.3 meter
Advanced Technology Telescope at Siding Spring Observatory, Australia. Adopting
the criterion of [SII]/Ha>=0.4 to confirm supernova remnants (SNRs) from
optical spectra, we find that of 28 objects previously proposed as SNRs from
optical observations, 22 meet this criterion with six showing [SII]/Ha of less
than 0.4. Of 27 objects suggested as SNRs from radio data, four are associated
with the 28 previously proposed SNRs. Of these four, three (included in the 22
above) meet the criterion. In all, 22 of the 51 nebular objects meet the
[SII]/Ha criterion as SNRs while the nature of the remaining 29 objects remains
undetermined by these observations.Comment: Accepted for publication in Astrophysics & Space Scienc
A Binary Lensing Event Toward the LMC: Observations and Dark Matter Implications
The MACHO collaboration has recently analyzed 2.1 years of photometric data
for about 8.5 million stars in the Large Magellanic Cloud (LMC). This analysis
has revealed 8 candidate microlensing events and a total microlensing optical
depth of . This significantly
exceeds the number of events (1.1) and the microlensing optical depth predicted
from known stellar populations: , but it is
consistent with models in which about half of the standard dark halo mass is
composed of Machos of mass \sim 0.5 \msun. One of these 8 events appears to
be a binary lensing event with a caustic crossing that is partially resolved
which allows us to estimate the distance to the lenses. If the source star is
not a short period binary star, then we show that the lens system is very
likely to reside in the LMC. However, if we assume that the optical depth for
LMC-LMC lensing is large enough to account for our entire lensing signal, then
the binary event does not appear to be consistent with lensing of a single LMC
source star by a binary residing in the LMC. Thus, while the binary lens may
indeed reside in the LMC, there is no indication that most of the lenses reside
in the LMC.Comment: 5 pages, 3 postscript figures included; To appear in the Proceedings
of the Dark Matter '96 Conference held in Santa Monica, CA, Feb., 199
The MACHO Project 2nd Year LMC Microlensing Results and Dark Matter Implications
The MACHO Project is searching for galactic dark matter in the form of
massive compact halo objects (Machos). Millions of stars in the Large
Magellanic Cloud (LMC), Small Magellanic Cloud (SMC), and Galactic bulge are
photometrically monitored in an attempt to detect rare gravitational
microlensing events caused by otherwise invisible Machos. Analysis of two years
of photometry on 8.5 million stars in the LMC reveals 8 candidate microlensing
events, far more than the event expected from lensing by low-mass stars
in known galactic populations. From these eight events we estimate the optical
depth towards the LMC from events with 2 < \that < 200 days to be
\tau_2^{200} \approx 2.9 ^{+1.4}_{-0.9} \ten{-7}. This exceeds the optical
depth of 0.5\ten{-7} expected from known stars and is to be compared with an
optical depth of 4.7\ten{-7} predicted for a ``standard'' halo composed
entirely of Machos. The total mass in this lensing population is \approx
2^{+1.2}_{-0.7} \ten{11} \msun (within 50 kpc from the Galactic center). Event
timescales yield a most probable Macho mass of 0.5^{+0.3}_{-0.2}\msun,
although this value is quite model dependent.Comment: 10 pages, 6 epsf figures and style file included, 451k, also at
http://wwwmacho.mcmaster.ca/Pubs/Pubs.html; To appear in the Proceedings of
"Sources and Detection of Dark Matter in the Universe", Santa Monica, CA,
Feb., 199
Analytical modelling and MDOF response considerations for semi-active tuned mass damper building systems subjected to earthquake excitation
plenary keynote paperPassive and Semi-Active Tuned Mass Damper (PTMD and SATMD) building
systems can reduce structural response due to earthquake excitation. The structureâs
upper portion can be used either as a passive TMD, or as a semi-active resetable
device in a SATMD system. The seismic performance of multi-story passive and
semi-active tuned mass damper (PTMD and SATMD) building systems are
investigated for 12-story moment resisting frames modeled as â10+2â stories and
â8+4â stories. Segmented upper stories are isolated to act as the tuned mass. Passive
viscous damper or semi-active resetable devices are evaluated using an energy
dissipation strategy based on an optimal TMD design stiffness and damping value.
The semi-active approach uses feedback control to alter or manipulate the reaction
forces, effectively re-tuning the system depending on the structural response.
Statistical performance metrics are presented for 30 earthquake records from the 3
suites of the SAC project. Time history analyses are used to compute response
reduction factors across a wide range of seismic hazard intensities. Results show
that SATMD systems can effectively manage seismic response for multi-degree-of
freedom (MDOF) systems across a broader range of ground motions in comparison
to passive solutions. Specific results include the identification of differences in the
mechanisms by which SATMD and PTMD systems remove energy, based on the
differences in the devices used. Less variability is also seen for the SATMD
systems, indicating an increased robustness
Person-centered/experiential psychotherapy for anxiety difficulties : theory, research and practice
Anxiety difficulties are an increasingly important focus for person-centered/experiential (PCE) psychotherapies. I begin by reviewing person-centered, focusing-oriented, and emotion-focused therapy (EFT) theories of anxiety. Next, I summarize a meta-analysis of 19 outcome studies of PCE therapies for adults with anxiety, most commonly supportive or person-centered therapies (PCT) carried out by cognitive behavior therapy (CBT) researchers. The results indicate large pre-post change but a clear inferiority to CBT. I then summarize promising early results from an ongoing study of PCT and EFT for social anxiety, which show large amounts of pre-post change for both forms of PCE therapy but substantially more change for clients in the EFT condition. I conclude with a discussion of the implications for PCE therapy practice, including the value of process differentiation and the possibility of developing more effective PCE approaches for anxiety
- âŠ