213 research outputs found
Infrared picosecond transient hole-burning studies of the effects of hydrogen bonds on the vibrational line shape
With infrared transient hole-burning spectroscopy we have investigated the influence of OD ... X hydrogen bonds on the vibrational line shape of O-D stretch vibrations in acid zeolites. The effect of hydrogen bonding on the line shape depends critically on the type of hydrogen bond. For hydrogen bonding in a rigid structure, the hydrogen bond determines the inhomogeneous linewidth, but the homogeneous linewidth is determined by coupling to a similar to 200 cm(-1) lattice mode as concluded from the temperature dependence of the dephasing rate. When the hydrogen bond is formed with an adsorbing molecule, the coupling between the high-frequency O-D stretch vibration and the low-frequency OD ... X hydrogen-bond stretching mode does determine the homogeneous linewidth. The difference between the two systems can be explained by the different hydrogen-bond potentials. Variation of the adsorbate provides a means of obtaining conclusive information on the coupling mechanism between the high-frequency O-D stretching mode and the low-frequency OD ... X hydrogen-bond stretching mode. (C) 1996 American Institute of Physic
Mesoscopic proximity effect in double barrier Superconductor/Normal Metal junctions
We report transport measurements down to T=60mK of SININ and SNIN structures
in the diffusive limit. We fabricated Al-AlOx/Cu/AlOx/Cu (SININ) and
Al/Cu/AlOx/Cu (SNIN) vertical junctions. For the first time, a zero bias
anomaly was observed in a metallic SININ structure. We attribute this peak of
conductance to coherent multi-reflections of electrons between the two tunnel
barriers. This conductance maximum is quantitatively fitted by the relevant
theory of mesoscopic SININ structures. When the barrier at the SN interface is
removed (SNIN structure), we observe a peak of conductance at finite voltage
accompagnied by an excess of sub-gap conductance.Comment: 4 pages, 4 figures, editorially approved for publication in Phys.
Rev. B Rapid Com
Neurofibromatosis type 2 protein co-localizes with elements of the cytoskeleton
The product of the neurofibromatosis type 2 (NF2) tumor suppressor gene is a 595-amino-acid protein bearing resemblance to a family of band-4.1-related proteins. These proteins, including ezrin, radixin, and moesin, probably function as molecular linking proteins, connecting the cytoskeleton to the cell membrane. On the grounds of the homology to the ezrin, radixin, and moesin proteins and on the basis of its predicted secondary structure, the NF2 protein is also thought to act as a cytoskeleton-cell membrane linking protein. Using monoclonal antibodies to amino- and carboxyl-terminal synthetic NF2 peptides we demonstrate the co-localization of the NF2 protein with elements of the cytoskeleton in a COS cell model system and in cultured human cells. Furthermore, the presence of the NF2 protein in tissue sections is shown. The monoclonal antibodies specifically stain smooth muscle cells and the stratum granulosum of the human epidermis. In cultured smooth muscle cells the NF2 protein co-localizes with actin stress fibers. Immunoelectron microscopy demonstrates the presence of the NF2 protein associated with keratohyalin granules and to a lesser extent with intermediate filaments in the human epidermis. We conclude that the NF2 protein is indeed associated with multiple elements of the cytoskeleton.</p
Neurofibromatosis type 2 protein co-localizes with elements of the cytoskeleton
The product of the neurofibromatosis type 2 (NF2) tumor suppressor gene is a 595-amino-acid protein bearing resemblance to a family of band-4.1-related proteins. These proteins, including ezrin, radixin, and moesin, probably function as molecular linking proteins, connecting the cytoskeleton to the cell membrane. On the grounds of the homology to the ezrin, radixin, and moesin proteins and on the basis of its predicted secondary structure, the NF2 protein is also thought to act as a cytoskeleton-cell membrane linking protein. Using monoclonal antibodies to amino- and carboxyl-terminal synthetic NF2 peptides we demonstrate the co-localization of the NF2 protein with elements of the cytoskeleton in a COS cell model system and in cultured human cells. Furthermore, the presence of the NF2 protein in tissue sections is shown. The monoclonal antibodies specifically stain smooth muscle cells and the stratum granulosum of the human epidermis. In cultured smooth muscle cells the NF2 protein co-localizes with actin stress fibers. Immunoelectron microscopy demonstrates the presence of the NF2 protein associated with keratohyalin granules and to a lesser extent with intermediate filaments in the human epidermis. We conclude that the NF2 protein is indeed associated with multiple elements of the cytoskeleton.</p
High Early Fluid Input After Aneurysmal Subarachnoid Hemorrhage: Combined Report of Association With Delayed Cerebral Ischemia and Feasibility of Cardiac Output–Guided Fluid Restriction
Background: Guidelines on the management of aneurysmal subarachnoid hemorrhage (aSAH) recommend euvolemia, whereas hypervolemia may cause harm. We investigated whether high early fluid input is associated with delayed cerebral ischemia (DCI), and if fluid input can be safely decreased using transpulmonary thermodilution (TPT). Methods: We retrospectively included aSAH patients treated at an academic intensive care unit (2007-2011; cohort 1) or managed with TPT (2011-2013; cohort 2). Local guidelines recommended fluid input of 3 L daily. More fluids were administered when daily fluid balance fell below +500 mL. In cohort 2, fluid input in high-risk patients was guided by cardiac output measured by TPT per a strict protocol. Associations of fluid input and balance with DCI were analyzed with multivariable logistic regression (cohort 1), and changes in hemodynamic indices after institution of TPT assessed with linear mixed models (cohort 2). Results: Cumulative fluid input 0 to 72 hours after admission was associated with DCI in cohort 1 (n=223; odds ratio [OR] 1.19/L; 95% confidence interval 1.07-1.32), whereas cumulative fluid balance was not. In cohort 2 (23 patients), using TPT fluid input could be decreased from 6.0 ± 1.0 L before to 3.4 ± 0.3 L; P =.012), while preload parameters and consciousness remained stable. Conclusion: High early fluid input was associated with DCI. Invasive hemodynamic monitoring was feasible to reduce fluid input while maintaining preload. These results indicate that fluid loading beyond a normal preload occurs, may increase DCI risk, and can be minimized with TPT
Special relativity constraints on the effective constituent theory of hybrids
We consider a simplified constituent model for relativistic
strong-interaction decays of hybrid mesons. The model is constructed using
rules of renormalization group procedure for effective particles in light-front
quantum field theory, which enables us to introduce low-energy phenomenological
parameters. Boost covariance is kinematical and special relativity constraints
are reduced to the requirements of rotational symmetry. For a hybrid meson
decaying into two mesons through dissociation of a constituent gluon into a
quark-anti-quark pair, the simplified constituent model leads to a rotationally
symmetric decay amplitude if the hybrid meson state is made of a constituent
gluon and a quark-anti-quark pair of size several times smaller than the
distance between the gluon and the pair, as if the pair originated from one
gluon in a gluonium state in the same effective theory.Comment: 11 pages, 5 figure
Independence of , Poincare Invariance and the Non-Conservation of Helicity
A relativistic constituent quark model is found to reproduce the recent data
regarding the ratio of proton form factors, . We show that
imposing Poincare invariance leads to substantial violation of the helicity
conservation rule, as well as an analytic result that the ratio
for intermediate values of .Comment: 13 pages, 7 figures, to be submitted to Phys. Rev. C typos corrected,
references added, 1 new figure to show very high Q^2 behavio
Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails
Pathogenesis and treatment of chronic pulmonary disease
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