Protein-Coated Magnetic Nanoparticles: Creation and Investigation

A novel universal approach to cross-linking of protein macromolecules on the surface of magnetite na-noparticles has been developed. The approach is based on protein liability to free radical modification, leading to the formation of intermolecular covalent cross links. Free radicals are locally generated on the surface of nanoparticles. Using a set of physicochemical methods, it has been proven that stable coatings composed of protein macromolecules are formed around individual nanoparticles. The proteins fixed on nanoparticles do not lose their activity as a result of adsorption and free radical modification. Fluorescent probe approach for evaluation of the native functional properties of serum albumin as a part of coating is suggested. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3537

The Becoming and Development of the Scientific School of Physiology of Kidneys and Water-Salt Metabolism in Novosibirsk

The article considers analysis of stages of becoming and development of scientific school of physiology of kidneys and water-salt metabolism in at the chair of normal physiology of the Novosibirsk State Medical Institute (University) being one of branches of prominent physiological school of I. P. Pavlov-L. A. Orbeli-A. G. Ginetsinsky and his disciples. An original periodization of its history (precondition, becoming, development and concluding periods) is proposed. The fundamental role of professor A.G. Ginetsinsky in becoming of the given physiological school and its further development under the guidance of professor Ya.D. Finkinshtein are established. The key directions of activities of this scientific school such as links of reflex mechanisms of osmoregulation; the ontogenic features of osmoregulatory mechanisms, role of hypothalamic-pituitary system hormones in maintenance of water-electrolyte homeostasis, osmoregulatory reflexes at various pathophysiological processes, regulation of micro-circulatory processes of formation of cerebro-spinal liquid, development of conceptions of reflex regulation of ionic homeostasis are established and analyzed. The study demonstrated that the given physiological school fully conforms to criteria of scientific school (availability of leader, intergenerational continuity, unity of problematics, duration of existence in time and space, recognition of input into science by disciplinary scientific community)

Application of low-angle laser scattering to the quality control of pharmaceutical powders and suspensions. 2. Barium sulfate

Low-angle light scattering was used for dispersion analysis of samples of barium sulfate substance for radiography obtained from various manufacturers. Particles with sizes of greater than 10 μm were detected, which is not in compliance with normative specifications. Results obtained using barium sulfate substance as an example allow the low-angle laser light scattering method to be recommended for the rapid control of particle size in the disperse phases of medicinal suspensions and powders. © 2009 Springer Science+Business Media, Inc

Application of low-angle laser scattering to the quality control of pharmaceutical powders and suspensions. 2. Barium sulfate

Low-angle light scattering was used for dispersion analysis of samples of barium sulfate substance for radiography obtained from various manufacturers. Particles with sizes of greater than 10 μm were detected, which is not in compliance with normative specifications. Results obtained using barium sulfate substance as an example allow the low-angle laser light scattering method to be recommended for the rapid control of particle size in the disperse phases of medicinal suspensions and powders. © 2009 Springer Science+Business Media, Inc