57 research outputs found
Conformally coupled supermultiplets in four and five dimensions
We obtain by superfield methods the exceptional representations of the
OSp(2N/4,R) and SU(2,2/1) superalgebras which extend to supersingletons of
SU(2,2/2N) and F(4), respectively. These representations describe
superconformally coupled multiplets and appear in three- and four-dimensional
superconformal field theories which are holographic descriptions of certain
anti-de Sitter supergravities
Quantitative trait loci for bone traits segregating independently of those for growth in an F-2 broiler X layer cross
An F broiler-layer cross was phenotyped for 18 skeletal traits at 6, 7 and 9 weeks of age and genotyped with 120 microsatellite markers. Interval mapping identified 61 suggestive and significant QTL on 16 of the 25 linkage groups for 16 traits. Thirty-six additional QTL were identified when the assumption that QTL were fixed in the grandparent lines was relaxed. QTL with large effects on the lengths of the tarsometatarsus, tibia and femur, and the weights of the tibia and femur were identified on GGA4 between 217 and 249 cM. Six QTL for skeletal traits were identified that did not co-locate with genome wide significant QTL for body weight and two body weight QTL did not coincide with skeletal trait QTL. Significant evidence of imprinting was found in ten of the QTL and QTL x sex interactions were identified for 22 traits. Six alleles from the broiler line for weight- and size-related skeletal QTL were positive. Negative alleles for bone quality traits such as tibial dyschondroplasia, leg bowing and tibia twisting generally originated from the layer line suggesting that the allele inherited from the broiler is more protective than the allele originating from the layer
Lo-Fi Matchmaking: A Study of Social Pairing for Backpackers
There is a new world emerging around mobile social networks and the technologies used to facilitate and mediate them. It is technically feasible for mobile social software such as pairing or matchmaking systems to introduce people to others and assist information exchange. However, little is known about the social structure of many mobile communities or why they would want pairing systems. When these systems are built, it is not clear what the social response by those communities will be or what the systems will be like to use in practice. While engaged in other work determining requirements for a mobile travel assistant we saw a potentially useful application for a pairing system to facilitate the exchange of travel information between backpackers. To explore this area, we designed two studies involving usage of a low-fidelity role prototype of a social pairing system for backpackers. Graphs of the resulting social pairings showed backpackers who were hubs in the network of travel information. It also demonstrated the effect of travel direction on information utility. Backpackers rated the utility of different pairing types, and provided feedback on the social implications of being paired based on travel histories. Practical usage of the social network pairing activity and the implications of broader societal usage are discussed
Topology and Flux of T-Dual Manifolds with Circle Actions
We present an explicit formula for the topology and H-flux of the T-dual of a
general type II compactification, significantly generalizing earlier results.
Our results apply to T-dualities with respect to any circle action on
spacetime. As before, T-duality exchanges type IIA and type IIB string
theories. A new consequence is that the T-dual spacetime is a singular space
when the fixed point set is non-empty; the singularities correspond to
Kaluza-Klein monopoles. We propose that the Ramond-Ramond charges of type II
string theories on the singular dual are classified by twisted equivariant
cohomology groups. We also include the K-theory approach.Comment: 9 pages, 1 figure, version to appear in CM
Quantum Creation of an Open Inflationary Universe
We discuss a dramatic difference between the description of the quantum
creation of an open universe using the Hartle-Hawking wave function and the
tunneling wave function. Recently Hawking and Turok have found that the
Hartle-Hawking wave function leads to a universe with Omega = 0.01, which is
much smaller that the observed value of Omega > 0.3. Galaxies in such a
universe would be about light years away from each other, so the
universe would be practically structureless. We will argue that the
Hartle-Hawking wave function does not describe the probability of the universe
creation. If one uses the tunneling wave function for the description of
creation of the universe, then in most inflationary models the universe should
have Omega = 1, which agrees with the standard expectation that inflation makes
the universe flat. The same result can be obtained in the theory of a
self-reproducing inflationary universe, independently of the issue of initial
conditions. However, there exist two classes of models where Omega may take any
value, from Omega > 1 to Omega << 1.Comment: 23 pages, 4 figures. New materials are added. In particular, we show
that boundary terms do not help to solve the problem of unacceptably small
Omega in the new model proposed by Hawking and Turok in hep-th/9803156. A
possibility to solve the cosmological constant problem in this model using
the tunneling wave function is discusse
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
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