7 research outputs found

    L'elisir del furto secondo il dharma

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    Il personaggio principale, un brahmano ben versato nella scienza tradizionale, dimostra con grande spregiudicatezza e arguzia come il il furto, lungi da essere immorale o biasimevole, sia invece una disciplina encomiabile e virtuosa, purch\ue9 praticato secondo i criteri della propria arte

    Premessa

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    Premessa generale al volume

    L'esaltazione della Dea: un breve approccio al Devī-Māhātmya

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    Introduzione al ms. Tessitori e al Devī-Māhātmya

    Heparin protection against Fe2+-and Cu2+-mediated oxidation of liposomes.

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    Heparin (HE) exhibited a protective effect on liposome peroxidation induced by Fe2+ and Cu2+, decreasing the formation of both conjugated dienes and thiobarbituric acid reactive substances (TBARS) in a dose-dependent manner. The antioxidant activity was more relevant in the oxidizing system employing Fe2+ and H2O2 and generating the highly reactive OH radical. The analysis of liposome size distribution by quasielastic laser light scattering showed that: (1) the native structure of the particles was completely lost after exposure to Fenton reagent; (2) the presence of HE in the reaction mixture completely prevented the peroxidative damage on liposomes. Thus, HE acts as an antioxidant factor on membrane lipid bilayer. This suggests that HE, released from mast-cell granules during inflammatory processes, might locally protect the cell membrane from the oxidative injuries

    The effect of heparin on Cu++-mediated oxidation of human low-density lipoproteins.

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    The effect of heparin (HE) on the susceptibility of human low-density lipoprotein (LDL) to Cu(2+)-induced oxidation was investigated by monitoring conjugated diene formation. HE did not modify the maximum formation of conjugated diene, but increased markedly the lag phase. The plot of change in oxidation rate vs. time showed that the absolute value of Vmax was dependent on Cu2+ concentration and that HE increased the time necessary to reach Vmax. The value of constant K (the Cu2+ concentration producing a tlag of twice the minimum value) increased in the presence of HE, whereas the value of tmin (the time theoretically required for LDL oxidation at an infinite Cu2+ concentration) was not substantially affected. These results indicate that HE might play a protective antioxidant effect on LDL, probably affecting both the structural properties of the particle and the amount of Cu2+ available for the oxidation
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