Complex direct comb spectroscopy with a virtually imaged phased array

LetterAbstract not availableSarah K. Scholten, James D. Anstie, Nicolas Bourbeau Hébert, Richard T. White, Jérôme Genest, and Andre N. Luite

Applicability and reproducibility of acute myeloid leukaemia stem cell assessment in a multi-centre setting

Leukaemic stem cells (LSC) have been experimentally defined as the leukaemia-propagating population and are thought to be the cellular reservoir of relapse in acute myeloid leukaemia (AML). Therefore, LSC measurements are warranted to facilitate accurate risk stratification. Previously, we published the composition of a one-tube flow cytometric assay, characterised by the presence of 13 important membrane markers for LSC detection

Professionals’ opinion on follow-up in breast cancer patients; perceived purpose and influence of patients’ risk factors

International audienceTo provide insight into professionals' opinions on breast cancer follow-up to facilitate implementation of new follow-up strategies. The study focuses on current practice, purpose and perceived effects, and preferred frequency and duration of follow-up

Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma.

Contains fulltext : 50632.pdf (publisher's version ) (Closed access)Cell adhesion molecules, such as epithelial cadherin (E-cadherin), might be involved in the processes of tumor invasion and differentiation. The aim of this study was to investigate the expression of E-cadherin, alpha-catenin, and beta-catenin in endometrial carcinoma and to determine the prognostic value of these factors. We have investigated the expression of E-cadherin, alpha-catenin, and beta-catenin by immunohistochemistry in 225 endometrial carcinomas. The correlation between the E-cadherin and the catenins and their correlation with several histologic and clinical parameters were analyzed. Negative E-cadherin, alpha-catenin, and beta-catenin expression was observed in 44%, 47%, and 33% of endometrial carcinomas, respectively, and was correlated with histologic FIGO grade 3 (P < 0.001). Negative E-cadherin expression was more often observed in nonendometrioid endometrial carcinomas (NEECs) than in endometrioid carcinomas (75% versus 43%; P= 0.04). Combined positive E-cadherin, alpha-catenin, and beta-catenin expression was an independent positive prognostic factor for survival in patients with grade 1-2 carcinomas (P= 0.02). Negative E-cadherin expression was found to be associated with histologic grade 3 and with NEEC. Combined positive E-cadherin, alpha-catenin, and beta-catenin expression was a significant prognostic factor

Ultrahigh-resolution direct-frequency-comb spectrometer

At low pressures, molecular spectra typically exhibit a large number of very narrow absorption features spread across a relatively wide spectral bandwidth. In order to obtain an accurate estimate of the line shapes, widths, and depths of these absorption features it is a requirement that one performs spectroscopy that is both densely spaced and high resolution across the entire spectral range. Here we demonstrate an approach that delivers on this need: it makes use of an optical frequency comb as the light source along with an optical filter cavity and a dispersive spectrometer to acquire high-resolution spectra with dense spectral sampling. The technique has the potential to acquire spectra with a resolution limit imposed solely by the frequency stability of the comb. As a proof of concept we measure the absorption spectrum of acetylene with a 7.86-MHz spectral spacing over 3.4-THz (25 nm) spectral range. This represents more than 430 000 individual spectral measurements, which are each individually free from the instrumentation broadening that limits conventional spectrometers. Using this spectrum, we extract the thermodynamic properties (temperature, pressure, and molecular density) of the gas sample with high accuracy and precision while simultaneously performing gas compositional analysis.Faisal Karim, Sarah K. Scholten, Christopher Perrella and Andre N. Luite

Optimal Registration Method of MRI and CT for Delineation in Radiation Therapy Planning of Breast Cancer Patients Treated With Breast Conserving Therapy

Biological, physical and clinical aspects of cancer treatment with ionising radiatio

Preradiotherapy Calcium Scores of the Coronary Arteries in a Cohort of Women With Early-Stage Breast Cancer: A Comparison With a Cohort of Healthy Women

Clinical Oncolog

Preradiotherapy Calcium Scores of the Coronary Arteries in a Cohort of Women With Early-Stage Breast Cancer: A Comparison With a Cohort of Healthy Women

Clinical Oncolog

Pre Radiotherapy Calcium Scores of Coronary Arteries in Women with Breast Cancer: a Comparative Study

Clinical Oncolog