Gravitational fields with a non Abelian bidimensional Lie algebra of symmetries

Vacuum gravitational fields invariant for a bidimensional non Abelian Lie algebra of Killing fields, are explicitly described. They are parameterized either by solutions of a transcendental equation (the tortoise equation) or by solutions of a linear second order differential equation on the plane. Gravitational fields determined via the tortoise equation, are invariant for a 3-dimensional Lie algebra of Killing fields with bidimensional leaves. Global gravitational fields out of local ones are also constructed.Comment: 8 pagese, latex, no figure

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting

Vacuum Einstein metrics with bidimensional Killing leaves, I-Local aspects

The solutions of vacuum Einstein's field equations, for the class of Riemannian metrics admitting a non-Abelian bidimensional Lie algebra of Killing fields, are explicitly described. They are parametrized either by solutions of a transcendental equation (the tortoise equation), or by solutions of a linear second order differential equation in two independent variables. Metrics, corresponding to solutions of the tortoise equation, are characterized as those that admit a 3-dimensional Lie algebra of Killing fields with bidimensional leaves