Bimodal granulocyte transit time through the human lung demonstrated by deconvolution analysis

AbstractThe lungs are an important site of granulocyte pooling. The aim of the study is to quantify pulmonary vascular granulocyte transit time using deconvolution analysis, as has previously been performed to measure pulmonary red cell transit time. Granulocyte and red cell studies were performed in separate groups of patients. Both cell types were labelled with Tc-99m, which for granulocyte labelling was complexed with hexamethylpropyleneamine oxime (HMPAO). The red cell impulse response function (IRF) was monoexponential with a median transit time of 4·3 s. The granulocyte IRF was biexponential in 19 of 22 subjects, 18 of whom had systemic inflammation (inflammatory bowel disease, systemic vasculitis or graft-vs-host disease) and four were controls without inflammatory disease. The median transit time of the fast component ranged from 20 to 25 s and of the slow component 120–138 s in the four patient groups. The fraction of cells undergoing slow transit correlated significantly with (a) mean granulocyte transit time and (b) the fraction showing shape change in vitro. We conclude that granulocyte transit time through the pulmonary circulation is bimodal and that shape-changed (activated) cells transit more slowly that non-activated cells. The size of the fraction undergoing slow transit is closely related to mean granulocyte transit time and is an important determinant of the size of the pulmonary vascular granulocyte pool

Unsolvability of the Halting Problem in Quantum Dynamics

It is shown that the halting problem cannot be solved consistently in both the Schrodinger and Heisenberg pictures of quantum dynamics. The existence of the halting machine, which is assumed from quantum theory, leads into a contradiction when we consider the case when the observer's reference frame is the system that is to be evolved in both pictures. We then show that in order to include the evolution of observer's reference frame in a physically sensible way, the Heisenberg picture with time going backwards yields a correct description.Comment: 4 pages, 3 figure

M5-brane geometries, T-duality and fluxes

We describe a duality relation between configurations of M5-branes in M-theory and type IIB theory on Taub-NUT geometries with NSNS and RR 3-form field strength fluxes. The flux parameters are controlled by the angles between the M5-brane and the (T)duality directions. For one M5-brane, the duality leads to a family of supersymmetric flux configurations which interpolates between imaginary self-dual fluxes and fluxes similar to the Polchinski-Strassler kind. For multiple M5-branes, the IIB configurations are related to fluxes for twisted sector fields in orbifolds. The dual M5-brane picture also provides a geometric interpretation for several properties of flux configurations (like the supersymmetry conditions, their contribution to tadpoles, etc), and for many non-trivial effects in the IIB side. Among the latter, the dielectric effect for probe D3-branes is dual to the recombination of probe M5-branes with background ones; also, a picture of a decay channel for non-supersymmetric fluxes is suggested.Comment: 30 pages, 3 figure

Attitudes towards potential new tobacco control regulations among U.S. adults

Favorable attitudes towards tobacco control policies can facilitate their implementation and success. We examined attitudes toward four potential U.S. Federal tobacco regulations (banning menthol from cigarettes, reducing nicotine levels in cigarettes, banning candy and fruit flavored electronic cigarettes, and banning candy and fruit flavored little cigars and cigarillos) and associations with individual and state variables. A nationally representative phone survey of 4337 adults assessed attitudes toward potential policies. Weighted logistic regression was used to assess relationships between attitudes and demographic factors, smoking behavior, beliefs about the government (knowledge, trust, and credibility), exposure to tobacco control campaigns, and state variables from the US Centers for Disease Control and Prevention (CDC) State Tobacco Activities Tracking and Evaluation (STATE) System. Most respondents supported three out of four policies. Respondents that were female, non-white, Latino, living below the poverty line, had less than high school education, were of older age, did not smoke, had higher trust in government, and were exposed to national tobacco control campaigns had higher odds of expressing favorable attitudes toward potential new tobacco regulations than did their counterparts. No state-level effects were found. While differences in attitudes were observed by individual demographic characteristics, behaviors, and beliefs, a majority of participants supported most of the potential new tobacco regulations surveyed

Should the legal age for tobacco be raised? Results from a national sample of adolescents

Raising the minimum age of legal access to tobacco products may reduce smoking initiation and save lives. In a national telephone survey (2014-2015), US adolescents aged 13 to 17 years (N = 1,125; response rate, 66%) were asked about raising the age of legal access to tobacco products and randomized to hear one of 3 ages (19, 20, or 21 y). Most adolescents, across all US regions, favored raising the minimum age of legal access to 19 (75.7%), 20 (80.6%), or 21 (76.4%). These supportive attitudes may be useful to tobacco prevention and control practitioners who seek to reduce tobacco use among adolescents

Reissner-Nordstrom-de Sitter black hole, planar coordinates and dS/CFT

We discuss the Reissner-Nordstrom-de Sitter black holes in the context of dS/CFT correspondence by using static and planar coordinates. The boundary stress tensor and the mass of the solutions are computed. Also, we investigate how the RG flow is changed for different foliations. The Kastor-Traschen multi-black hole solution is considered as well as AdS counterparts of these configurations. In particular, we find that in planar coordinates the black holes appear like punctures in the dual boundary theory.Comment: 30 pages, 3 eps figures, JHEP style v2: new references added, misprints correcte

Higher Dimensional Recombination of Intersecting D-branes

We study recombinations of D-brane systems intersecting at more than one angle using super Yang-Mills theory. We find the condensation of an off-diagonal tachyon mode relates to the recombination, as was clarified for branes at one angle in hep-th/0303204. For branes at two angles, after the tachyon mode between two D2-branes condensed, D2-brane charge is distributed in the bulk near the intersection point. We also find that, when two intersection angles are equal, the off-diagonal lowest mode is massless, and a new stable non-abelian configuration, which is supersymmetric up to a quadratic order in the fluctuations, is obtained by the deformation by this mode.Comment: 18 pages, 2 figures, JHEP style. v3:references added, minor corrections, English improve

Entropy in the RST Model

The RST Model is given boundary term and Z-field so that it is well-posed and local. The Euclidean method is described for general theory and used to calculate the RST intrinsic entropy. The evolution of this entropy for the shockwave solutions is found and obeys a second law.Comment: 10 pages, minor revisions, published version in Late