79 research outputs found
Effects of intraarticular treatment with stanozolol on synovial membrane and cartilage in an ovine model of osteoarthritis
Aim of the study was to verify the clinical and morphological effects of intra-articular stanozolol or placebo
treatment, lasting 3 and 9 months, in sheep in which a femoro-tibial osteo-arthritis (OA) were surgically
induced (medial bilateral meniscectomy).
Twenty healthy sheep divided into four groups and two control animals group, after surgical medial
bilateral meniscectomy, were weekly injected in femoral-tibial joint (FTJ) with stanozolol or placebo.
Lameness evaluation was performed and synovial fluid was collected from all sheep at each treatment
time. Necropsies were performed after 3 or 9 month as described in experimental design. Gross pathologies
were described and specimen tissues collected from femoro-tibial articular joints were processed
for routine histological examination.
The gross anatomy of the FTJ was well-preserved in stanozolol-treated sheep; this also applied to the
histological features of articular cartilage. Joint aseptic inflammation and fibrosis were observed in placebo-
treated sheep, associated with a different degree of severity of condylar and tibial plate cartilage
degeneration.
Stanozolol intra-articular treatment reduces osteophytes formation and subchondral bone reaction and
promotes articular cartilage regeneration
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