776 research outputs found
Epidemiology of traffic accidents
The epidemiology of traffic accidents is studied. Various factors include the nature of fatal injuries, the racial, sex and age distribution, the scene of accident, the weather and the time, the different categories of commuters and the trip purpose, the types of vehicles and motorways involved. The establishment of a traffic accident assessment team is recommended.S. Afr. Med. J., 48, 599 (1974)
Data-driven discovery of cardiolipin-selective small molecules by computational active learning
The role of caretakers in disease dynamics
One of the key challenges in modeling the dynamics of contagion phenomena is
to understand how the structure of social interactions shapes the time course
of a disease. Complex network theory has provided significant advances in this
context. However, awareness of an epidemic in a population typically yields
behavioral changes that correspond to changes in the network structure on which
the disease evolves. This feedback mechanism has not been investigated in
depth. For example, one would intuitively expect susceptible individuals to
avoid other infecteds. However, doctors treating patients or parents tending
sick children may also increase the amount of contact made with an infecteds,
in an effort to speed up recovery but also exposing themselves to higher risks
of infection. We study the role of these caretaker links in an adaptive network
models where individuals react to a disease by increasing or decreasing the
amount of contact they make with infected individuals. We find that pure
avoidance, with only few caretaker links, is the best strategy for curtailing
an SIS disease in networks that possess a large topological variability. In
more homogeneous networks, disease prevalence is decreased for low
concentrations of caretakers whereas a high prevalence emerges if caretaker
concentration passes a well defined critical value.Comment: 8 pages, 9 figure
The first long-read nuclear genome assembly of Oryza australiensis, a wild rice from northern Australia
Oryza australiensis is a wild rice native to monsoonal northern Australia. The International Oryza Map Alignment Project emphasises its significance as the sole representative of the EE genome clade. Assembly of the O. australiensis genome has previously been challenging due to its high Long Terminal Repeat (LTR) retrotransposon (RT) content. Oxford Nanopore long reads were combined with Illumina short reads to generate a high-quality ~ 858 Mbp genome assembly within 850 contigs with 46× long read coverage. Reference-guided scaffolding increased genome contiguity, placing 88.2% of contigs into 12 pseudomolecules. After alignment to the Oryza sativa cv. Nipponbare genome, we observed several structural variations. PacBio Iso-Seq data were generated for five distinct tissues to improve the functional annotation of 34,587 protein-coding genes and 42,329 transcripts. We also report SNV numbers for three additional O. australiensis genotypes based on Illumina re-sequencing. Although genetic similarity reflected geographical separation, the density of SNVs also correlated with our previous report on variations in salinity tolerance. This genome re-confirms the genetic remoteness of the O. australiensis lineage within the O. officinalis genome complex. Assembly of a high-quality genome for O. australiensis provides an important resource for the discovery of critical genes involved in development and stress tolerance.Aaron L. Phillips, Scott Ferguson, Nathan S. Watson, Haigh, Ashley W. Jones, Justin O. Borevitz, Rachel A. Burton, Brian J. Atwel
Hydrophobic and ionic-interactions in bulk and confined water with implications for collapse and folding of proteins
Water and water-mediated interactions determine thermodynamic and kinetics of
protein folding, protein aggregation and self-assembly in confined spaces. To
obtain insights into the role of water in the context of folding problems, we
describe computer simulations of a few related model systems. The dynamics of
collapse of eicosane shows that upon expulsion of water the linear hydrocarbon
chain adopts an ordered helical hairpin structure with 1.5 turns. The structure
of dimer of eicosane molecules has two well ordered helical hairpins that are
stacked perpendicular to each other. As a prelude to studying folding in
confined spaces we used simulations to understand changes in hydrophobic and
ionic interactions in nano droplets. Solvation of hydrophobic and charged
species change drastically in nano water droplets. Hydrophobic species are
localized at the boundary. The tendency of ions to be at the boundary where
water density is low increases as the charge density decreases. Interaction
between hydrophobic, polar, and charged residue are also profoundly altered in
confined spaces. Using the results of computer simulations and accounting for
loss of chain entropy upon confinement we argue and then demonstrate, using
simulations in explicit water, that ordered states of generic amphiphilic
peptide sequences should be stabilized in cylindrical nanopores
Candidate genes for field resistance to cassava brown streak disease revealed through the analysis of multiple data sources
Open Access JournalCassava (Manihot esculenta Crantz) is a food and industrial storage root crop with substantial potential to contribute to managing risk associated with climate change due to its inherent resilience and in providing a biodegradable option in manufacturing. In Africa, cassava production is challenged by two viral diseases, cassava brown streak disease (CBSD) and cassava mosaic disease. Here we detect quantitative trait loci (QTL) associated with CBSD in a biparental mapping population of a Tanzanian landrace, Nachinyaya and AR37-80, phenotyped in two locations over three years. The purpose was to use the information to ultimately facilitate either marker-assisted selection or adjust weightings in genomic selection to increase the efficiency of breeding. Results from this study were considered in relation to those from four other biparental populations, of similar genetic backgrounds, that were phenotyped and genotyped simultaneously. Further, we investigated the co-localization of QTL for CBSD resistance across populations and the genetic relationships of parents based on whole genome sequence information. Two QTL on chromosome 4 for resistance to CBSD foliar symptoms and one on each of chromosomes 11 and 18 for root necrosis were of interest. Of significance within the candidate genes underlying the QTL on chromosome 4 are Phenylalanine ammonia-lyase (PAL) and Cinnamoyl-CoA reductase (CCR) genes and three PEPR1-related kinases associated with the lignin pathway. In addition, a CCR gene was also underlying the root necrosis-resistant QTL on chromosome 11. Upregulation of key genes in the cassava lignification pathway from an earlier transcriptome study, including PAL and CCR, in a CBSD-resistant landrace compared to a susceptible landrace suggests a higher level of basal lignin deposition in the CBSD-resistant landrace. Earlier RNAscope® in situ hybridisation imaging experiments demonstrate that cassava brown streak virus (CBSV) is restricted to phloem vessels in CBSV-resistant varieties, and phloem unloading for replication in mesophyll cells is prevented. The results provide evidence for the involvement of the lignin pathway. In addition, five eukaryotic initiation factor (eIF) genes associated with plant virus resistance were found within the priority QTL regions
Inclusive eta' Production from the Upsilon(1S)
Using the CLEO II detector at CESR, we measure the eta' - gluon - gluon
form-factor in Y(1S) decays. This form-factor especially at large eta' energies
may provide an explanation of the large rate for B -> Xs eta'. Our data do not
support a large anomalous coupling at higher q^2 and thus the large eta' rate
remains a mystery, possibly requiring a non-Standard Model explanation.Comment: 14 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, submitted to PR
Model-consistent estimation of the basic reproduction number from the incidence of an emerging infection
We investigate the merit of deriving an estimate of the basic reproduction number \documentclass[12pt]{minimal}
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\end{document} with estimates incorporating additional model assumptions, and determine the circumstances under which the different estimates are consistent. We show that one has to be careful when using observed exponential growth rates to derive an estimate of \documentclass[12pt]{minimal}
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, and we quantify the discrepancies that arise
Low-mass pre--main-sequence stars in the Magellanic Clouds
[Abridged] The stellar Initial Mass Function (IMF) suggests that sub-solar
stars form in very large numbers. Most attractive places for catching low-mass
star formation in the act are young stellar clusters and associations, still
(half-)embedded in star-forming regions. The low-mass stars in such regions are
still in their pre--main-sequence (PMS) evolutionary phase. The peculiar nature
of these objects and the contamination of their samples by the evolved
populations of the Galactic disk impose demanding observational techniques for
the detection of complete numbers of PMS stars in the Milky Way. The Magellanic
Clouds, the companion galaxies to our own, demonstrate an exceptional star
formation activity. The low extinction and stellar field contamination in
star-forming regions of these galaxies imply a more efficient detection of
low-mass PMS stars than in the Milky Way, but their distance from us make the
application of special detection techniques unfeasible. Nonetheless, imaging
with the Hubble Space Telescope yield the discovery of solar and sub-solar PMS
stars in the Magellanic Clouds from photometry alone. Unprecedented numbers of
such objects are identified as the low-mass stellar content of their
star-forming regions, changing completely our picture of young stellar systems
outside the Milky Way, and extending the extragalactic stellar IMF below the
persisting threshold of a few solar masses. This review presents the recent
developments in the investigation of PMS stars in the Magellanic Clouds, with
special focus on the limitations by single-epoch photometry that can only be
circumvented by the detailed study of the observable behavior of these stars in
the color-magnitude diagram. The achieved characterization of the low-mass PMS
stars in the Magellanic Clouds allowed thus a more comprehensive understanding
of the star formation process in our neighboring galaxies.Comment: Review paper, 26 pages (in LaTeX style for Springer journals), 4
figures. Accepted for publication in Space Science Review
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