16 research outputs found
Lymphocyte Development: Intrinsic checkpoints for lineage progression
AbstractA new T-cell receptor α-chain-like molecule has been identified in precursor T cells. This protein may be part of a receptor complex that induces T-cell maturation
Contribution of myeloid cell to the development of autoimmunity in Lyn-deficient mice.
In this study we investigated how myeloid leukocytes may contribute to the breakdown of tolerance in lyn -/- mice. In particular, we have characterized the production of BAFF by lyn -/- myeloid cells and its possible involvement in the development of autoimmune disorders in this model
Distinct role for MyD88 signaling in myeloid cells and stromal cells in an imiquimod-induced mouse model of psoriasis.
These data demonstrate that MyD88 signaling in innate myeloid cells plays an important role on disease propagation and exacerbation in the IMQ-induced model of psoriasis. However, MyD88 signaling is dispensable for the initiation of keratinocyte-mediated inflammatory responses
Distinct role for MyD88 signaling in myeloid cells and stromal cells in an imiquimod-induced mouse model of psoriasis
In this data we demonstrate that MyD88 signaling in innate myeloid cells plays an important role on disease propagation and exacerbation in the IMQ-induced model of psoriasis. However, MyD88 signaling is dispensable for the initiation of keratinocyte-mediated inflammatory responses in this model
Distinct role for MyD88 signaling in myeloid cells and stromal cells in an imiquimod-induced mouse model of psoriasis.
Our study demonstrates that MyD88 signaling in innate myeloid cells plays an important role on disease propagation and exacerbation in the IMQ-induced model of psoriasis. However, MyD88 signaling is dispensable for the initiation of keratinocyte-mediated inflammatory responses