Facile Hydrogen Evolution Reaction on WO3Nanorods

Tungsten trioxide nanorods have been generated by the thermal decomposition (450 °C) of tetrabutylammonium decatungstate. The synthesized tungsten trioxide (WO3) nanorods have been characterized by XRD, Raman, SEM, TEM, HRTEM and cyclic voltammetry. High resolution transmission electron microscopy and X-ray diffraction analysis showed that the synthesized WO3nanorods are crystalline in nature with monoclinic structure. The electrochemical experiments showed that they constitute a better electrocatalytic system for hydrogen evolution reaction in acid medium compared to their bulk counterpart

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Forecasting of COVID-19 cases using deep learning models: Is it reliable and practically significant?

The ongoing outbreak of the COVID-19 pandemic prevails as an ultimatum to the global economic growth and henceforth, all of society since neither a curing drug nor a preventing vaccine is discovered. The spread of COVID-19 is increasing day by day, imposing human lives and economy at risk. Due to the increased enormity of the number of COVID-19 cases, the role of Artificial Intelligence (AI) is imperative in the current scenario. AI would be a powerful tool to fight against this pandemic outbreak by predicting the number of cases in advance. Deep learning-based time series techniques are considered to predict world-wide COVID-19 cases in advance for short-term and medium-term dependencies with adaptive learning. Initially, the data pre-processing and feature extraction is made with the real world COVID-19 dataset. Subsequently, the prediction of cumulative confirmed, death and recovered global cases are modelled with Auto-Regressive Integrated Moving Average (ARIMA), Long Short-Term Memory (LSTM), Stacked Long Short-Term Memory (SLSTM) and Prophet approaches. For long-term forecasting of COVID-19 cases, multivariate LSTM models is employed. The performance metrics are computed for all the models and the prediction results are subjected to comparative analysis to identify the most reliable model. From the results, it is evident that the Stacked LSTM algorithm yields higher accuracy with an error of less than 2% as compared to the other considered algorithms for the studied performance metrics. Country-specific analysis and city-specific analysis of COVID-19 cases for India and Chennai, respectively, are predicted and analyzed in detail. Also, statistical hypothesis analysis and correlation analysis are done on the COVID-19 datasets by including the features like temperature, rainfall, population, total infected cases, area and population density during the months of May, June, July and August to find out the best suitable model. Further, practical significance of predicting COVID-19 cases is elucidated in terms of assessing pandemic characteristics, scenario planning, optimization of models and supporting Sustainable Development Goals (SDGs)