3 research outputs found
Effects of disorder on the wave front depinning transition in spatially discrete systems
Pinning and depinning of wave fronts are ubiquitous features of spatially
discrete systems describing a host of phenomena in physics, biology, etc. A
large class of discrete systems is described by overdamped chains of nonlinear
oscillators with nearest-neighbor coupling and subject to random external
forces. The presence of weak randomness shrinks the pinning interval and it
changes the critical exponent of the wave front depinning transition from 1/2
to 3/2. This effect is derived by means of a recent asymptotic theory of the
depinning transition, extended to discrete drift-diffusion models of transport
in semiconductor superlattices and confirmed by numerical calculations.Comment: 4 pages, 3 figures, to appear as a Rapid Commun. in Phys. Rev.
Calcium waves in a model with a random spatially discrete distribution of Ca2+ release sites
A bidomain threshold model of propagating calcium waves
We present a bidomain fire-diffuse-fire model that facilitates mathematical analysis of propagating waves of elevated intracellular calcium (Ca) in living cells. Modelling Ca release as a threshold process allows the explicit construction of travelling wave solutions to probe the dependence of Ca wave speed on physiologically important parameters such as the threshold for Ca release from the endoplasmic reticulum (ER) to the cytosol, the rate of Ca resequestration from the cytosol to the ER, and the total [Ca] (cytosolic plus ER). Interestingly, linear stability analysis of the bidomain fire-diffuse-fire model predicts the onset of dynamic wave instabilities leading to the emergence of Ca waves that propagate in a back-and-forth manner. Numerical simulations are used to confirm the presence of these so-called "tango waves" and the dependence of Ca wave speed on the total [Ca].
The original publication is available at www.springerlink.com (Journal of Mathematical Biology