33 research outputs found
Phase- coherent comparison of two optical frequency standards over 146 km using a telecommunication fiber link
We have explored the performance of two "dark fibers" of a commercial
telecommunication fiber link for a remote comparison of optical clocks. The two
fibers, linking the Leibniz University of Hanover (LUH) with the
Physi-kalisch-Technische Bundesanstalt (PTB) in Braunschweig, are connected in
Hanover to form a total fiber length of 146 km. At PTB the performance of an
optical frequency standard operating at 456 THz was imprinted to a cw trans-fer
laser at 194 THz, and its frequency was transmitted over the fiber. In order to
detect and compensate phase noise related to the optical fiber link we have
built a low-noise optical fiber interferometer and investigated noise sources
that affect the overall performance of the optical link. The frequency
stability at the remote end has been measured using the clock laser of PTB's
Yb+ frequency standard operating at 344 THz. We show that the frequency of a
frequency-stabilized fiber laser can be transmitted over a total fiber length
of 146 km with a relative frequency uncertainty below 1E-19, and short term
frequency instability given by the fractional Allan deviation of
sy(t)=3.3E-15/(t/s)
Computational pan-genomics: Status, promises and challenges
Many disciplines, from human genetics and oncology to plant breeding, microbiology and virology, commonly face the challenge of analyzing rapidly increasing numbers of genomes. In case of Homo sapiens, the number of sequenced genomes will approach hundreds of thousands in the next few years. Simply scaling up established bioinformatics pipelines will not be sufficient for leveraging the full potential of such rich genomic data sets. Instead, novel, qualitatively different Computational methods and paradigms are needed.We will witness the rapid extension of Computational pan-genomics, a new sub-area of research in Computational biology. In this article, we generalize existing definitions and understand a pangenome as any collection of genomic sequences to be analyzed jointly or to be used as a reference. We examine already available approaches to construct and use pan-genomes, discuss the potential benefits of future technologies and methodologies and review open challenges from the vantage point of the above-mentioned biological disciplines. As a prominent example for a Computational paradigm shift, we particularly highlight the transition from the representation of reference genomes as strings to representations
State of the world’s plants and fungi 2020
Kew’s State of the World’s Plants and Fungi project provides assessments of our current knowledge of the diversity of plants and fungi on Earth, the global threats that they face, and the policies to safeguard them. Produced in conjunction with an international scientific symposium, Kew’s State of the World’s Plants and Fungi sets an important international standard from which we can annually track trends in the global status of plant and fungal diversity