Pancreatic Islets Isolated From β2 Adrenergic Receptor Knockout Mice Show Reduced Insulin Secretion In Response To Nutrients [ilhotas Pancreaśticas Isoladas De Camundongos Com Deleção Do Receptor Adrenérgico β2 Apresenta Reduzida Secreção De Insulina Em Resposta A Nutrientes]

Activation of β2 adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β2 knockout (β2KO) mice. β2KO mice showed reduced body weight, fasting hypoglycaemia associate to a similar fasting insulinemia compared to control. β2KO mice also showed reduced glucose tolerance despite the higher sensitivity to insulin. Glucose-induced insulin secretion was impaired in pancreatic islets isolated from β2KO mice. Leucine-induced (20mM) insulin secretion was diminished in pancreatic islets isolated from β2KO mice when compared to control one. The depolarizing effect of KCl on insulin secretion was also impaired in pancreatic islets from β2KO mice. 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