Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation

Advances in Plasmaspheric Wave Research with CLUSTER and IMAGE Observations

International audienceThis paper highlights significant advances in plasmaspheric wave research with Cluster and Image observations. This leap forward was made possible thanks to the new observational capabilities of these space missions. On one hand, the multipoint view of the four Cluster satellites, a unique capability, has enabled the estimation of wave characteristics impossible to derive from single spacecraft measurements. On the other hand, the Image experiments have enabled to relate large-scale plasmaspheric density structures with wave observations and provide radio soundings of the plasmasphere with unprecedented details. After a brief introduction on Cluster and Image wave instrumentation, a series of sections, each dedicated to a specific type of plasmaspheric wave, put into context the recent advances obtained by these two revolutionary missions