Phytochemical, Proximate Analysis and Mineral Composition of Aqueous Crude Extract of Ficus Asperifolia Miq

To determine the chemical constituents, proximate, phytochemical analysis and mineral composition of the crude aqueous extract of the leaves of Ficus asperifolia. The extracts were subjected to proximate and phytochemical screening. The mineral contents were determined using standard biochemical methods and equipment. Phytochemical studies carried out on aqueous extract of Ficus asperifolia leaves showed the presence of alkaloid, saponin, phenol, tannin, cardiac glycoside, steroid, cardenolides and phlobatannins while terpenes, flavonoids, anthraquinones and chalcones were not detected. Analyses showed that the sample has high level of Carbohydrate (42.64%), moderate amount of Crude Fibre and Protein (18.41 and 14.73%), respectively and little amount of Ash content (9.78%) and Crude Fat (3.16%). Also a considerable level (11.29%) of moisture was shown. This composition shows that the sample could be a good source of Carbohydrate, Dietary Fibre and Protein. Sodium and Potassium content (0.185±0.002 and 0.367±0.007%), respectively indicates the tendency of Ficus asperifolia to be able to regulate or control the osmotic balance of the body fluid as well as body pH. Ficus asperifolia is also found to be rich in Phosphorus (0.349±0.002%) and Calcium (0.203±0.002%), which is essential for bone formation. Magnesium, (0.428±0.003%) is also present, which could help to lower the blood pressure. Antioxidant minerals Zinc (64.45±0.15 mg/kg), Iron (7.00±0.20 mg/kg), Copper (13.35±0.15 mg/kg) and Selenium (0.0027±0.01 mg/kg) are also present. Our findings therefore, suggest that there is an indication that Ficus asperifolia contains important phytochemicals, proximate and mineral compounds that may be linked to its beneficial effects on health

Psychotropic Medications and QTc Parameters in a Nigerian Cohort

Aims: Evidence is increasing to indicate that individuals with mental illness may be at risk of premature death. We studied the prevalence of QTc prolongation, QT dispersion (QTd) and cardiac arrhythmias in patients on psychotropic drugs. Study Design: Cross-sectional study. Place and Duration of Study: Department of Medicine and Department of Behavioral Sciences, University of Ilorin Teaching Hospital, Nigeria Between Januaryand June 2010. Methodology: One hundred and ninety-one consecutive patients on psychotropic medications with 121 controls were studied. All the subjects had detailed clinical examination and resting electrocardiogram (ECG) at 25mm/sec. QTc was determined using Bazett formula and QTd by subtracting shortest from longest QTc in 12-lead ECG. Results: Mean QTc of the patients (450±46msc) was longer (p=0.0001) than that of the controls (390±27msc) but mean QTd was similar (p=0.13) in both groups. QTc was prolonged in 68(35.6%) patients compared to 11(9.1%) controls, p=0.0001. LVH, arrhythmias and abnormal T-wave morphology occurred more (p=0.01, 0.01 and 0.001 respectively) in the patients than controls. Age, duration of treatment and total daily doses of antipsychotics were independent predictors of QTc. Cardiac arrhythmias were seen in 24.1% of the patients but none had ventricular arrhythmias. Conclusion: Psychotropic drug use is a risk factor for QTc prolongation and cardiac arrhythmias. We suggest periodic electrocardiography, discourage polypharmacy and recommend drug holiday in stable patients

Quality Evaluation of Wheat and Defatted Cashew Nut-Based Cookies

The effect of substituting defatted cashew nut flour for wheat flour on the functional properties of wheat and defatted cashew nut flour blends, and cookies quality were studied. The bulk density, water absorption, oil absorption, foaming and emulsion capacities of the blends ranged from 0.68 to 0.74 g/cm3, 1.05 to 1.10 g/g, 0.98 to 2.07 g/g, 7.51 to 11.43% and 58.67 to 73.33% respectively. Peak viscosity, trough viscosity, breakdown viscosity, set back viscosity, final viscosity, pasting temperature and peak time ranged from 148.05 to 231.30 RVU, 112.55 to 152.60 RVU, 35.50 to 78.70 RVU, 178.60 to 267.05 RVU, 66.05 to 114.45 RVU, 86.38 to 89.65 oC and 5.53 to 6.05 min respectively. Moisture, protein, fat, fibre, ash, carbohydrate and energy value ranged from 12.01 to 12.62 %, 13.00 to 28.00 %, 16.49 to 22.96%, 0.10 to 1.63%, 1.00 to 1.97%, 34.32 to 56.43% and 426.13 to 455.92 kcal 100/g, respectively. Mineral contents (calcium, magnesium, iron, zinc and phosphorus) increased with addition of defatted cashew nut flour. The result of the sensory evaluation showed that substitution of up to 20% cashew nut flour is generally acceptable. The addition of defatted cashew nut flour increased significantly the ferric reducing antioxidant power, 1, 1-dipenyly-2-picryl-hdrazil (DPPH) and 2, 2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and total phenolic content of composite the cookie compared to control. Keywords: Defatted cashew nut, functional properties, physicochemical properties, sensory attributes cookies

Clinical Presentations and Characteristics of Confirmed Covid-19 Patients over a 1-Year Period in a Private Health Facility in Ilorin, North-Central Nigeria

The first case of COVID-19 in Nigeria was confirmed on February 27, 2020.  Since then, many studies from government designated isolation centers have described the characteristics of patients with Covid-19. Even though COVID-19 testing and management are exclusively carried out at the NCDC-approved centers, majority of patients are referred from primary care facilities, both public and private owned. To our knowledge, there has been no studies regarding Covid-19 disease among the patients served by these centers. Our aim is to describe the clinical characteristics and outcome of COVID-19 cases seen at Olanrewaju Hospital, Ilorin, North Central Nigeria. This is a descriptive retrospective study of patients with confirmed COVID-19 seen over a one-year period. Records of all patients that tested positive using the real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) were retrieved to extract relevant information. Data was analyzed using Epi Info 7.48 patients were analyzed. The mean age (standard deviation) was 50.0 years (17.89). Male sex predominates (58.3% vs 41.7%). Majority of patients were symptomatic (93.7%). Fever was most common presentation (75.6%). Shortness of breath was experienced by 11 patients (24.4%). Co-morbidities were found among 75% of the patients with hypertension being the commonest (45.9%). There were 6 deaths (12.5%), 5 of which occurred in the older age patients. Case fatality rate was significantly higher during the first wave than during the second wave 40% vs 5.6%, p < 0.05. The male gender, co-morbidities and older age groups are particularly prone to severe covid-19 infection with poorer outcome

MANAGEMENT OF A CHRONIC NECROTIZING WOUND IN A DOG USING NATURAL HONEY THERAPY

Infected skin wounds are common in pet animals. Following an infected severe bite wound in a dog with marked necrotic aftermath, natural honey was successfully used alongside systemic antibiotic therapy to hasten healing. The condition improved with speed and regeneration of skin tissue, avoiding sloughing. The wound took 168 days to heal and to form a scar. Natural honey can be considered as a wound management tool, as it is both highly effective, can render a low cost therapy and less managemental expenditure compared to other specialized therapies and techniques

Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries

Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($). Results: High FiO2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO2 was$216 compared with $222 for low FiO2 leading to a −$6 (95% confidence interval [CI]: −$13 to −$1) difference in costs. In India, the average cost for high FiO2 was $184 compared with$195 for low FiO2 leading to a −$11 (95$15 to −$6) difference in costs. In South Africa, the average cost for high FiO2 was$1164 compared with $1257 for low FiO2 leading to a −$93 (95% CI: −$132 to −$65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this