77,894 research outputs found

    Ultrasoft NLL Running of the Nonrelativistic O(v) QCD Quark Potential

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    Using the nonrelativistic effective field theory vNRQCD, we determine the contribution to the next-to-leading logarithmic (NLL) running of the effective quark-antiquark potential at order v (1/mk) from diagrams with one potential and two ultrasoft loops, v being the velocity of the quarks in the c.m. frame. The results are numerically important and complete the description of ultrasoft next-to-next-to-leading logarithmic (NNLL) order effects in heavy quark pair production and annihilation close to threshold.Comment: 25 pages, 7 figures, 3 tables; minor modifications, typos corrected, references added, footnote adde

    Massive Hermitian Gravity

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    Einstein-Strauss Hermitian gravity was recently formulated as a gauge theory where the tangent group is taken to be the pseudo-unitary group instead of the orthogonal group. A Higgs mechanism for massive gravity was also formulated. We generalize this construction to obtain massive Hermitian gravity with the use of a complex Higgs multiplet. We show that both the graviton and antisymmetric tensor acquire the same mass. At the linearized level, the theory is ghost free around Minkowski background and describes a massive graviton with five degrees of freedom and an antisymmetric field with three degrees of of freedom. We determine the strong coupling scales for these degrees of freedom and argue that the potential nonlinear ghosts, if they exist, have to decouple from the gravitational degrees of freedom in strong coupling regime.Comment: 10 page

    Rule Extraction, Fuzzy ARTMAP, and Medical Databases

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    This paper shows how knowledge, in the form of fuzzy rules, can be derived from a self-organizing supervised learning neural network called fuzzy ARTMAP. Rule extraction proceeds in two stages: pruning removes those recognition nodes whose confidence index falls below a selected threshold; and quantization of continuous learned weights allows the final system state to be translated into a usable set of rules. Simulations on a medical prediction problem, the Pima Indian Diabetes (PID) database, illustrate the method. In the simulations, pruned networks about 1/3 the size of the original actually show improved performance. Quantization yields comprehensible rules with only slight degradation in test set prediction performance.British Petroleum (89-A-1204); Defense Advanced Research Projects Agency (AFOSR-90-0083, ONR-N00014-92-J-4015); National Science Foundation (IRI-90-00530); Office of Naval Research (N00014-91-J-4100); Air Force Office of Scientific Research (90-0083); Institute of Systems Science (National University of Singapore

    Characterization of Saturn's bow shock: magnetic field observations of quasi-perpendicular shocks

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    Collisionless shocks vary drastically from terrestrial to astrophysical regimes resulting in radically different characteristics. This poses two complexities. First, separating the influences of these parameters on physical mechanisms such as energy dissipation. Second, correlating observations of shock waves over a wide range of each parameter, enough to span across different regimes. Investigating the latter has been restricted since the majority of studies on shocks at exotic regimes (such as supernova remnants) have been achieved either remotely or via simulations, but rarely by means of in situ observations. Here we present the parameter space of MA bow shock crossings from 2004 to 2014 as observed by the Cassini spacecraft. We find that Saturn's bow shock exhibits characteristics akin to both terrestrial and astrophysical regimes (MA of order 100), which is principally controlled by the upstream magnetic field strength. Moreover, we determined the θBn of each crossing to show that Saturn's (dayside) bow shock is predominantly quasi-perpendicular by virtue of the Parker spiral at 10 AU. Our results suggest a strong dependence on MA in controlling the onset of physical mechanisms in collisionless shocks, particularly nontime stationarity and variability. We anticipate that our comprehensive assessment will yield deeper insight into high MA collisionless shocks and provide a broader scope for understanding the structures and mechanisms of collisionless shocks

    Gravity with de Sitter and Unitary Tangent Groups

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    Einstein Gravity can be formulated as a gauge theory with the tangent space respecting the Lorentz symmetry. In this paper we show that the dimension of the tangent space can be larger than the dimension of the manifold and by requiring the invariance of the theory with respect to 5d Lorentz group (de Sitter group) Einstein theory is reproduced unambiguously. The other possibility is to have unitary symmetry on a complex tangent space of the same dimension as the manifold. In this case the resultant theory is Einstein-Strauss Hermitian gravity. The tangent group is important for matter couplings. We show that in the de Sitter case the 4 dimensional space time vector and scalar are naturally unified by a hidden symmetry being components of a 5d vector in the tangent space. With a de Sitter tangent group spinors can exist only when they are made complex or taken in doublets in a way similar to N=2 supersymmetry.Comment: 23 pages, one reference added.To be published in JHE

    Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats

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    Background: Vectors based on adeno-associated virus-8 (AAV8) have shown efficiency and efficacy for liver-directed gene therapy protocols following intravascular injection, particularly in relation to haemophilia gene therapy. AAV8 has also been proposed for gene therapy targeted at skeletal and cardiac muscle, again via intravascular injection. It is important to assess vector targeting at the level of virion accumulation and transgene expression in multiple species to ascertain potential issues relating to species variation in infectivity profiles. Methods: We used AAV8 vectors expressing human factor IX (FIX) from the liver-specific LP-1 promoter and administered this virus via the intravascular route of injection into 12 week old Wistar Kyoto rats. We assessed FIX levels in serum by ELISA and transgene expression at sacrifice by immunohistochemistry using anti-FIX antibodies. Vector DNA levels in organs we determined by real time PCR. Results: Administration of 1 × 1011 or 5 × 1011 scAAV8-LP1-hFIX vector particles/rat resulted in efficient production of physiological hFIX levels, respectively in blood assessed 4 weeks post-injection. This was maintained for the 4 month duration of the study. At 4 months we observed liver persistence of vector with minimal non-hepatic distribution. Conclusion: Our results demonstrate that AAV8 is a robust vector for delivering therapeutic genes into rat liver following intravascular injection
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