461 research outputs found
Adaptive Eigenvalue Computation - Complexity Estimates
This paper is concerned with the design and analysis of a fully adaptive
eigenvalue solver for linear symmetric operators. After transforming the
original problem into an equivalent one formulated on , the space of
square summable sequences, the problem becomes sufficiently well conditioned so
that a gradient type iteration can be shown to reduce the error by some fixed
factor per step. It then remains to realize these (ideal) iterations within
suitable dynamically updated error tolerances. It is shown under which
circumstances the adaptive scheme exhibits in some sense asymptotically optimal
complexity.Comment: submitted to Math. Com
Gamma-widths, lifetimes and fluctuations in the nuclear quasi-continuum
Statistical -decay from highly excited states is determined by the
nuclear level density (NLD) and the -ray strength function
(SF). These average quantities have been measured for several nuclei
using the Oslo method. For the first time, we exploit the NLD and SF to
evaluate the -width in the energy region below the neutron binding
energy, often called the quasi-continuum region. The lifetimes of states in the
quasi-continuum are important benchmarks for a theoretical description of
nuclear structure and dynamics at high temperature. The lifetimes may also have
impact on reaction rates for the rapid neutron-capture process, now
demonstrated to take place in neutron star mergers.Comment: CGS16, Shanghai 2017, Proceedings, 5 pages, 3 figure
New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions
Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation that affects various organs leading to a reduced quality of life. The condition often requires enduring immunosuppressive therapy, which can also lead to the development of severe side effects. Several approaches including small molecule inhibitors, antibodies, cytokines, and cellular therapies are now being developed for the treatment of cGvHD, and some of these therapies have been or are currently tested in clinical trials. In this review, we discuss these emerging therapies with particular emphasis on tyrosine kinase inhibitors (TKIs). TKIs are a class of compounds that inhibits tyrosine kinases, thereby preventing the dissemination of growth signals and activation of key cellular proteins that are involved in cell growth and division. Because they have been shown to inhibit key kinases in both B cells and T cells that are involved in the pathophysiology of cGvHD, TKIs present new promising therapeutic approaches. Ibrutinib, a Bruton tyrosine kinase (Btk) inhibitor, has recently been approved by the Food and Drug Administration (FDA) in the United States for the treatment of adult patients with cGvHD after failure of first-line of systemic therapy. Also, Janus Associated Kinases (JAK1 and JAK2) inhibitors, such as itacitinib (JAK1) and ruxolitinib (JAK1 and 2), are promising in the treatment of cGvHD. Herein, we present the current status and future directions of the use of these new drugs with particular spotlight on their targeting of specific intracellular signal transduction cascades important for cGvHD, in order to shed some light on their possible mode of actions
Statistical properties of Pu, and Pu(n,) cross section calculation
The level density and gamma-ray strength function (gammaSF) of 243Pu have
been measured in the quasi-continuum using the Oslo method. Excited states in
243Pu were populated using the 242Pu(d,p) reaction. The level density closely
follows the constant-temperature level density formula for excitation energies
above the pairing gap. The gammaSF displays a double-humped resonance at low
energy as also seen in previous investigations of actinide isotopes. The
structure is interpreted as the scissors resonance and has a centroid of
omega_{SR}=2.42(5)MeV and a total strength of B_{SR}=10.1(15)mu_N^2, which is
in excellent agreement with sum-rule estimates. The measured level density and
gammaSF were used to calculate the 242Pu(n,gamma) cross section in a neutron
energy range for which there were previously no measured data.Comment: 9 pages, 8 figure
Chromatin accessibility dynamics across C. elegans development and ageing
An essential step for understanding the transcriptional circuits that control development and physiology is the global identification and characterization of regulatory elements. Here we present the first map of regulatory elements across the development and ageing of an animal, identifying 42,245 elements accessible in at least one C. elegans stage. Based on nuclear transcription profiles, we define 15,714 protein-coding promoters and 19,231 putative enhancers, and find that both types of element can drive orientation-independent transcription. Additionally, more than 1000 promoters produce transcripts antisense to protein coding genes, suggesting involvement in a widespread regulatory mechanism. We find that the accessibility of most elements changes during development and/or ageing and that patterns of accessibility change are linked to specific developmental or physiological processes. The map and characterization of regulatory elements across C. elegans life provides a platform for understanding how transcription controls development and ageing
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