Development of neural network model of the multiparametric technological object

At present, there are a large number of methods for identifying the technological objects on the basis of data of their industrial operation [1-3]. The most promising direction is the construction of a model, which will allow to take into account the multifactorial nature of the object, and the nonlinearity of interrelation between variables. This will make it possible to control the object, taking into account the change in its states, and based on the current data,to predict the change in the output value with different input characteristics[4-6]. All this will provide the opportunity to create an operating system, based on the currently measured technological indicators. In order to implement this approach, a comparative study of the regression analysis models, using polynomials of various types and neural network algorithms, for the synthesis of a complex technological unit model, was carried out in the work. In the regression analysis, the following models were investigated: polynomials, linear, fractional and exponential functions, Kolmogorov-Gabor polynomial. In the process of the research of neural networks to solve this problem, their structure was varied, with subsequent learning according to the Levenberg-Marcardt algorithm. In the process of simulation of the object models in the Matlab package, the degree of similarity of the outputs for each of the obtained models and the actual output of the object were estimated. Quadratic criterion and the coefficient of correlation were calculated, that made it possible to judge the accuracy of the constructed models. The best structure of the model was established for identifying a complex multiparameter object, using the example of statistics for the operation of a ball mill.It was a network with three hidden layers and 50, 35 and 25 neurons in them, with activation functions, respectively by layers - hyperbolic tangent, sigmoid function in 2 layers, and a linear activation function in the output layer. The vector, including 15 parameters, was supplied to the network input: the volume of ore supply to the mill, the volume of water supply to the mill and the mill’strommel, the signals with the first-, the second-, and the thirdorder lags, and the signal of current with the first-, the second-, and the third-order lags. This approach to identification has increased the accuracy of the object model, that ultimately will affect the quality of the developed control system of the unit as a whole, allowing to improve the quality of the ball millcontrol

A study of cell membranes in nasal epithelial cells from patients with chronic rhinosinusitis with nasal polyps by means of a fluorescent probe

Aim. To assess the state of membranes in nasal epithelial cells obtained from the patients with chronic rhinosinusitis with nasal polyps (CRSwNP) with the help of the fluorescent probe 2-(2ʹ-ОН-phenyl)-5-phenyl-1,3-oxazole. Methods. The state of membrane phospholipid bilayer in suspensions of nasal epithelial cells isolated from ten patients with CRSwNP was evaluated using the fluorescent probe 2-(2ʹ-ОН-phenyl)-5-phenyl-1,3-oxazole that reacts on the physico-chemical properties of its microenvironment. Changes in fluorescence spectra were determined using a Thermo Scientific Lumina fluorescence spectrometer (Thermo Fisher Scientific) 1 hour after the addition of the probe to nasal epithelial cell suspensions. Results. CRSwNP was found to be associated with a higher rate of nasal epithelial cell membrane hydration in the region of phospholipid glycerol moiety, carbonyl groups and aliphatic chains of fatty acids attached to the carbonyl groups. Conclusion. Our findings suggest that CRSwNP is accompanied by the elevated hydration rate of the most polar region, namely polar heads of phospholipids of nasal epithelial cell membranes

A study of cell membranes in nasal epithelial cells from patients with chronic rhinosinusitis with nasal polyps by means of a fluorescent probe

Aim. To assess the state of membranes in nasal epithelial cells obtained from the patients with chronic rhinosinusitis with nasal polyps (CRSwNP) with the help of the fluorescent probe 2-(2ʹ-ОН-phenyl)-5-phenyl-1,3-oxazole. Methods. The state of membrane phospholipid bilayer in suspensions of nasal epithelial cells isolated from ten patients with CRSwNP was evaluated using the fluorescent probe 2-(2ʹ-ОН-phenyl)-5-phenyl-1,3-oxazole that reacts on the physico-chemical properties of its microenvironment. Changes in fluorescence spectra were determined using a Thermo Scientific Lumina fluorescence spectrometer (Thermo Fisher Scientific) 1 hour after the addition of the probe to nasal epithelial cell suspensions. Results. CRSwNP was found to be associated with a higher rate of nasal epithelial cell membrane hydration in the region of phospholipid glycerol moiety, carbonyl groups and aliphatic chains of fatty acids attached to the carbonyl groups. Conclusion. Our findings suggest that CRSwNP is accompanied by the elevated hydration rate of the most polar region, namely polar heads of phospholipids of nasal epithelial cell membranes

Хімія

The book presents the material for the study of fundamental discipline "Chemistry" in the undergraduate course. The manual provides concise theoretical material and includes many laboratory works. For the students of specialty "Oil, gas and condensate" and specialty "Management and administration of companies, trade and exchange activities". The book can be used during training of foreign students.Навчальний посібник складено для вивчення фундаментальної дисципліни "Хімія" в курсі бакалаврату. У посібнику стисло наведено теоретичний матеріал, є багато лабораторних робіт. Розраховано на студентів спеціальності "Добування нафти, газу та конденсату" і спеціальності "Управління та адміністрування підприємств, торгова та біржова діяльність". Оскільки посібник викладено англійською мовою, він може використовуватись у ході навчання студентів-іноземців

From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein

Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed. We sought to develop a novel model which could incorporate the effects of mutations on distance travelled and velocity. A mechanical model for the dynein mediated transport of endosomes is derived from first principles and solved numerically. The effects of variations in model parameter values are analysed to find those that have a significant impact on velocity and distance travelled. The model successfully describes the processivity of dynein and matches qualitatively the velocity profiles observed in experiments

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity

Phenomenological analysis of ATP dependence of motor protein

In this study, through phenomenological comparison of the velocity-force data of processive motor proteins, including conventional kinesin, cytoplasmic dynein and myosin V, we found that, the ratio between motor velocities of two different ATP concentrations is almost invariant for any substall, superstall or negative external loads. Therefore, the velocity of motor can be well approximated by a Michaelis-Menten like formula V=\atp k(F)L/(\atp +K_M), with $L$ the step size, and $k(F)$ the external load $F$ dependent rate of one mechanochemical cycle of motor motion in saturated ATP solution. The difference of Michaelis-Menten constant $K_M$ for substall, superstall and negative external load indicates, the ATP molecule affinity of motor head for these three cases are different, though the expression of $k(F)$ as a function of $F$ might be unchanged for any external load $F$. Verifications of this Michaelis-Menten like formula has also been done by fitting to the recent experimental data

CLINICAL EFFICACY OF ALBUMIN DIALYSIS THERAPY FOR PATIENTS WITH HEPATORENAL SYNDROME

34 patients (23 male, 11 female) in the age of 41–77 years (mean age 59,7 ± 4,2 years) with 2 type hepatorenal syndrome were included in the study. All patients were divided in 3 groups. The 1st group (n = 15) was treated by medical treatment, the 2nd group (n = 12) was treated by medical treatment and hemodiafiltration and the 3rd group (n = 7) – combined treatment with MARS therapy. Outcomes showed that combined therapy with addition of MARS provides positive results in treatment of the patients with 2 type hepatorenal syndrome