Evaluation of onset of pain relief from micronized aspirin in a dental pain model

A new formulation of a micronized acetylsalicylic acid swallowable tablet with an effervescent component (FR-aspirin) was evaluated in two independent studies using the dental impaction pain model. These clinical studies were performed to confirm the results of preclinical dissolution studies and human pharmacokinetic studies, which indicated an improved onset of analgesia without compromising duration of effect or safety. Study 1 evaluated a 650-mg dose of aspirin and Study 2 evaluated a 1,000-mg dose of aspirin. Both studies were double-blinded, parallel group and compared to regular aspirin (R-aspirin) and placebo. Speed of onset was measured by the double stopwatch method for time to both first perceptible relief and meaningful relief. In both studies, the FR-aspirin was significantly faster (p < 0.038–0.001) than both R-aspirin and placebo for both onset measures. There were no significant differences between FR-aspirin and R-aspirin for peak or total effects and both treatments were significantly better than placebo. For first perceptible relief, FR-aspirin onset was 19.8 and 16.3 min for 650 mg and 1,000 mg, respectively, compared to 23.7 and 20.0 for R-aspirin. For meaningful relief, FR-aspirin onset was 48.9 and 49.4 min for 650 mg and 1,000 mg, respectively, compared to 119.2 and 99.2 for R-aspirin. These efficacy studies clearly demonstrate that the onset of analgesic efficacy is dramatically improved by adding an effervescent component and micronized active ingredient to the swallowable tablet aspirin formulation. The enhanced onset did not adversely impact either the peak effect or duration of effect or tolerability compared to regular aspirin

Beam Dynamics Studies for SRF Photoinjectors

The SRF photoinjector combines the advantages of photo assisted production of high brightness, short electron pulses and high gradient, low loss continuous wave CW operation of a superconducting radiofrequency SRF cavity. The paper discusses beam dynamics considerations for ERL class applications of SRF photoinjectors. One case of particular interest is the design of the SRF photoinjector for BERLinPro, an ERL test facility demanding a high brightness beam with an emittance better than 1 mm mrad at 77 pC and average current of 100 m

Gastrointestinal Safety of Aspirin for a High-Dose, Multiple-Day Treatment Regimen: A Meta-Analysis of Three Randomized Controlled Trials

Background and Aim: Aspirin is a commonly used over-the-counter (OTC) agent for the symptomatic treatment of acute pain, fever, or the common cold, but data regarding safety in this context are limited. In order to characterize the safety of aspirin beyond single-dose or long-term use data, we conducted a meta-analysis of multiple-dose, multiple-day studies of OTC aspirin at a label-approved dosage. Methods: We conducted a meta-analysis of individual patient data from three Bayer-sponsored studies. The meta-analysis was performed in 2015; the individual studies were conducted between 2008 and 2012 and were of a randomized, parallel-group, placebo-controlled design. Patients received a minimum dosage of aspirin of 2000 mg/day over at least 3 days. The endpoints were patient-reported adverse events (AEs) with an emphasis on the system organ class gastrointestinal system. Event incidences were estimated and an analysis of the odds ratios (ORs) and risk differences (RDs) of aspirin versus placebo were performed. Results: Of the 819 patients included, 433 were treated with aspirin and 386 were treated with placebo. The majority of patients (85.7 %) received a median dose of aspirin of 3000 mg/day for 3 days. The incidence of the overall AEs was low and rates were comparable between the aspirin (10.9 %) and placebo (12.4 %) groups [OR: 0.86 (95 % confidence interval [CI] 0.56, 1.34); RD: -1.49 (95 % CI -6.01, 3.03)]. Gastrointestinal AEs were more common in subjects treated with aspirin (7.4 %) than with placebo (5.4 %), and although this difference did not reach statistical significance, a trend towards increased risk was observed with aspirin use [OR: 1.41 (95 % CI 0.78, 2.54); RD: 2.00 (95 % CI -1.35, 5.35)]. Nausea, upper abdominal pain, dyspepsia, and diarrhea were the most frequently reported gastrointestinal AEs. There were no reports of serious gastrointestinal complications such as bleeding, perforation, or ulceration.: Conclusions: The multiple-dose regimen of aspirin used for several days according to the OTC label is well-tolerated by otherwise healthy non-elderly subjects for short-term and symptomatic treatment of pain, fever, and the common cold. There were no reports of serious gastrointestinal complications in either of the groups

Performance of Historically Underrepresented Firms in the Public-Private Sector

This study examines the performance of historically underrepresented firms, which includes women-owned businesses and socially disadvantaged businesses. We examine performance in the context of securing public contracts and compare the performance of these historically underrepresented firms to those of non-minority small and large businesses. Utilizing a sample of all contracts awarded by the Johnson Space Center, a NASA directorate located in Houston, Texas, which identified 5,676 contracts totaling approximately $157 billion, we found that small businesses received around 63% of all contracts. The results indicate that more diverse firms received higher awards than specialists and that disadvantaged firms received higher dollar awards than general small businesses. In addition, women-owned businesses neither outperformed nor performed more poorly than general small business in the dollar amounts of contracts received, and they are neither more or less specialized than general small and large businesses. A discussion, practical implications, and future research ideas are also presented

Detecting and characterizing lateral phishing at scale

We present the first large-scale characterization of lateral phishing attacks, based on a dataset of 113 million employee-sent emails from 92 enterprise organizations. In a lateral phishing attack, adversaries leverage a compromised enterprise account to send phishing emails to other users, benefit-ting from both the implicit trust and the information in the hijacked user's account. We develop a classifier that finds hundreds of real-world lateral phishing emails, while generating under four false positives per every one-million employee-sent emails. Drawing on the attacks we detect, as well as a corpus of user-reported incidents, we quantify the scale of lateral phishing, identify several thematic content and recipient targeting strategies that attackers follow, illuminate two types of sophisticated behaviors that attackers exhibit, and estimate the success rate of these attacks. Collectively, these results expand our mental models of the 'enterprise attacker' and shed light on the current state of enterprise phishing attacks

Latency Analysis of TCP on an ATM Network

In this paper we characterize the latency of the BSD 4.4 alpha implementation of TCP on an ATM network. Latency reduction is a difficult task, and careful analysis is the first step towards reduction. We investigate the impact of both the network controller and the protocol implementation on latency. We find that a low latency network controller has a significant impact on the overall latency of TCP. We also characterize the impact on latency of some widely discussed improvements to TCP, such as header prediction and the combination of the checksum calculation with data copying.

Internet presence as a small business capability: the case of mobile optimization

This study reports on the mobile optimization efforts of 376 small and mid-sized enterprises (SME’s) operating in a suburban sector of a major U.S. metropolitan area.   We find that just under 50% of SME websites sampled were mobile optimized, defined as websites that render differently on a mobile browser than they do on a desktop browser.  Firms with a greater Internet presence and firms whose websites include basic, essential design elements are far more likely to have a mobile optimized website than those who do not.  Multi unit organizations, retailers, and healthcare oriented businesses are also each more likely to have a mobile optimized website

Wigner Glass, Spin-liquids, and the Metal-Insulator Transition

Recent experiments on the two dimensional electron gas in various semiconductor devices have revealed an unexpected metal-insulator transition and have challenged the previously held assumption that there is no such transition in two dimensions. While the experiments are still at the stage of rapid development, it is becoming evident that they cannot be understood from the conventional perspective of weak interactions. In the present paper, we propose the following. (1) The low-density insulating state is the Wigner Glass, a phase with quasi-long-range translational order and competing ferromagnetic and antiferromagnetic spin-exchange interactions. (2) The transition is the melting of this Wigner Glass, disorder being the agent allowing the transition to be second order. (3) Within the Wigner Glass phase, there are at least two, distinct magnetic ground-states, a ferromagnetic state at very low electron density and a spin-liquid state with a spin pseudo-gap at higher densities. (4) The metallic side of the transition is a non-Fermi liquid. These conclusions are encapsulated in Figure 1 which presents the proposed phase diagram as a function of disorder strength and density; we also suggest experimental signatures of the various phases and transitions.Comment: Revised manuscript 6 pages, 1 figure redrawn for clarity; discussion of experiments expande

Mobile Application Adoption by Young Adults: A Social Network Perspective

The use of mobile applications, defined as small programs that run on a mobile device and perform tasks ranging from banking to gaming and web browsing, is exploding. Within the past two years, the industry has grown from essentially nothing to a $2 billion marketplace, but adoption rates are still on the rise. Using network theory, this study examines how the adoption of mobile apps among young consumers is influenced by others in their social network. The results suggest that the likelihood of adoption and usage of mobile apps increases with their use by the consumer\u27s strongest relationship partner. In addition, the authors find marginal support for the hypothesis that the adoption of mobile apps will be more strongly influenced by a consumer\u27s social contacts (friends, compared to family members), possibly due to their closer similarity to the consumer. Managerial and theoretical implications are discussed