Intraoperative Local Field Potential Beta Power and Three-Dimensional Neuroimaging Mapping Predict Long-Term Clinical Response to Deep Brain Stimulation in Parkinson Disease: A Retrospective Study

background: directional deep brain stimulation (DBS) leads allow a fine-tuning control of the stimulation field, however, this new technology could increase the DBS programming time because of the higher number of the possible combinations used in directional DBS than in standard nondirectional electrodes. neuroimaging leads localization techniques and local field potentials (LFPs) recorded from DBS electrodes implanted in basal ganglia are among the most studied biomarkers for DBS programing. objective: this study aimed to evaluate whether intraoperative LFPs beta power and neuroimaging reconstructions correlate with contact selection in clinical programming of DBS in patients with Parkinson disease (PD). materials and methods: In this retrospective study, routine intraoperative LFPs recorded from all contacts in the subthalamic nucleus (STN) of 14 patients with PD were analyzed to calculate the beta band power for each contact. neuroimaging reconstruction obtained through brainlab elements planning software detected contacts localized within the STN. clinical DBS programming contact scheme data were collected after one year from the implant. statistical analysis evaluated the diagnostic performance of LFPs beta band power and neuroimaging data for identification of the contacts selected with clinical programming. we evaluated whether the most effective contacts identified based on the clinical response after one year from implant were also those with the highest level of beta activity and localized within the STN in neuroimaging reconstruction. results: LFPs beta power showed a sensitivity of 67%, a negative predictive value (NPV) of 84%, a diagnostic odds ratio (DOR) of 2.7 in predicting the most effective contacts as evaluated through the clinical response. neuroimaging reconstructions showed a sensitivity of 62%, a NPV of 77%, a DOR of 1.20 for contact effectivity prediction. the combined use of the two methods showed a sensitivity of 87%, a NPV of 87%, a DOR of 2.7 for predicting the clinically more effective contacts. conclusions: the combined use of LFPs beta power and neuroimaging localization and segmentations predict which are the most effective contacts as selected on the basis of clinical programming after one year from implant of DBS. the use of predictors in contact selection could guide clinical programming and reduce time needed for it

Introduction

Introduction : Hommage à Alexandre Amprimo

Introduction

Introduction : Hommage à Alexandre Amprimo

« Le souvenir n’est qu’une maison que l’on porte dans la voix » (Alexandre Amprimoz, Bouquet de signes)

Depuis déjà plusieurs années, nous remarquons au Canada la présence d’une littérature unique en son genre, celle des auteurs italo-canadiens. En français, en anglais ou en italien, cette littérature s’est déjà frayé un chemin sûr vers une reconnaissance incontestée au niveau national aussi bien qu’international. Des auteurs tels que Fulvio Caccia, Antonio d’Alfonso, Marco Micone, Carole David-Fioramore, Bianca Zagolin et Alexandre Amprimoz, sont à considérer parmi les lauréats italo-canadiens, porte-parole d’une génération d’érudits cosmopolites et polyglottes. L’œuvre d’Alexandre Amprimoz est, à cet égard, un exemplum des plus marquants d’une littérature multiple et plurielle

« Le souvenir n’est qu’une maison que l’on porte dans la voix » (Alexandre Amprimoz, Bouquet de signes)

Depuis déjà plusieurs années, nous remarquons au Canada la présence d’une littérature unique en son genre, celle des auteurs italo-canadiens. En français, en anglais ou en italien, cette littérature s’est déjà frayé un chemin sûr vers une reconnaissance incontestée au niveau national aussi bien qu’international. Des auteurs tels que Fulvio Caccia, Antonio d’Alfonso, Marco Micone, Carole David-Fioramore, Bianca Zagolin et Alexandre Amprimoz, sont à considérer parmi les lauréats italo-canadiens, porte-parole d’une génération d’érudits cosmopolites et polyglottes. L’œuvre d’Alexandre Amprimoz est, à cet égard, un exemplum des plus marquants d’une littérature multiple et plurielle

Translingualism and Poetry

This chapter investigates how translingualism manifests in poetry. The first two sections are introductory, and they explore, respectively, the specific status of poetry as a genre within the translingual discourse and the distinctive relationship that binds poets and their languages. The ensuing three sections are dedicated to the analysis of exemplary texts and to let emerge relationality, subversion, and transformation as fundamental qualities of translingual poetry. For reasons of scope, the analysis is limited to three main contexts: the italophone, the francophone, and the anglophone. The trajectories that the chapters foreground, however, are deeply rooted in the translingual poetry practice, and as such, may provide an important point of departure for future desirable analyses in other contexts