Weak radiative corrections to the Drell-Yan process for large invariant mass of a dilepton pair

The weak radiative corrections to the Drell-Yan process above the Z-peak have been studied. The compact asymptotic expression for the two heavy boson exchange - one of the significant contributions to the investigated process - has been obtained, the results expand in the powers of the Sudakov electroweak logarithms. At the quark level we compare the weak radiative corrections to the total cross section and forward-backward asymmetry with the existing results and achieve a rather good coincidence at \sqrt{s}>= 0.5 TeV. The numerical analysis has been performed in the high energy region corresponding to the future experiments at the CERN Large Hadron Collider (LHC). To simulate the detector acceptance we used the standard CMS detector cuts. It was shown that double Sudakov logarithms of the WW boxes are the dominant contributions in hadronic cross section. The considered radiative corrections are significant at high dilepton mass M and change the dilepton mass distribution up to ~+3(-12)% at the LHC energies and M=1(5) TeV.Comment: Changed content; 13 pp, 4 fig, 1 tabl

Radiative Corrections to Polarized Inelastic Scattering in Coincidence

The coplete analysis of the model-independent leading radiative corrections to cross-section and polarization observables in semi-inclusive deep-inelastic electron-nucleus scattering with detection of a proton and scattered electron in coincidence has been performed. The basis of the calculations consists of the Drell-Yan like representation in electrodynamics for both spin-independent and spin-dependent parts of the cross-section in terms of the electron structure functions. The applications to the polarization transfer effect from longitudinally polarized electron beam to detected proton as well as to scattering by the polarized target are considered.Comment: 18p, to be published in JET

Inverse bremsstrahlung contributions to Drell-Yan like processes

The contribution of the sub-process $\gamma q \to q' l_1\bar{l}_2$ in hadron-hadron interactions is considered. It is a part of one-loop electroweak radiative corrections for the Drell-Yan production of lepton pairs at hadron colliders. It is shown that this contribution should be taken into account aiming at the 1% accuracy of the Drell-Yan process theoretical description. Both the neutral and charged current cases are evaluated. Numerical results are presented for typical conditions of LHC experiments.Comment: 11 pages, 8 figure

QED Radiative Corrections in Processes of Exclusive Pion Electroproduction

Formalism for radiative correction (RC) calculation in exclusive pion electroproduction on the proton is presented. A FORTRAN code EXCLURAD is developed for the RC procedure. The numerical analysis is done in the kinematics of current Jefferson Lab experiments.Comment: 13 pages, 9 figures; requires RevTeX

Atom-optics hologram in the time domain

The temporal evolution of an atomic wave packet interacting with object and reference electromagnetic waves is investigated beyond the weak perturbation of the initial state. It is shown that the diffraction of an ultracold atomic beam by the inhomogeneous laser field can be interpreted as if the beam passes through a three-dimensional hologram, whose thickness is proportional to the interaction time. It is found that the diffraction efficiency of such a hologram may reach 100% and is determined by the duration of laser pulses. On this basis a method for reconstruction of the object image with matter waves is offered.Comment: RevTeX, 13 pages, 8 figures; minor grammatical change

Atom holography

We study the conditions under which atomic condensates can be used as a recording media and then suggest a reading scheme which allows to reconstruct an object with atomic reading beam. We show that good recording can be achieved for flat condensate profiles and for negative detunings between atomic Bohr frequency and optical field frequency. The resolution of recording dramatically depends on the relation between the healing length of the condensate and the spatial frequency contents of the optical fields involved.Comment: 8 pages, 5 figures, Late

DIRAC - Distributed Infrastructure with Remote Agent Control

This paper describes DIRAC, the LHCb Monte Carlo production system. DIRAC has a client/server architecture based on: Compute elements distributed among the collaborating institutes; Databases for production management, bookkeeping (the metadata catalogue) and software configuration; Monitoring and cataloguing services for updating and accessing the databases. Locally installed software agents implemented in Python monitor the local batch queue, interrogate the production database for any outstanding production requests using the XML-RPC protocol and initiate the job submission. The agent checks and, if necessary, installs any required software automatically. After the job has processed the events, the agent transfers the output data and updates the metadata catalogue. DIRAC has been successfully installed at 18 collaborating institutes, including the DataGRID, and has been used in recent Physics Data Challenges. In the near to medium term future we must use a mixed environment with different types of grid middleware or no middleware. We describe how this flexibility has been achieved and how ubiquitously available grid middleware would improve DIRAC.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 8 pages, Word, 5 figures. PSN TUAT00

ERK inhibitor LY3214996-based treatment strategies for RAS-driven lung cancer

RAS gene mutations are the most frequent oncogenic event in lung cancer. They activate multiple RAS-centric signaling networks among them the MAPK, PI3K and RB pathways. Within the MAPK pathway ERK1/2 proteins exert a bottleneck function for transmitting mitogenic signals and activating cytoplasmic and nuclear targets. In view of disappointing anti-tumor activity and toxicity of continuously applied MEK inhibitors in patients with KRAS mutant lung cancer, research has recently focused on ERK1/2 proteins as therapeutic targets and on ERK inhibitors for their ability to prevent bypass and feedback pathway activation. Here we show that intermittent application of the novel and selective ATP-competitive ERK1/2 inhibitor LY3214996 exerts single-agent activity in patient-derived xenograft (PDX) models of RAS mutant lung cancer. Combination treatments were well tolerated and resulted in synergistic (ERKi plus PI3K/mTORi LY3023414) and additive (ERKi plus CDK4/6i abemaciclib) tumor growth inhibition in PDX models. Future clinical trials are required to investigate if intermittent ERK inhibitor-based treatment schedules can overcome toxicities observed with continuous MEK inhibition and - equally important - to identify biomarkers for patient stratification