Evaluation of pharmacological correction of L-NAME-induced endothelial dysfunction, platelet aggregation and venous tone with diosmin detralex 1000 mg

Chronic venous diseases are one of the urgent problems of modern medicine. Recent studies have shown high significance of endothelial dysfunction (ED) and oxidative stress in their pathogenesis. For the correction of the occurring changes, drugs of the flavonoid group, particularly diosmin and hesperidin, are currently use

Influence of the drug Detralex on calcium ion-dependent smooth muscle contractility, function of an endothelium and aggregation of thrombocytes in the conditions of experimental modeling of endothelial dysfunction

A venotonic effect was investigated after week administration of drug inside on model of the endoteliumdependent smooth muscle response to increased calcium ion isolated portal vein of rats. In model of endothelial dysfunction rising of sensitivity to the contractile response to Сa2+ the isolated segment of a portal vein after use of the drug Detralex of 500 mg/kg per day, and also elongation of AT and decrease of coefficient of endothelial dysfunction on a background the course reception of the investigated preparatio

Lexical interaction of the modern Greek language with Germanic and Romance languages (with reference to the vocabulary of English, French and modern Greek languages)

The article deals with the issues of lexical interaction of the modern Greek language with Germanic and Romance languages (represented by English and French). There were singled out two areas in which this lexical interaction is rather significant: the vocabulary related to food and drinks and the vocabulary used to designate objects and concepts of clothing, shoes, haberdashery and perfumer

Cognitive conceptualization and categorization of time definition in english, french and russian linguistics

The article is devoted to the description of linguocognitive categorization and conceptualization of time by the material of English, French and Russian languages. The process of categorization is aimed at combining similar or identical units into larger categories, and the process of conceptualization is aimed at highlighting the minimum meaningful units of human experience. The multilevel structure of the concept of TIME, due to the complementary nature of the analyzed category, is also considere

Myocardial strain parameters and autonomic balance in various variants of the postinfarction course in patients receiving high-dose atorvastatin therapy

Aim. To study parameters of left ventricular (LV) strain and heart rate variability (HRV) in patients with ST-segment elevation myocardial infarction (STEMI) in various variants of postinfarction receiving high-dose atorvastatin therapy.Material and methods. The study included 96 patients with STEMI. All patients underwent two-dimensional speckle tracking echocardiography and 24-hour electrocardiographic monitoring with HRV analysis. The included individuals were divided into groups without pathological LV remodeling (R (-), n=57) and with pathological post-infarction LV remodeling (R (+), n=39), the criterion for which was an increase in end-diastolic and/or end-systolic volume >20% and >15%, respectively. Further, depending on the achievement of target low-density lipoprotein cholesterol (LDL-C) (1,5 mmol/l and/or a decrease of more than 50%), the following subgroups were identified: 17 (43,6%) people, who reached target LDL-C levels (group 1), 22 (56,4%) patients, who did not reach target LDL-C levels (group 2). Similar subgroups were identified in the R (-) group as follows: 28 (49,1%) people, who reached target LDL-C levels (group 3) and 29 (50,9%) people, who did not reach target LDL-C levels (group 4).Results. Starting from the 12th week of follow-up, worsening of global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain (p<0,01) was registered in group 2. In group 1, worsening of these parameters was registered only by the 48th week (p<0,01). In group 3, an increase in GLS was revealed by the 48th week (p=0,001), GCS and GRS — by the 12th week (p<0,05). In group 4, favorable changes were observed only in GLS and GCS by the 48th week (p<0,01). A significant change in HRV parameters was observed in group 3. By the 48th week, there was an increase in temporal indicators (SDNN, SDNNi, SDANN, RMSSD, pNN50) (p<0,0001) and total spectrum power (p=0,0001) due to an increase in all frequency indicators (p<0,001), while the index of autonomic balance L/H decreased by 33% (p=0,002). In group 4, only SDNN, SDANN and pNN50 (p<0,05), as well as the total spectrum power (p=0,001) increased, but no change in frequencies. According to intergroup analysis in the acute period of STEMI, group 4 patients had higher HRV than in group 3 (p<0,05).Conclusion. High-dose atorvastatin therapy improves LV strain characteristics and autonomic balance during the rehabilitation period after STEMI

Characteristics of the Plasma Disturbance Excited at Altitudes of 450–500 km During the “Sura” Facility Operation

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. We discuss the results of measuring characteristics of the artificial plasma disturbances excited at altitudes of 450–500 km with the ionospheric F2 layer modified by high-power HF radio waves from the Sura facility. It is found that at these altitudes there are plasma temperature and density variations in the HF-perturbed magnetic flux tube. No ducts with increased plasma density that were previously observed at altitudes of about 660 km were detected. The results of the studies are compared with the data from the DEMETER satellite and the results of radiotomographic measurements. It is noted that the field-aligned currents induced in a perturbed ionosphere during the Sura operation were detected for the first time using SWARM satellites