23 research outputs found
Event-driven management algorithm of an Engineering documents circulation system
Development methodology of an engineering documents circulation system in the design company is reviewed. Discrete event-driven automatic models using description algorithms of project management is offered. Petri net use for dynamic design of projects is offered
ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ 8-ΠΎΠΊΡΠΎ-2'-Π΄Π΅Π·ΠΎΠΊΡΠΈΠ³ΡΠ°Π½ΠΎΠ·ΠΈΠ½Π° ΠΊ 2'-Π΄Π΅Π·ΠΎΠΊΡΠΈΠ³ΡΠ°Π½ΠΎΠ·ΠΈΠ½Ρ Π² ΠΠΠ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΎΠ±ΡΠ°ΡΠ΅Π½Π½ΠΎ-ΡΠ°Π·ΠΎΠ²ΠΎΠΉ ΠΠΠΠ₯ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π°ΠΌΠΏΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ
The article presents an optimized method for the determination of the ratio of 8-oxo-2'-deoxyguanosine (formed in DNA due to the action of active forms of oxygen) to 2'-deoxyguanosine. The ratio was determined by reverse phase HPLC combined with amperometric detection. It was shown that the ratio increases upon oxidative stress caused by the action of large doses of ascorbic acid in samples of DNA isolated from the liver of experimental rats.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ 8-ΠΎΠΊΡΠΎ-2'-Π΄Π΅Π·ΠΎΠΊΡΠΈΠ³ΡΠ°Π½ΠΎΠ·ΠΈΠ½Π°, ΠΎΠ±ΡΠ°Π·ΡΡΡΠ΅Π³ΠΎΡΡ Π² ΠΠΠ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΡΠΌ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°, ΠΊ 2'-Π΄Π΅Π·ΠΎΠΊΡΠΈΠ³ΡΠ°Π½ΠΎΠ·ΠΈΠ½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΎΠ±ΡΠ°ΡΠ΅Π½Π½ΠΎ-ΡΠ°Π·ΠΎΠ²ΠΎΠΉ ΠΠΠΠ₯ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π°ΠΌΠΏΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ³ΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΏΡΠΈ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ ΡΡΡΠ΅ΡΡΠ΅, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ Π±ΠΎΠ»ΡΡΠΈΡ
Π΄ΠΎΠ· Π°ΡΠΊΠΎΡΠ±ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ, Π² ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
ΠΠΠ, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
ΠΈΠ· ΠΏΠ΅ΡΠ΅Π½ΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΊΡΡΡ
ΠΠ½Π°Π»ΠΈΠ· ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ 8-ΠΎΠΊΡΠΎ-2'-Π΄Π΅Π·ΠΎΠΊΡΠΈΠ³ΡΠ°Π½ΠΎΠ·ΠΈΠ½Π° Π² ΠΠΠ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΎΠ·Π³Π° ΠΊΡΡΡ ΠΏΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ Π·Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠ½Π°
The protective effect of cortexin was investigated with the use of acoustic stress hemorrhagic stroke model. A significant decrease of 8-oxo-2'-deoxyguanosine to 2'-deoxyguanosine ratio in the DNA molecule was shown using brain slices of cortexin treated Krushinsky-Molodkina rats.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π·Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠ½ Π½Π° ΠΌΠΎΠ·Π³ ΠΊΡΡΡ Π»ΠΈΠ½ΠΈΠΈ ΠΡΡΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ-ΠΠΎΠ»ΠΎΠ΄ΠΊΠΈΠ½ΠΎΠΉ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π³Π΅ΠΌΠΎΡΡΠ°Π³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ°, Π²ΡΠ·Π²Π°Π½-Π½ΠΎΠ³ΠΎ Π°ΠΊΡΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΡΠ΅ΡΡΠΎΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ 8-ΠΎΠΊΡΠΎ-2'-Π΄Π΅Π·ΠΎΠΊΡΠΈ-Π³ΡΠ°Π½ΠΎΠ·ΠΈΠ½Π° ΠΊ 2'-Π΄Π΅Π·ΠΎΠΊΡΠΈΠ³ΡΠ°Π½ΠΎΠ·ΠΈΠ½Ρ Π² ΠΠΠ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΎΠ·Π³Π° ΠΊΡΡΡ ΠΏΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠ½Π°
MATHEMATICAL PROGRAMS MODERNIZATION BASED ON RUSSIAN AND INTERNATIONAL STANDARDS
Russian education standards have come a long way from being extremely detailed and regulating the content of education programs at all levels to the current state when there is a great freedom for universities in defining its education programs. The downside of that freedom is too general formulations of these competences and absence of framework requirements for the scope and content of individual parts of educational programs for the various types of training. This raises the problem of preserving the unity of educational space in Russia and the traditionally high level of teaching mathematics in Russian universities. Russian scientific and educational community together with industry and business are currently looking for the ways to solve this problem.
In the paper, the experience of the modernization educational programs in the field of information and communication technologies is considered. The methodology of creation of valid assessment tools funds to check formation of competences is presented. The presented results are based on the methodology of international and Russian scientific and methodological projects.
Currently obtained results of approbation of the methodology showed that the chosen modernization methods are an effective tool for solving the designated math-related problems in engineering education in Russian universities and, consequently, students will start to correspond more adequately to the labor market needs
The experience of updating the educational standards of higher education in the field of ICT
The article describes the experience of Russian universities in integrating professional and educational standards in the design of higher education educational programs in the field of information and communication technologies.
A number of aspects of the current versions of FSES have been identified, which pose a problem for interfacing with professional standards in the development of basic educational programs.
Methodical recommendations on the actualization of the FSES and the selection of professional standards developed by the leading Russian universities as a result of the implementation of international and domestic projects are presented. The analysis of the conformity of generalized labor functions and their components from professional standards to general professional and professional competences from FSES under the bachelor's program 02.03.02 Fundamental informatics and information technologies is carred out
Lightweight refractories of self-compacting mixtures. A rapid method of chamotte-free ultraporous refractories
Synthesis and Fungicidal Activity of Substituted N-(Alkoxy)-1-(3-pyridinyl)methanonimines
Synthesis and Fungicidal Activity of Substituted (E)-3-Phenyl-1-(pyridin-3-yl)prop-2-en-1-one (E,Z)-O-Alkyl- and O-Benzyloximes
8-Oxo-7,8-dihydro-2β²-deoxyguanosine values measured in brain DNA of rats upon investigating cortexin protective action
The protective effect of cortexin was investigated with the use of acoustic stress hemorrhagic stroke model. A significant decrease of 8-oxo-2'-deoxyguanosine to 2'-deoxyguanosine ratio in the DNA molecule was shown using brain slices of cortexin treated Krushinsky-Molodkina rats