23 research outputs found
ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π»ΠΈΠΌΡΠ°Π΄Π΅Π½ΠΎΠΏΠ°ΡΠΈΠΈ ΡΡΠ΅Π΄ΠΎΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΈ Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΠ°ΡΠΎΠ·Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ Π»Π΅Π³ΠΊΠΈΡ
The purpose of this study was to determine detection rate and clinical and morphological characteristics of mediastinal lymphadenopathy (ML) in patients with respiratory system sarcoidosis (RSS), disseminated pulmonary tuberculosis (DPT) and exogenic allergic alveolitis (EAA).Materials and Methods. Patients (n = 278) with established diagnosis RSS, DPT, EAA were investigated. The cumulative index parameters were determined, hematology test, assessments of pulmonary function, diffuse lung capacity, diffusion coefficient were performed in all patients. Computed tomography of chest organs and morphologic examination of mediastinal lymph node (LN) biopsy were performed.Results. Subjects with newly diagnosed (n = 72) and recurrent (n = 104) disease were observed among patients with RSS (n = 176). ML was observed in 95% of cases, involved bronchopulmonary, bifurcation, paratracheal and paraaortal groups; dimensions of intrathoracic LN (ITLN) were 20.0 Β± 1.9 mm. Epitheliocellular granulomas (EG) without necrosis, not fusing with each other, were established morphologically; they were determined in recurrent disease course in association with background fibrosis. In patients with DPT (n = 41), subacute (n = 28) and chronic (n = 13) disease course was noted. With subacute course of DPT in 28.6% of cases, ML of paratracheal and bifurcation groups (dimensions of ITLN β 13.1 Β± 0.3 mm) was observed, with chronic course β the enlargement of paratracheal and bronchopulmonary LN (7.7% of cases). EG with necrosis and tendency to fusion was verified histologically; inflammatory process involved LN capsule and could be spread to fatty tissue. In patients with EAA (n = 76), acute (n = 10), subacute (n = 38) and chronic (n = 28) disease courses were observed. With acute EAA course, hyperplasia of ITLN of bifurcation and tracheo-bronchial groups up to 13.5 Β± 0.6 mm was observed in 20% of cases. Follicular hyperplasia with widening and edema of hermintative centers was observed at morphological investigation. With subacute EAA course, increased ITLN in bifurcation and broncho-pulmonary groups up to 13.6 Β± 0.6 mm were observed in 46% of cases. Formation of histiocytic-macrophagal granulomas without epithelioid cells and deposit precipitation in the plasma cell aggregation areas was found at morphological evaluation. With chronic EAA, ML in broncho-pulmonary and paratracheal groups was detected in 17.8% of cases (enlargement of LN up to 11 Β± 0.9 mm). The formation of diffuse and focal fibrosis and hyalinosis was noted morphologically.Conclusion. ML is observed in all granulomatous pulmonary diseases studied, however its rate and severity, composition of involved ITLN groups and character of morphological changes is different which is possible to use in diagnostics.Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ°ΡΡΠΎΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π»ΠΈΠΌΡΠ°Π΄Π΅Π½ΠΎΠΏΠ°ΡΠΈΠΈ ΡΡΠ΅Π΄ΠΎΡΡΠ΅Π½ΠΈΡ (ΠΠ‘) Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΡΠΊΠΎΠΈΠ΄ΠΎΠ·ΠΎΠΌ ΠΎΡΠ³Π°Π½ΠΎΠ² Π΄ΡΡ
Π°Π½ΠΈΡ (Π‘ΠΠ), Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·ΠΎΠΌ Π»Π΅Π³ΠΊΠΈΡ
(ΠΠ’Π) ΠΈ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΠΌ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π°Π»ΡΠ²Π΅ΠΎΠ»ΠΈΡΠΎΠΌ (ΠΠΠ).ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ (n = 278) Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΡΠΌΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π°ΠΌΠΈ Π‘ΠΠ, ΠΠ’Π ΠΈ ΠΠΠ. Π£ Π²ΡΠ΅Ρ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΊΡΠΌΡΠ»ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠ½Π΄Π΅ΠΊΡΠ°, ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΡΠΎΠ²ΠΈ, ΡΡΠ½ΠΊΡΠΈΠΈ Π²Π½Π΅ΡΠ½Π΅Π³ΠΎ Π΄ΡΡ
Π°Π½ΠΈΡ, Π΄ΠΈΡΡΡΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π»Π΅Π³ΠΊΠΈΡ
, ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠ° Π΄ΠΈΡΡΡΠ·ΠΈΠΈ. ΠΡΠΏΠΎΠ»Π½ΡΠ»ΠΈΡΡ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ ΠΎΡΠ³Π°Π½ΠΎΠ² Π³ΡΡΠ΄Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΠΈΠΎΠΏΡΠΈΠΈ Π»ΠΈΠΌΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ·Π»ΠΎΠ² (ΠΠ£) ΡΡΠ΅Π΄ΠΎΡΡΠ΅Π½ΠΈΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π‘ΡΠ΅Π΄ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘ΠΠ (n = 176) Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ Π»ΠΈΡΠ° Ρ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΡΠΌ (n = 72) ΠΈ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΡΡΡΠΈΠΌ (n = 104) Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ. ΠΠ‘ Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ Π² 95 % ΡΠ»ΡΡΠ°Π΅Π², Π·Π°ΡΡΠ°Π³ΠΈΠ²Π°Π»Π° Π±ΡΠΎΠ½Ρ
ΠΎΠΏΡΠ»ΡΠΌΠΎΠ½Π°Π»ΡΠ½ΡΠ΅, Π±ΠΈΡΡΡΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅, ΠΏΠ°ΡΠ°ΡΡΠ°Ρ
Π΅Π°Π»ΡΠ½ΡΠ΅ ΠΈ ΠΏΠ°ΡΠ°Π°ΠΎΡΡΠ°Π»ΡΠ½ΡΠ΅ Π³ΡΡΠΏΠΏΡ; ΡΠ°Π·ΠΌΠ΅ΡΡ Π²Π½ΡΡΡΠΈΠ³ΡΡΠ΄Π½ΡΡ
ΠΠ£ (ΠΠΠΠ£) ΡΠΎΡΡΠ°Π²Π»ΡΠ»ΠΈ 20,0 Β± 1,9 ΠΌΠΌ. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΡΠΏΠΈΡΠ΅Π»ΠΈΠΎΠΈΠ΄Π½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΡ (ΠΠ) Π±Π΅Π· Π½Π΅ΠΊΡΠΎΠ·Π°, Π½Π΅ ΡΠ»ΠΈΠ²Π°ΡΡΠΈΠ΅ΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΎΠ±ΠΎΠΉ, ΠΏΡΠΈ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΡΡΡΠ΅ΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈΡΡ Π½Π° ΡΠΎΠ½Π΅ ΡΠΈΠ±ΡΠΎΠ·Π°. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ’Π (n = 41) ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ ΠΏΠΎΠ΄ΠΎΡΡΡΠΎΠ΅ (n = 28) ΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ (n = 13) ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠΈ ΠΏΠΎΠ΄ΠΎΡΡΡΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΠ’Π Π² 28,6 % ΡΠ»ΡΡΠ°Π΅Π² Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ ΠΠ‘ ΠΏΠ°ΡΠ°ΡΡΠ°Ρ
Π΅Π°Π»ΡΠ½ΠΎΠΉ ΠΈ Π±ΠΈΡΡΡΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π³ΡΡΠΏΠΏ (ΡΠ°Π·ΠΌΠ΅ΡΡ ΠΠΠΠ£ β 13,1 Β± 0,3 ΠΌΠΌ), ΠΏΡΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ β ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠ°ΡΡΠ°Ρ
Π΅Π°Π»ΡΠ½ΡΡ
ΠΈ Π±ΡΠΎΠ½Ρ
ΠΎΠΏΡΠ»ΡΠΌΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΠ£ (7,7 % ΡΠ»ΡΡΠ°Π΅Π²). ΠΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π° ΠΠ Ρ Π½Π΅ΠΊΡΠΎΠ·ΠΎΠΌ ΠΈ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠ΅ΠΉ ΠΊ ΡΠ»ΠΈΡΠ½ΠΈΡ; Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΏΡΠΎΡΠ΅ΡΡ Π·Π°ΡΡΠ°Π³ΠΈΠ²Π°Π» ΠΊΠ°ΠΏΡΡΠ»Ρ ΠΠ£ ΠΈ ΠΌΠΎΠ³ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΈΡΡ Π½Π° ΠΆΠΈΡΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΡΠ°ΡΠΊΡ. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠΠ (n = 76) ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΎΡΡΡΠΎΠ΅ (n = 10), ΠΏΠΎΠ΄ΠΎΡΡΡΠΎΠ΅ (n = 38) ΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ (n = 28) ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠΈ ΠΎΡΡΡΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΠΠ Π² 20 % ΡΠ»ΡΡΠ°Π΅Π² Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ Π΄ΠΎ 13,5 Β± 0,6 ΠΌΠΌ ΠΠΠΠ£ Π±ΠΈΡΡΡΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈ ΡΡΠ°Ρ
Π΅ΠΎΠ±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏ. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π²ΡΡΠ²Π»ΡΠ»Π°ΡΡ ΡΠΎΠ»Π»ΠΈΠΊΡΠ»ΡΡΠ½Π°Ρ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ Ρ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈ ΠΎΡΠ΅ΠΊΠΎΠΌ Π³Π΅ΡΠΌΠΈΠ½ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΡΠ΅Π½ΡΡΠΎΠ². ΠΡΠΈ ΠΏΠΎΠ΄ΠΎΡΡΡΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΠΠ Π² 46 % ΡΠ»ΡΡΠ°Π΅Π² ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ Π΄ΠΎ 13,6 Β± 0,6 ΠΌΠΌ ΠΠΠΠ£ Π±ΠΈΡΡΡΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈ Π±ΡΠΎΠ½Ρ
ΠΎΠΏΡΠ»ΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏ. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π²ΡΡΠ²Π»ΡΠ»ΠΎΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠ°ΡΠ½ΠΎ-ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°Π»ΡΠ½ΡΡ
Π³ΡΠ°Π½ΡΠ»Π΅ΠΌ Π±Π΅Π· ΡΠΏΠΈΡΠ΅Π»ΠΈΠΎΠΈΠ΄Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΠΎΡΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π΄Π΅ΠΏΠΎΠ·ΠΈΡΠΎΠ² Π² Π·ΠΎΠ½Π°Ρ
ΡΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΡΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΠΠ ΠΠ‘ Π±ΡΠΎΠ½Ρ
ΠΎΠΏΡΠ»ΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΈ ΠΏΠ°ΡΠ°ΡΡΠ°Ρ
Π΅Π°Π»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏ Π²ΡΡΠ²Π»Π΅Π½Π° Π² 17,8 % ΡΠ»ΡΡΠ°Π΅Π² (ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΠ£ Π΄ΠΎ 11 Β± 0,9 ΠΌΠΌ). ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΡΡΡΠ·Π½ΠΎΠ³ΠΎ ΠΈ ΠΎΡΠ°Π³ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΈΠ±ΡΠΎΠ·Π° ΠΈ Π³ΠΈΠ°Π»ΠΈΠ½ΠΎΠ·Π°.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ‘ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΏΡΠΈ Π²ΡΠ΅Ρ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΠ°ΡΠΎΠ·Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
Π»Π΅Π³ΠΊΠΈΡ
, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΠ°ΡΡΠΎΡΠ° ΠΈ ΡΡΠ΅ΠΏΠ΅Π½Ρ Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ, ΡΠΎΡΡΠ°Π² Π²ΠΎΠ²Π»Π΅ΠΊΠ°Π΅ΠΌΡΡ
Π³ΡΡΠΏΠΏ ΠΠΠΠ£ ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΠ°Π·Π»ΠΈΡΠ΅Π½, ΡΡΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅
ΠΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°Π½ΡΠΈΠ΄ΠΈΡΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ΅Π΄ΡΡΠ² ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°Ρ Π°ΡΠ½ΠΎΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠ΅ 2 ΡΠΈΠΏΠ° = Periodontitis-protective effecr of anti-dysbiotic means at experimental diabetes mellitus type 2
Stupak E. P., Skidan K. V., Skidan M. I., Dem'yanenko S. A. ΠΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°Π½ΡΠΈΠ΄ΠΈΡΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠ΅ 2 ΡΠΈΠΏΠ° = Periodontitis-protective effecr of anti-dysbiotic means at experimental diabetesΒ mellitus type 2. Journal of Education, Health and Sport. 2015;5(12):588-597. eISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.44264
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A588-597
http://pbn.nauka.gov.pl/works/687233
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011β2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive
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The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport (null) 2391-8306 7
Β© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.12.2015. Revised 15.12.2015. Accepted: 29.12.2015.
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Π£ΠΠ 616.731-07.23.008
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ΠΠΠ ΠΠΠΠΠ’ΠΠΠ ΠΠ’ΠΠΠ’ΠΠ ΠΠΠ ΠΠΠΠ‘Π’ΠΠΠ ΠΠΠ’ΠΠΠΠ‘ΠΠΠΠ’ΠΠ§ΠΠ‘ΠΠΠ₯ Π‘Π ΠΠΠ‘Π’Π ΠΠ Π ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’ΠΠΠ¬ΠΠΠ Π‘ΠΠ₯ΠΠ ΠΠΠ ΠΠΠΠΠΠ’Π 2 Π’ΠΠΠ
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PERIODONTITIS-PROTECTIVE EFFECR OF ANTI-DYSBIOTIC MEANS AT EXPERIMENTAL DIABETESΒ MELLITUS TYPE 2
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Π. Π. Π‘ΡΡΠΏΠ°ΠΊ1, Π. Π. Π‘ΠΊΠΈΠ΄Π°Π½2, Π. Π. Π‘ΠΊΠΈΠ΄Π°Π½2, Π‘. Π. ΠΠ΅ΠΌΡΡΠ½Π΅Π½ΠΊΠΎ3
E. P. Stupak1, K. V. Skidan2, M. I. Skidan2, S. A. Dem'yanenko3
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1ΠΠΠ£Π£ Β«Π£ΠΊΡΠ°ΠΈΠ½ΡΠΊΠ°Ρ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠ°Ρ ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΒ», Π³. ΠΠΎΠ»ΡΠ°Π²Π°
2Π₯Π°ΡΡΠΊΠΎΠ²ΡΠΊΠΈΠΉ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠΉ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅Ρ
3ΠΡΡΠΌΡΠΊΠΈΠΉ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠΉ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅Ρ
ΠΈΠΌ. Π‘. Π. ΠΠ΅ΠΎΡΠ³ΠΈΠ΅Π²ΡΠΊΠΎΠ³ΠΎ, Π³. Π‘ΠΈΠΌΡΠ΅ΡΠΎΠΏΠΎΠ»Ρ
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1HSEI Β«Ukrainian medical Stomatological AcademyΒ», Poltava
2Kharkiv national medical university, Kharkiv
3Crimean State Medical University named after S.I.Georgievskij, Simferopol
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Abstract
Aim: To determine the therapeutic and preventive effect of oral gels with anti-dysbiotic means (ADM) on periodont at type 2 diabetes mellitus (DMT2).
Materials and Methods: Diabetes in rats was induced by an intra-muscular administration of protamine sulfate for 10 days. As ADM there were used lysozyme, quercetin, flour, mucosin and flour from vine leaves, which were applied in form of gels on the oral mucosa of rats for 2 weeks. In the gums' homogenates there were determined the activities of urease, lysozyme, elastase, catalase and the MDA content. The degree of dysbiosis by Levitsky was calculated as the ratio of the relative activities of urease and lysozyme. The antioxidant-prooxidant index API was calculated as the ratio of the catalase activity and the MDA content.
Results: The urease activity, the degree of dysbiosis, the elastase activity and the MDA content were increased while the lysozyme activity and the index API were reduced in rats with diabetes type 2 in the periodont. Applied gels containing ADM showed therapeutic and preventive effects.
Conclusion: At diabetes type 2 in the periodont of rats there were developing dysbiosis and inflammation. The application of oral gels with ADM provided a therapeutic and preventive treatment.
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Keywords: diabetes type 2, periodont, dysbiosis, inflammation, anti-dysbiotic means, oral gels.
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Π Π΅Π·ΡΠΌΠ΅
ΠΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°Ρ
Π°ΡΠ½ΠΎΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠ΅ 2 ΡΠΈΠΏΠ° Π² Π΄Π΅ΡΠ½Π΅ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ Π΄ΠΈΡΠ±ΠΈΠΎΠ· ΠΈ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅. ΠΡΠ°Π»ΡΠ½ΡΠ΅ Π³Π΅Π»ΠΈ Ρ Π°Π½ΡΠΈΠ΄ΠΈΡΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΡΠ΅Π΄ΡΡΠ²Π°ΠΌΠΈ (Π»ΠΈΠ·ΠΎΡΠΈΠΌ, ΠΊΠ²Π΅ΡΡΠ΅ΡΠΈΠ½, ΠΌΡΠΊΠΎΠ·ΠΈΠ½ ΠΈ ΠΌΡΠΊΠ° ΠΈΠ· Π²ΠΈΠ½ΠΎΠ³ΡΠ°Π΄Π½ΡΡ
Π»ΠΈΡΡΡΠ΅Π²) ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ.
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ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΡΠ°Ρ
Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ 2 ΡΠΈΠΏΠ°, ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½Ρ, Π΄ΠΈΡΠ±ΠΈΠΎΠ·, Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅, Π°Π½ΡΠΈΠ΄ΠΈΡΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ΅Π΄ΡΡΠ²Π°, ΠΎΡΠ°Π»ΡΠ½ΡΠ΅ Π³Π΅Π»ΠΈ