Vitamin D3 (Cholecalciferol) and Pelvic Pain Caused by Ovarian Endometriosis

Статья посвящена изучению взаимосвязи концентрации витамина D с наличием и интенсивностью тазовой боли у женщин, страдающих эндометриозом яичников. Цель исследования: установить взаимосвязь уровня витамина D и интенсивности тазовой боли у женщин, страдающих эндометриозом яичников. В исследование были включены 190 женщин репродуктивного возраста с верифицированным диагнозом эндометриоз яичников, в возрасте от 20 до 41 года (средний возраст – 29,1±3,3 года). Для определения интенсивности тазовой боли использовали визуальную аналоговую шкалу (ВАШ). Всем пациенткам (n=190) исходно оценку уровня витамина D проводили путем определения уровня общего 25(ОН)D в сыворотке крови методом масс-спектрометрии, адаптированным к клинической практике, согласно международным стандартам, на тандемном масс-спектрометре AB SCIEX QTRAP 5500.The article studies the relation between vitamin D concentration and the presence and intensity of pelvic pain in women suffering from ovarian endometriosis. The aim of the study is to examine the relation between vitamin D levels and intensity of pelvic pain in women with ovarian endometriosis. Study design: cohort, prospective, non-comparative study. The study included 190 women of reproductive age suffering from ovarian endometriosis (OE), aged 20 to 41 years (mean age 29.1±3.3 years). Visual analogue scale (VAS) was used to determine the intensity of pelvic pain.The evaluation of vitamin D level in all patients (n=190) was initially performed by determining the level of total 25 (OH) D in blood serum by the method of mass spectrometry. Study Results: The average vitamin D level in the study was 23.98±6.82 ng/ml. The average concentration of vitamin D in the blood of the patients with low-intensity pelvic pain was 26.7±5.92 ng/ml, with moderate-intensity – 23.06±of 5.55 ng/ml, with high pain intensity – 19.26±6,01 ng/ml. The content of vitamin D in the blood of the patients in the control group was 28.83±6.15 ng/ml, which met the criteria of insufficiency. Аn inverse correlation between the severity of pain based on VAS and vitamin D in women with endometriosis of the main group was established in the study, it amounted to 0.502 (p<0.001)

Survival strategies in an evolutionary finance model with endogenous asset payoffs

Evolutionary Finance explores financial markets as evolving biological systems. Investors pursuing diverse investment strategies compete for the market capital. Some “survive” and some “become extinct”. A central goal is to identify strategies guaranteeing survival in the market selection process. The problem is analyzed in frameworks combining stochastic dynamic games and evolutionary game theory. Most of the models currently considered in the field assume that asset payoffs are exogenous and depend only on the underlying stochastic process of states of the world. The present work examines a model where the payoffs are endogenous: they depend on the share of total market wealth invested in the asset

FEATURES OF VASCULAR ENDOTHELIAL FUNCTIONING IN HEALTHY PERSONS IN DIFFERENT PERIODS OF SOLAR ACTIVITY

Functional properties of vascular endothe­lium in healthy persons had been studied by probe with in­duced ischemia depending on a solar activity (SA) period during the 23rd solar cycle. The blood viscosity had been es­timated before and after occlusion test. The nascency of an­giospasm in a low SA is accompanied by adaptive increase of a blood flow property, and in a high SA this mechanism is been losing. So, in healthy persons the period of SA deter­mines functional properties of vascular endothelium. 

ENDOTHELIAL DYSFUNCTION AND BLOOD VISCOSITY INPATIENTS WITH UNSTABLE ANGINA IN DIFFERENT PERIODS OF A SOLAR ACTIVITY

The origin of hemorheologic and endothelial defects in patients with unstable angina (comparing with healthy persons) is determined by a solar activity period: the blood viscosity increases in a period of high solar activity in the vessels of small, medium and macro diameters, a local decompensate dysfunction of small vessels endothelium had been fixed (microcirculation area). In the period of a low solar activity there is an increase of a blood viscosity in vessels of all diameters, generalized subcompensated endothelial dysfunction is developed (on the background of the III phase blood clotting activating). In the period of a high solar activity a higher blood viscosity had been fixed, comparing with the period of a low solar activity. 

Correction of disorders in tissue perfusion, blood coagulation and fibrinolysis with Orbita apparatus on terahertz waves of cell metabolites

This article contains information on principle of operation, technical parameters and possible application of Orbita {transliteration from Russian} apparatus for hemodynamic, fibrinolytic and peripheral perfusion disorders treatment. A single exposure to terahertz waves emitted by Orbita apparatus, corresponding to frequencies of molecular absorption and emission spectra of atmospheric oxygen (129.0 GHz), completely cures coagulant and fibrinolytic disorders of animals with acute immobilization stress. A course of treatment with electromagnetic waves corresponding to frequencies of molecular absorption and emission spectra of nitrogen oxide (150.176 – 150.664) leads to normalization of disrupted peripheral tissue perfusion parameters of animal undergoing treatment and stimulates basal and induced output of nitrogen oxide. This leads to decrease in peripheral vascular resistance to microcirculation and increase in blood flow to microvasculature. Experimental data provided in this article serves as a proof of viability of Orbita apparatus for treatment of coagulant, fibrinolytic and tissue perfusion disorders

Treatment Efficacy In Patients with Pelvic Pain Caused By External Genital Endometriosis

Цель – оценить эффективность лечения тазовой боли, обусловленной наружным генитальным эндометриозом в репродуктивном возрасте. Материал и методы. Под наблюдением находилось 65 пациенток репродуктивного возраста с установленным диагнозом наружный генитальный эндометриоз с синдромом хронической тазовой боли различной степени выраженности, средний возраст которых составил в среднем 36±2 года. Пациентки получали терапию антагонистами ГнРг и агонистами ГнРг в течение 12 нед. После лечения пациентки наблюдались 12 мес. Методы исследования: оценка интенсивности болевого синдрома по шкале Бибероглу и Бермана, цифровой рейтинговой шкале, вербальной рейтинговой шкале, анализ побочных эффектов, статистический метод. Результаты. На фоне курса применения антГнРг и аГнРг наблюдалось достоверное уменьшение болевого синдрома. Так, выраженность хронической тазовой боли у пациенток, принимавших антГнРг снизилась в 4,1 раза в группе со слабым болевым синдромом; в 3,7 в группе – с умеренным болевым синдромом и в 1,7 раза в группе – с выраженным болевым синдромом. У пациенток, принимавших аГнРг, болевая симптоматика снизилась в 3,9, в 2,8 и в 1,2 раза в соответствующих группах. Контрольные ультразвуковые показатели эхоструктуры эндометрия не выявили гиперпролиферативных изменений к концу лечения, а также через три, шесть и двенадцать месяцев после отмены препаратов. Выводы. Терапия хронической тазовой боли антГнРг оказалось более эффективной, в сравнении с аГнРг.Objective: to study the efficacy of treatment of endometriosis- associated chronic pelvic pain in patients of the reproductive age. Materials and Methods: 65 patients of reproductive age with the established diagnosis of external genital endometriosis with chronic pelvic pain syndrome of various severity, who had an average age of 36 ± 2 years, were observed. Patients received therapy with gonadotropin-releasing hormone antagonists (antGnRg) and gonadotropin-releasing hormone agonists (aGnRg) for 12 weeks. After the treatment, patients were observed for 12 months. Research methods: evaluation of pain syndrome intensity according to the Biberoglu and Berman scale, the numeric rating scale, the verbal rating scale, the analysis of side effects, the statistical method. Results: During the antGnRg and aGnRg therapy the pain syndrome has significantly decreased. Thus, the severity of chronic pelvic pain in patients taking antGnRg decreased by 4.1 times in the group with mild pelvic pain syndrome, by 3.7 times in the group with moderate pelvic pain syndrome, and by 1.7 times in the group with severe pelvic pain syndrome. In the patients who received aGnRg, the pelvic pain syndrome expressiveness decreased by 3.9, 2.8, and 1.2 times, respectively. The control ultrasound indices of the endometrial echostructure did not reveal hyperproliferative changes at the end of treatment, and also three, six, and twelve months after drug withdrawal. Conclusions: Therapy of chronic pelvic pain with antGnRg proved to be more effective, in comparison with aGnRg