506 research outputs found
Status of Rockwell-ERC high efficiency solar cell programs
Programs aimed at developing large area, high efficiency GaAs heteroface cells for low concentration space applications and high concentration terrestrial applications as well as other programs aimed at developing high efficiency multicolor devices for use in similar applications are described. An additional program aimed at achieving improved power to weight ratio by parting thin film solar cells from their growth substrates prior to their incorporation into an array assembly is also described. There is potential for multiple reuse of the substrates which could lead to reduced costs for such devices. Highlights of these programs and their interrelated contributions toward the goals of reducing specific weight, volume and cost of photovoltaic space power systems are discussed. Overall goals are summarized and current programs and their funding sources are listed
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Dynamic interpersonal therapy for moderate to severe depression: A pilot randomized controlled and feasibility trial
Background: Improving Access to Psychological Therapies (IAPT) services treat most patients in England who present to primary care with major depression. Psychodynamic psychotherapy is one of the psychotherapies offered. Dynamic Interpersonal Therapy (DIT) is a psychodynamic and mentalization-based treatment for depression. 16 sessions are delivered over approximately 5 months. Neither DIT's effectiveness relative to low-intensity treatment (LIT), nor the feasibility of randomizing patients to psychodynamic or cognitive-behavioural treatments (CBT) in an IAPT setting has been demonstrated.
Methods: 147 patients were randomized in a 3:2:1 ratio to DIT (n = 73), LIT (control intervention; n = 54) or CBT (n = 20) in four IAPT treatment services in a combined superiority and feasibility design. Patients meeting criteria for major depressive disorder were assessed at baseline, mid-treatment (3 months) and post-treatment (6 months) using the Hamilton Rating Scale for Depression (HRSD-17), Beck Depression Inventory-II (BDI-II) and other self-rated questionnaire measures. Patients receiving DIT were also followed up 6 months post-completion.
Results: The DIT arm showed significantly lower HRSD-17 scores at the 6-month primary end-point compared with LIT (d = 0.70). Significantly more DIT patients (51%) showed clinically significant change on the HRSD-17 compared with LIT (9%). The DIT and CBT arms showed equivalence on most outcomes. Results were similar with the BDI-II. DIT showed benefit across a range of secondary outcomes.ConclusionsDIT delivered in a primary care setting is superior to LIT and can be appropriately compared with CBT in future RCTs
A rationale for rapid staging of patients with aortopulmonary shunts: Increased oscillatory work
In the Interests of clients or commerce? Legal aid, supply, demand, and 'ethical indeterminacy' in criminal defence work
As a professional, a lawyer's first duty is to serve the client's best interests, before simple monetary gain. In criminal defence work, this duty has been questioned in the debate about the causes of growth in legal aid spending: is it driven by lawyers (suppliers) inducing unnecessary demand for their services or are they merely responding to increased demand? Research reported here found clear evidence of a change in the handling of cases in response to new payment structures, though in ways unexpected by the policy's proponents. The paper develops the concept of 'ethical indeterminacy' as a way of understanding how defence lawyers seek to reconcile the interests of commerce and clients. Ethical indeterminacy suggests that where different courses of action could each be said to benefit the client, the lawyer will tend to advise the client to decide in the lawyer's own interests. Ethical indeterminacy is mediated by a range of competing conceptions of 'quality' and 'need'. The paper goes on to question the very distinction between 'supply' and 'demand' in the provision of legal services
Barriers to recruitment when conducting a commissioned randomised controlled trial of medication versus psychological therapy for generalised anxiety disorder: some lessons learned
Background
Poor recruitment is the most common reason for premature discontinuation of randomised controlled trials (RCTs). An RCT of medication versus psychological therapy for generalised anxiety disorder (GAD) was discontinued prematurely by the UK National Institute of Health Research funders because of recruitment failure. In order to inform future research studies, this article explores the reasons for poor recruitment and aspects which could have been improved.
Methods
The trial recruited participants via psychological well-being practitioners (PWPs) employed within local Improving Assess to Psychological Therapies (IAPT) services at four sites in England. For this study, we initially examined the recruitment data to identify reasons why potential participants were reluctant to participate in the trial. We then investigated reasons the PWPs did not identify more potential participants. Finally, we performed retrospective analyses of a computerised clinical records system used by the IAPT services in this study. These analyses aimed to establish the number of potential participants who had not been approached about the trial as well as whether there were additional factors affecting the numbers of people who might be eligible to take part. Data were obtained for all patients assessed during the period from the date on which recruitment commenced until the closure of the trial.
Results
Three quarters of those patients identified as possibly suitable for the trial declined to take part; the great majority did so because they did not want to be randomly assigned to receive medication. Our retrospective database analyses showed that only around 12% of potentially eligible patients for the trial were identified by the PWPs at the pilot sites. The results also indicated that only 5% of those noted at entry to the IAPT services to have a score of at least 10 on the GAD-7 questionnaire (a self-completed questionnaire with high sensitivity and specificity for GAD) would have been eligible for the trial.
Conclusions
Our findings suggest that poor recruitment to RCTs can be significantly affected by participants’ treatment preferences and by factors influencing the recruiting clinicians. It may also be important not to include too many restrictions on inclusion criteria for pragmatic trials aiming for generalisable results
Emergences and affordances as opportunities to develop teachers’ mathematical content knowledge
Teachers’ mathematical content knowledge has been under scrutiny for some time. This development is in the wake of learners’ unsatisfactory performance in national examinations and international achievement tests. A widely held belief is that one, if not the most important, of the efforts to improve and enhance the performance and achievement in mathematics of learners is addressing teachers’ mathematical content and pedagogical content knowledge through continuous professional development initiatives. The focus of this article is on the former. It describes how emergent and affording opportunities are brought to the fore from classroom observations and interactions in workshops and institutes with practising teachers. It concludes that this in situ dealing with mathematical content knowledge holds much promise for buy-in by teachers because it addresses an immediate need related to their practice
Fluxes of trichloroacetic acid through a conifer forest canopy
Controlled-dosing experiments with conifer seedlings have demonstrated an aboveground
route of uptake for trichloroacetic acid (TCA) from aqueous solution into the
canopy, in addition to uptake from the soil. The aim of this work was to investigate
the loss of TCA to the canopy in a mature conifer forest exposed only to
environmental concentrations of TCA by analysing above- and below-canopy fluxes
of TCA and within-canopy instantaneous reservoir of TCA. Concentrations and fluxes
of TCA were quantified for one year in dry deposition, rainwater, cloudwater,
throughfall, stemflow and litterfall in a 37-year-old Sitka spruce and larch plantation
in SW Scotland. Above-canopy TCA deposition was dominated by rainfall (86%),
compared with cloudwater (13%) and dry deposition (1%). On average only 66% of
the TCA deposition passed through the canopy in throughfall and stemflow (95% and
5%, respectively), compared with 47% of the wet precipitation depth. Consequently,
throughfall concentration of TCA was, on average, 1.4 × rainwater concentration.
There was no significant difference in below-canopy fluxes between Sitka spruce and
larch, or at a forest-edge site. Annual TCA deposited from the canopy in litterfall was
only 1–2% of above-canopy deposition. On average, 800 μg m−2 of deposited TCA
was lost to the canopy per year, compared with estimates of above-ground TCA
storage of 400 and 300 μg m−2 for Sitka spruce and larch, respectively. Taking into
account likely uncertainties in these values (±50%), these data yield an estimate for
the half-life of within-canopy elimination of TCA in the range 50–200 days, assuming
steady-state conditions and that all TCA lost to the canopy is transferred into the
canopy material, rather than degraded externally. The observations provide strong
indication that an above-ground route is important for uptake of TCA specifically of
atmospheric origin into mature forest canopies, as has been shown for seedlings (in
addition to uptake from soil via transpiration), and that annualized within-canopy
elimination is similar to that in controlled-dosing experiments
Instabilities and disorder of the domain patterns in the systems with competing interactions
The dynamics of the domains is studied in a two-dimensional model of the
microphase separation of diblock copolymers in the vicinity of the transition.
A criterion for the validity of the mean field theory is derived. It is shown
that at certain temperatures the ordered hexagonal pattern becomes unstable
with respect to the two types of instabilities: the radially-nonsymmetric
distortions of the domains and the repumping of the order parameter between the
neighbors. Both these instabilities may lead to the transformation of the
regular hexagonal pattern into a disordered pattern.Comment: ReVTeX, 4 pages, 3 figures (postscript); submitted to Phys. Rev. Let
The Shapes of Flux Domains in the Intermediate State of Type-I Superconductors
In the intermediate state of a thin type-I superconductor magnetic flux
penetrates in a disordered set of highly branched and fingered macroscopic
domains. To understand these shapes, we study in detail a recently proposed
"current-loop" (CL) model that models the intermediate state as a collection of
tense current ribbons flowing along the superconducting-normal interfaces and
subject to the constraint of global flux conservation. The validity of this
model is tested through a detailed reanalysis of Landau's original conformal
mapping treatment of the laminar state, in which the superconductor-normal
interfaces are flared within the slab, and of a closely-related straight-lamina
model. A simplified dynamical model is described that elucidates the nature of
possible shape instabilities of flux stripes and stripe arrays, and numerical
studies of the highly nonlinear regime of those instabilities demonstrate
patterns like those seen experimentally. Of particular interest is the buckling
instability commonly seen in the intermediate state. The free-boundary approach
further allows for a calculation of the elastic properties of the laminar
state, which closely resembles that of smectic liquid crystals. We suggest
several new experiments to explore of flux domain shape instabilities,
including an Eckhaus instability induced by changing the out-of-plane magnetic
field, and an analog of the Helfrich-Hurault instability of smectics induced by
an in-plane field.Comment: 23 pages, 22 bitmapped postscript figures, RevTex 3.0, submitted to
Phys. Rev. B. Higher resolution figures may be obtained by contacting the
author
Governing processes for reactive nitrogen compounds in the atmosphere in relation to ecosystem climatic and human health impacts
Reactive nitrogen (Nr) compounds have different fates in the atmosphere due to differences in governing processes of physical transport, deposition and chemical transformation. Nr compounds addressed here include reduced nitrogen (NHx: ammonia (NH3) and its reaction product ammonium (NH4+)), oxidized nitrogen (NOy: nitrogen monoxide (NO) + nitrogen dioxide (NO2) and their reaction products) as well as organic nitrogen compounds (organic N). Pollution abatement strategies need to take into account these differences in the governing processes of these compounds when assessing their impact on ecosystem services, biodiversity, human health and climate. NOx (NO + NO2) emitted from traffic affects human health in urban areas where the presence of buildings increases the residence time in streets. In urban areas this leads to enhanced exposure of the population to NOx concentrations. NOx emissions have little impact on nearby ecosystems because of the small dry deposition rates of NOx. These compounds need to be converted into nitric acid (HNO3) before removal through deposition is efficient. HNO3 sticks quickly to any surface and is thereby either dry deposited or incorporated into aerosols as nitrate (NO3−). In contrast to NOx compounds, NH3 has potentially high impacts on ecosystems near the main agricultural sources of NH3 because of its large ground-level concentrations along with large dry deposition rates. Aerosol phase NH4+ and NO3− contribute significantly to background PM2.5 and PM10 (mass of aerosols with a diameter of less than 2.5 and 10 μm, respectively) with an impact on radiation balance as well as potentially on human health. Little is known quantitatively and qualitatively about organic N in the atmosphere, other than that it contributes a significant fraction of wet-deposited N, and is present in both gaseous and particulate forms in the atmosphere. Further studies are needed to characterize the sources, air chemistry and removal rates of organic N emissions
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