Asuhan Keperawatan Anak pada An. A dengan Dbd terhadap Penerapan Sari Kurma di Ruang Anyelir Rumah Sakit Embung Fatimah Kota Batam Tahun 2021

BACKGROUND: Dengue hemorrhagic fever was first recognized in Southeast Asia, more precisely in the Philippines in 1953, because of cases of fever that attacked children accompanied by bleeding and shock manifestations. The number of cases of dengue hemorrhagic fever (DHF) in Indonesia experienced a drastic spike in early 2020. The Ministry of Health noted that the number of cases of DHF in Indonesia had crossed the 16,000 mark, in the period from January to early March 2020. Of that number, 100 people died. The best way to avoid dengue is to adopt a healthy lifestyle (Suiraoka, 2012). One of them is in non-pharmacological treatment, namely by giving date palm juice, the method used is safer, easier and simpler (Reni, 2018).OBJECTIVE:  To apply nursing care to dengue hemorrhagic fever patients which includes assessment, diagnosis, intervention, implementation and evaluation. METHOD: The research design method used is descriptive using case studies. The respondents used were 1 pediatric patient with a medical diagnosis of Dengue Hemorrhagic Fever. RESULT: The application of nursing care in accordance with the nursing process will achieve good results in accordance with the predetermined outcome criteria. Giving nursing actions to drink date palm juice can increase the platelet value of An.A. And An. A is able to do therapy by drinking date juice independently. &nbsp

Synthetic oligodeoxynucleotide purification by polymerization of failure sequences

Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramiditefollowed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drugpurification

Selectivity Data: Assessment, Predictions, Concordance, and Implications

Could high-quality in silico predictions in drug discovery eventually replace part or most of experimental testing? To evaluate the agreement of selectivity data from different experimental or predictive sources, we introduce the new metric concordance minimum significant ratio (cMSR). Empowered by cMSR, we find the overall level of agreement between predicted and experimental data to be comparable to that found between experimental results from different sources. However, for molecules that are either highly selective or potent, the concordance between different experimental sources is significantly higher than the concordance between experimental and predicted values. We also show that computational models built from one data set are less predictive for other data sources and highlight the importance of bias correction for assessing selectivity data. Finally, we show that small-molecule target space relationships derived from different data sources and predictive models share overall similarity but can significantly differ in details

Small Molecule Antivirulents Targeting the Iron-Regulated Heme Oxygenase (HemO) of <i>P. aeruginosa</i>

Bacteria require iron for survival and virulence and employ several mechanisms including utilization of the host heme containing proteins. The final step in releasing iron is the oxidative cleavage of heme by HemO. A recent computer aided drug design (CADD) study identified several inhibitors of the bacterial HemOs. Herein we report the near complete HN, N, CO, Cα, and Cβ chemical shift assignment of the <i>P. aeruginosa</i> HemO in the absence and presence of inhibitors (<i>E</i>)-3-(4-(phenylamino)­phenylcarbamoyl)­acrylic acid (<b>3</b>) and (<i>E</i>)-<i>N</i>′-(4-(dimethylamino)­benzylidene) diazenecarboximidhydrazide (<b>5</b>). The NMR data confirm that the inhibitors bind within the heme pocket of HemO consistent with in silico molecular dynamic simulations. Both inhibitors and the phenoxy derivative of <b>3</b> have activity against <i>P. aeruginosa</i> clinical isolates. Furthermore, <b>5</b> showed antimicrobial activity in the in vivo C. elegans curing assay. Thus, targeting virulence mechanisms required within the host is a viable antimicrobial strategy for the development of novel antivirulants