The Intelligent System of the Hearing Investigation

This paper describes a prototype of the intelligent system of the hearing investigation developed by the Tver State Technical University. The problem of automatic diagnostics, considered as the recognition problem of object not completely determined on set of the diseases classes’ descriptions, is discussed. The management strategy of the hearing investigation is proposed

Extracting Muon Momentum Scale Corrections for Hadron Collider Experiments

We present a simple method for the extraction of corrections for bias in the measurement of the momentum of muons in hadron collider experiments. Such bias can originate from a variety of sources such as detector misalignment, software reconstruction bias, and uncertainties in the magnetic field. The two step method uses the mean for muons from $Z\to \mu\mu$ decays to determine the momentum scale corrections in bins of charge, $\eta$ and $\phi$. In the second step, the corrections are tuned by using the average invariant mass of $Z\to \mu\mu$ events in the same bins of charge $\eta$ and $\phi$. The forward-backward asymmetry of $Z/\gamma^{*} \to \mu\mu$ pairs as a function of $\mu^+\mu^-$ mass, and the $\phi$ distribution of $Z$ bosons in the Collins-Soper frame are used to ascertain that the corrections remove the bias in the momentum measurements for positive versus negatively charged muons. By taking the sum and difference of the momentum scale corrections for positive and negative muons, we isolate additive corrections to $1/p^\mu_T$ that may originate from misalignments and multiplicative corrections that may originate from mis-modeling of the magnetic field $(\int \vec{B} \cdot d\vec{L})$. This method has recently been used in the CDF experiment at Fermilab and in the CMS experiment at the Large Hadron Collider at CERNComment: 6 pages, 3 figures, to be published in EPJC 201

C-A test of DNA force fields

The DNA duplex may be locally strongly bent in complexes with proteins, for example, with polymerases or in a nucleosome. At such bends, the DNA helix is locally in the non-canonical forms A (with a narrow major groove and a large amount of north sugars) or C (with a narrow minor groove and a large share of BII phosphates). To model the formation of such complexes by molecular dynamics methods, the force field is required to reproduce these conformational transitions for a naked DNA. We analyzed the available experimental data on the B-C and B-A transitions under the conditions easily implemented in modeling: in an aqueous NaCl solution. We selected six DNA duplexes which conformations at different salt concentrations are known reliably enough. At low salt concentrations, poly(GC) and poly(A) are in the B-form, classical and slightly shifted to the A-form, respectively. The duplexes ATAT and GGTATACC have a strong and salt concentration dependent bias toward the A-form. The polymers poly(AC) and poly(G) take the C- and A-forms, respectively, at high salt concentrations. The reproduction of the behavior of these oligomers can serve as a test for the balance of interactions between the base stacking and the conformational flexibility of the sugar-phosphate backbone in a DNA force field. We tested the AMBER bsc1 and CHARMM36 force fields and their hybrids, and we failed to reproduce the experiment. In all the force fields, the salt concentration dependence is very weak. The known B-philicity of the AMBER force field proved to result from the B-philicity of its excessively strong base stacking. In the CHARMM force field, the B-form is a result of a fragile balance between the A-philic base stacking (especially for G:C pairs) and the C-philic backbone. Finally, we analyzed some recent simulations of the LacI-, SOX-4-, and Sac7d-DNA complex formation in the framework of the AMBER force field.Comment: 14 pages, 4 figures plus one TOC picture, 5 table

Triggering near‐infrared luminescence of vanadyl phthalocyanine by charging

Probing electrofluorochromism (EFC) at the molecular level remains challenging. Here we study the strongly charge state‐dependent photoluminescence of vanadyl phthalocyanine. We report vibrationally resolved absorption and laser‐induced fluorescence (LIF) spectra of samples comprising both the mass‐selected neutral molecule (VOPc⋅, a stable radical) and its cation produced upon electron ionization (EI) isolated in 5 K neon matrices. Ionization of the essentially non‐emissive VOPc⋅ forms a high‐spin diradical cation (VOPc(+..)) which shows profound photoluminescence (PL) in the NIR range. This unique phenomenon is potentially of interest for NIR‐emitting electro‐optic devices

On the Short-Term Variability of Turbulence and Temperature in the Winter Mesosphere

Four mesosphere–lower thermosphere temperature and turbulence profiles were obtained in situ within ∼30 min and over an area of about 100 by 100 km during a sounding rocket experiment conducted on 26 January 2015 at Poker Flat Research Range in Alaska. In this paper we examine the spatial and temporal variability of mesospheric turbulence in relationship to the static stability of the background atmosphere. Using active payload attitude control, neutral density fluctuations, a tracer for turbulence, were observed with very little interference from the payload spin motion, and with high precision (%) at sub-meter resolution. The large-scale vertical temperature structure was very consistent between the four soundings. The mesosphere was almost isothermal, which means more stratified, between 60 and 80 km, and again between 88 and 95 km. The stratified regions adjoined quasi-adiabatic regions assumed to be well mixed. Additional evidence of vertical transport and convective activity comes from sodium densities and trimethyl aluminum trail development, respectively, which were both observed simultaneously with the in situ measurements. We found considerable kilometer-scale temperature variability with amplitudes of 20 K in the stratified region below 80 km. Several thin turbulent layers were embedded in this region, differing in width and altitude for each profile. Energy dissipation rates varied between 0.1 and 10 mW kg−1, which is typical for the winter mesosphere. Very little turbulence was observed above 82 km, consistent with very weak small-scale gravity wave activity in the upper mesosphere during the launch night. On the other hand, above the cold and prominent mesopause at 102 km, large temperature excursions of +40 to +70 K were observed. Simultaneous wind measurements revealed extreme wind shears near 108 km, and combined with the observed temperature gradient, isolated regions of unstable Richardson numbers (0Kp∼5)

Spatial and Temporal Variability in MLT Turbulence Inferred from in situ and Ground-Based Observations During the WADIS-1 Sounding Rocket Campaign

In summer 2013 the WADIS-1 sounding rocket campaign was conducted at the Andøya Space Center (ACS) in northern Norway (69° N, 16° E). Among other things, it addressed the question of the variability in mesosphere/lower thermosphere (MLT) turbulence, both in time and space. A unique feature of the WADIS project was multi-point turbulence sounding applying different measurement techniques including rocket-borne ionization gauges, VHF MAARSY radar, and VHF EISCAT radar near Tromsø. This allowed for horizontal variability to be observed in the turbulence field in the MLT at scales from a few to 100 km. We found that the turbulence dissipation rate, ε varied in space in a wavelike manner both horizontally and in the vertical direction. This wavelike modulation reveals the same vertical wavelengths as those seen in gravity waves. We also found that the vertical mean value of radar observations of ε agrees reasonably with rocket-borne measurements. In this way defined 〈εradar〉 value reveals clear tidal modulation and results in variation by up to 2 orders of magnitude with periods of 24 h. The 〈εradar〉 value also shows 12 h and shorter (1 to a few hours) modulations resulting in one decade of variation in 〈εradar〉 magnitude. The 24 h modulation appeared to be in phase with tidal change of horizontal wind observed by SAURA-MF radar. Such wavelike and, in particular, tidal modulation of the turbulence dissipation field in the MLT region inferred from our analysis is a new finding of this work