Metabolic responses to short-term high-fat overfeeding

The main aim of this thesis was to increase our understanding of the metabolic responses associated with short-term high-fat overfeeding. To this end, four separate studies are described in this thesis; each of which involved the provision of a high-fat, high-energy diet to young, healthy, lean individuals. The first of these experimental chapters (Chapter 2) determined the effects of a 7-day, high-fat (65%), high-energy (+50%) diet on postprandial metabolic and endocrine responses to a mixed meal challenge. This chapter demonstrates that 7-days of overfeeding impaired glycaemic control in our subject cohort but did not influence the response of selected gut hormones (acylated ghrelin, GLP-1 and GIP). In a mechanistic follow up study utilising stable isotope tracer methodology we then demonstrate that overfeeding-induced impairments in glycaemic control are attributable to subtle alterations in plasma glucose flux, rather than the overt tissue-specific adaptations (e.g. increased EGP, or reduced glucose disposal) that have previously been reported (Chapter 3). In an attempt to delineate the time-course of diet-induced impairments in glycaemic control, we then investigated the effects of 1-day of overfeeding (+80% energy with 73% of total energy coming as fat) (Chapter 4). Results demonstrate that a single day of overfeeding elicits responses which are comparable to 7-days of high-fat overfeeding; highlighting the rapidity with which excessive high-fat food intake can negatively influence glucose metabolism. In chapter 5 we utilised stable isotope tracer and muscle biopsy techniques to demonstrate that 7-days of high-fat overfeeding impairs glycaemic control but does not influence the fed-state mixed muscle protein fractional synthesis rate (FSR). In conclusion, the findings of this thesis demonstrate that while short-term high-fat overfeeding negatively influences whole-body glucose metabolism, skeletal muscle protein metabolism appears to be relatively unaffected in young, lean, healthy humans

The Amazing Old Nova Q Cygni: A Far Ultraviolet Synthetic Spectral Analysis

Q Cygni (Nova Cygni 1876) is the third oldest old novae (after WY Sge and V841 Oph) with a long orbital period of 10.08 hours and spectroscopic peculiarities in the optical including the presence of variable wind outflow revealed by optical P Cygni profiles in the HeI lines and H alpha beta (Kafka et al. 2003). We have carried out a synthetic spectral analysis of a far ultraviolet IUE archival spectrum of Q Cygni using our optically thick, steady state, accretion disk models and model white dwarf photospheres. We find that the accretion light of a luminous accretion disk dominates the FUV flux of the hot component with a rate of accretion 2-3 1.E-9 Msun/yr. We find that Q Cygni lies at a distance of 741 \pm 110 pc . The implications of our results for theoretical predictions for old novae are presented.Comment: PASP, August 201

Dwarf nova oscillations and quasi-periodic oscillations in cataclysmic variables - VII. OY Carinae and oscillations in dwarf novae in quiescence

We have observed dwarf nova oscillations (DNOs) in OY Car during outburst, down through decline and beyond; its behaviour is similar to what we have previously seen in VW Hyi, making it only the second dwarf nova to have DNOs late in outburst that continue well into quiescence. There are also occasional examples of DNOs in deep quiescence, well away from outburst - they have properties similar to those during outburst, indicating similar physical causes and structures. We discuss the occurrence of DNOs in other dwarf novae and conclude that DNOs during quiescence are more common than often supposed and exhibit properties similar to those seen in outburst.Comment: Accepted for publication in MNRAS; paper contains 11 figures and 2 tables. This paper has become paper VII in the serie

Bahya Ibn Pakuda, Tutor of Hearts

This essay examines the philosophical and scholastic threads woven through Bahya Ibn Pakuda\u27s An Introduction to the Duties of Hearts

FUSE Observations of the Dwarf Novae UU Aql, BV Cen, and CH UMa in Quiescence

We report on FUSE spectra of three U Gem-type, long period, dwarf novae, UU Aql, BV Cen and CH UMa taken during their quiescence intervals. We discuss the line identifications in their spectra and attempt to characterize the source(s) of their FUV flux distribution. Archival IUE spectrum of CH UMa and BV Cen in quiescence were identified as having a matching flux level with the FUSE spectra and these were combined with each FUSE spectrum to broaden the wavelength coverage and further constrain model fits. Multi-component synthetic spectral fits from our model grids, consisting of single temperature white dwarfs, two-temperature white dwarfs, accretion disks and white dwarfs plus accretion disks, were applied to the FUSE spectra alone and to the combined FUSE + IUE spectra. We present the results of our model analyses and their implications.Comment: accepted in AJ, 26 pages, 6 tables, 8 figures (5 color, 3 b/w

Shortest Path Computation with No Information Leakage

Shortest path computation is one of the most common queries in location-based services (LBSs). Although particularly useful, such queries raise serious privacy concerns. Exposing to a (potentially untrusted) LBS the client's position and her destination may reveal personal information, such as social habits, health condition, shopping preferences, lifestyle choices, etc. The only existing method for privacy-preserving shortest path computation follows the obfuscation paradigm; it prevents the LBS from inferring the source and destination of the query with a probability higher than a threshold. This implies, however, that the LBS still deduces some information (albeit not exact) about the client's location and her destination. In this paper we aim at strong privacy, where the adversary learns nothing about the shortest path query. We achieve this via established private information retrieval techniques, which we treat as black-box building blocks. Experiments on real, large-scale road networks assess the practicality of our schemes.Comment: VLDB201

Far Ultraviolet Spectroscopic Explorer Spectroscopy of the Nova-like BB Doradus

We present an analysis of the Far Ultraviolet Spectroscopic Explorer ({\it{FUSE}}) spectra of the little-known southern nova-like BB Doradus. The spectrum was obtained as part of our Cycle 8 {\it FUSE} survey of high declination nova-like stars. The FUSE spectrum of BB Dor, observed in a high state, is modeled with an accretion disk with a very low inclination (possibly lower than 10deg). Assuming an average WD mass of 0.8 solar leads to a mass accretion rate of 1.E-9 Solar mass/year and a distance of the order of 650 pc, consistent with the extremely low galactic reddening in its direction. The spectrum presents some broad and deep silicon and sulfur absorption lines, indicating that these elements are over-abundant by 3 and 20 times solar, respectively

On high proper motion white dwarfs from photographic surveys

The interpretation of high proper motion white dwarfs detected by Oppenheimer et al (2001) was the start of a lively controversy. While the discoverers identify a large fraction of their findings as dark halo members, others interpret the same sample as essentially made of disc and/or thick disc stars. We use the comprehensive description of Galactic stellar populations provided by the "Besancon" model to produce a realistic simulation of Oppenheimer et al. data, including all observational selections and calibration biases. The conclusion is unambiguous: Thick disc white dwarfs resulting from ordinary hypotheses on the local density and kinematics are sufficient to explain the observed objects, there is no need for halo white dwarfs. This conclusion is robust to reasonable changes in model ingredients. The main cause of the misinterpretation seems to be that the velocity distribution of a proper motion selected star sample is severely biased in favour of high velocities. This has been neglected in previous analyses. Obviously this does not prove that no such objects like halo white dwarfs can exist, but Oppenheimer et al. observations drive their possible contribution in the dark matter halo down to an extremely low fraction.Comment: 4 pages, 1 figure, A&A Letters, accepte

Primed: Medicaid Pilots Open Door for Innovation in California

The United States health care system is undergoing a major transition from volume-based to value-based care. In California, health care pilots and initiatives offer financial incentives to clinics, hospitals, and health plans to accelerate this transition in order to better serve the state's nearly 14 million safety-net patients.Safety-net organizations must succeed in California's new Medicaid incentive programs in order to remain financially solvent. To carry out these pilots, providers and plans need high-value innovation that engages patients outside of the clinical setting, makes data accessible and usable for all health system staff, and enhances coordination between the health system and its external partners