673 research outputs found
The 11.2 m emission of PAHs in astrophysical objects
The 11.2 m emission band belongs to the family of the `Unidentified'
Infrared (UIR) emission bands seen in many astronomical environments. In this
work we present a theoretical interpretation of the band characteristics and
profile variation for a number of astrophysical sources in which the carriers
are subject to a range of physical conditions. The results of Density
Functional Theory (DFT) calculations for the solo out-of-plane (OOP)
vibrational bending modes of large polycyclic aromatic hydrocarbon (PAH)
molecules are used as input for a detailed emission model which includes the
temperature and mass dependence of PAH band wavelength, and a PAH mass
distribution that varies with object. Comparison of the model with astronomical
spectra indicates that the 11.2 m band asymmetry and profile variation can
be explained principally in terms of the mass distribution of neutral PAHs with
a small contribution from anharmonic effects.Comment: 13 pages, 10 figures, 3 table. Accepted for publication in MNRA
Polycyclic Aromatic Hydrocarbons with armchair edges and the 12.7 {\mu}m band
In this Letter we report the results of density functional theory
calculations on medium-sized neutral Polycyclic Aromatic Hydrocarbon (PAH)
molecules with armchair edges. These PAH molecules possess strong C-H
stretching and bending modes around 3 {\mu}m and in the fingerprint region
(10-15 {\mu}m), and also strong ring deformation modes around 12.7 {\mu}m.
Perusal of the entries in the NASA Ames PAHs Database shows that ring
deformation modes of PAHs are common - although generally weak. We then propose
that armchair PAHs with NC >65 are responsible for the 12.7 {\mu}m Aromatic
Infrared Band in HII regions and discuss astrophysical implications in the
context of the PAH life-cycle.Comment: Minor editin
Diffuse Interstellar Bands in z < 0.6 CaII Absorbers
The diffuse interstellar bands (DIBs) probably arise from complex organic
molecules whose strength in local galaxies correlates with neutral hydrogen
column density, N(HI), and dust reddening, E(B-V). Since CaII absorbers in
quasar (QSO) spectra are posited to have high N(HI) and significant E(B-V),
they represent promising sites for the detection of DIBs at cosmological
distances. Here we present the results from the first search for DIBs in 9
CaII-selected absorbers at 0.07 < z_abs < 0.55. We detect the 5780Ang DIB in
one line of sight at z_abs = 0.1556; this is only the second QSO absorber in
which a DIB has been detected. Unlike the majority of local DIB sight-lines,
both QSO absorbers with detected DIBs show weak 6284Ang absorption compared
with the 5780Ang band. This may be indicative of different physical conditions
in intermediate redshift QSO absorbers compared with local galaxies. Assuming
that local relations between the 5780Ang DIB strength and N(HI) and E(B-V)
apply in QSO absorbers, DIB detections and limits can be used to derive N(HI)
and E(B-V). For the one absorber in this study with a detected DIB, we derive
E(B-V) = 0.23mag and log[N(HI)] >= 20.9, consistent with previous conclusions
that CaII systems have high HI column densities and significant reddening. For
the remaining 8 CaII-selected absorbers with 5780Ang DIB non-detections, we
derive E(B-V) upper limits of 0.1-0.3mag.Comment: 5 pages, 2 figures. Accepted to MNRAS Letter
Optical spectrum of proflavine and its ions
Motivated by possible astrophysical and biological applications we calculate
visible and near UV spectral lines of proflavine (C13H11N3,
3,6-diaminoacridine) in vacuum, as well as its anion, cation, and dication. The
pseudopotential density functional and time-dependent density functional
methods are used. We find a good agreement in spectral line positions
calculated by two real-time propagation methods and the Lanczos chain method.
Spectra of proflavine and its ions show characteristic UV lines which are good
candidates for a detection of these molecules in interstellar space and various
biological processes
A survey of diffuse interstellar bands in the Andromeda galaxy: optical spectroscopy of M31 OB stars
We present the largest sample to-date of intermediate-resolution blue-to-red
optical spectra of B-type supergiants in M31 and undertake the first survey of
diffuse interstellar bands (DIBs) in this galaxy. Spectral classifications,
radial velocities and interstellar reddenings are presented for 34 stars in
three regions of M31. Radial velocities and equivalent widths are given for the
5780 and 6283 DIBs towards 11 stars. Equivalent widths are also presented for
the following DIBs detected in three sightlines in M31: 4428, 5705, 5780, 5797,
6203, 6269, 6283, 6379, 6613, 6660, and 6993. All of these M31 DIB carriers
reside in clouds at radial velocities matching those of interstellar Na I
and/or H I. The relationships between DIB equivalent widths and reddening
(E(B-V)) are consistent with those observed in the local ISM of the Milky Way.
Many of the observed sightlines show DIB strengths (per unit reddening) which
lie at the upper end of the range of Galactic values. DIB strengths per unit
reddening are found (with 68% confidence), to correlate with the interstellar
UV radiation field strength. The strongest DIBs are observed where the
interstellar UV flux is lowest. The mean Spitzer 8/24 micron emission ratio in
our three fields is slightly lower than that measured in the Milky Way, but we
identify no correlation between this ratio and the DIB strengths in M31.
Interstellar oxygen abundances derived from the spectra of three M31 H II
regions in one of the fields indicate that the average metallicity of the ISM
in that region is 12 + log[O/H] = 8.54 +- 0.18, which is approximately equal to
the value in the solar neighbourhood
Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart.
AIMS: Notch1 signalling in the heart is mainly activated via expression of Jagged1 on the surface of cardiomyocytes. Notch controls cardiomyocyte proliferation and differentiation in the developing heart and regulates cardiac remodelling in the stressed adult heart. Besides canonical Notch receptor activation in signal-receiving cells, Notch ligands can also activate Notch receptor-independent responses in signal-sending cells via release of their intracellular domain. We evaluated therefore the importance of Jagged1 (J1) intracellular domain (ICD)-mediated pathways in the postnatal heart.
METHODS AND RESULTS: In cardiomyocytes, Jagged1 releases J1ICD, which then translocates into the nucleus and down-regulates Notch transcriptional activity. To study the importance of J1ICD in cardiac homeostasis, we generated transgenic mice expressing a tamoxifen-inducible form of J1ICD, specifically in cardiomyocytes. Using this model, we demonstrate that J1ICD-mediated Notch inhibition diminishes proliferation in the neonatal cardiomyocyte population and promotes maturation. In the neonatal heart, a response via Wnt and Akt pathway activation is elicited as an attempt to compensate for the deficit in cardiomyocyte number resulting from J1ICD activation. In the stressed adult heart, J1ICD activation results in a dramatic reduction of the number of Notch signalling cardiomyocytes, blunts the hypertrophic response, and reduces the number of apoptotic cardiomyocytes. Consistently, this occurs concomitantly with a significant down-regulation of the phosphorylation of the Akt effectors ribosomal S6 protein (S6) and eukaryotic initiation factor 4E binding protein1 (4EBP1) controlling protein synthesis.
CONCLUSIONS: Altogether, these data demonstrate the importance of J1ICD in the modulation of physiological and pathological hypertrophy, and reveal the existence of a novel pathway regulating cardiac homeostasis
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