1,537 research outputs found
Incorporating sustainable forestry into standards for professional forestry education
In 1991, the National Association of Professional Forestry Schools and Colleges (NAPFSC) and the Society of American Foresters (SAF) co-hosted a three-day Forest Resources Education Symposium, entitled Forest Resources Management in the 21st Century: Will Forestry Education Meet the Challenge? The objectives of the national symposium were to present major forces shaping the country\u27s management of forest resources, and then to discuss the adequacy of educational criteria in preparing tomorrow\u27s resource managers to excel under an expanding array of consumer and employer demands. As an outcome, the discussants developed a summary of specific challenges and solutions within five issue areas: The Future of Forestry, Future Educational Needs, Defining Appropriate Curricula, Student Characteristics, and Faculty Characteristics. Many existing problems were identified as a result of that process, as well as potentially useful strategies for corrective action
From Playboy to Prison: When Pornography Use Becomes a Crime
This study explores pornography use across the lifespan for a sample of registrants convicted of child pornography related offenses. We conducted qualitative life history interviews with nine offenders to examine how offender, victim, and situational factors interact to produce pornography related criminal events. Using a hybrid analytic approach, themes related to persistence in pornography use and the social acceptability of pornography are identified. These themes relate to transitions from legal pornography use to illegal child pornography possession
Cooperative action in eukaryotic gene regulation: physical properties of a viral example
The Epstein-Barr virus (EBV) infects more than 90% of the human population,
and is the cause of several both serious and mild diseases. It is a
tumorivirus, and has been widely studied as a model system for gene
(de)regulation in human. A central feature of the EBV life cycle is its ability
to persist in human B cells in states denoted latency I, II and III. In latency
III the host cell is driven to cell proliferation and hence expansion of the
viral population, but does not enter the lytic pathway, and no new virions are
produced, while the latency I state is almost completely dormant. In this paper
we study a physico-chemical model of the switch between latency I and latency
III in EBV. We show that the unusually large number of binding sites of two
competing transcription factors, one viral and one from the host, serves to
make the switch sharper (higher Hill coefficient), either by cooperative
binding between molecules of the same species when they bind, or by competition
between the two species if there is sufficient steric hindrance.Comment: 7 pages, 6 figures, 1 tabl
Epstein-Barr virus IL-10 gene expression by a recombinant murine gammaherpesvirus in vivo enhances acute pathogenicity but does not affect latency or reactivation.
BackgroundMany viral genes affect cytokine function within infected hosts, with interleukin 10 (IL-10) as a commonly targeted mediator. Epstein-Barr virus (EBV) encodes an IL-10 homologue (vIL-10) expressed during productive (lytic) infection and induces expression of cellular IL-10 (cIL-10) during latency. This study explored the role of vIL-10 in a murine gammaherpesvirus (MHV) model of viral infection.MethodsThe EBV vIL-10 gene was inserted into MHV-76, a strain which lacks the ability to induce cIL-10, by recombination in transfected mouse cells. Mice were infected intranasally with the recombinant, vIL-10-containing MHV-76 or control virus strains and assayed at various days post infection for lung virus titer, spleen cell number, percentage of latently infected spleen cells and ability to reactivate virus from spleen cells.ResultsRecombinant murine gammaherpesvirus expressing EBV vIL-10 rose to significantly higher titers in lungs and promoted an increase in spleen cell number in infected mice in comparison to MHV strains lacking the vIL-10 gene. However, vIL-10 expression did not alter the quantity of latent virus in the spleen or its ability to reactivate.ConclusionsIn this mouse model of gammaherpesvirus infection, EBV vIL-10 appears to influence acute-phase pathogenicity. Given that EBV and MHV wild-type strains contain other genes that induce cIL-10 expression in latency (e.g. LMP-1 and M2, respectively), vIL-10 may have evolved to serve the specific role in acute infection of enlarging the permissive host cell population, perhaps to facilitate initial survival and dissemination of viral-infected cells
The effect of carrier density gradients on magnetotransport data measured in Hall bar geometry
We have measured magnetotransport of the two-dimensional electron gas in a
Hall bar geometry in the presence of small carrier density gradients. We find
that the longitudinal resistances measured at both sides of the Hall bar
interchange by reversing the polarity of the magnetic field. We offer a simple
explanation for this effect and discuss implications for extracting
conductivity flow diagrams of the integer quantum Hall effect.Comment: 7 pages, 8 figure
Integrated water resources management in North Georgia implications of wastewater management policy
Water management in the southeast, and
particularly in Georgia, has become increasingly more
complex due to rapid population growth, dwindling water
supplies, water quality and instream flow concerns, and
allocation disputes with neighboring states. The Georgia
state legislature responded with two key initiatives: SB
130, passed in 2001, which formed the Metropolitan North
Georgia Water Planning District (MNGWPD), and HB
237, passed in 2004, which requires the development of a
Comprehensive Statewide Water Plan (CSWP). In 2003,
the MNGWPD adopted wastewater management,
watershed protection, and water supply and conservation
plans that will guide water resources in metropolitan
Atlanta for the next 30 years.
Implementation costs of the MNGWPD water and
wastewater plans through 2030 has been estimated to total
$60B. To conserve financial resources and encourage a
sustainable development pattern, it is necessary to
prioritize these investments, i.e., focus investments upon
areas have the ability to increase population density due to
the proximity of existing services. Currently, growth
management policies in some jurisdictions encourage
septic system development, increasing overall wastewater
treatment costs and interfering with water management
goals.Sponsored by:
Georgia Environmental Protection Division
U.S. Geological Survey, Georgia Water Science Center
U.S. Department of Agriculture, Natural Resources Conservation Service
Georgia Institute of Technology, Georgia Water Resources Institute
The University of Georgia, Water Resources Facult
Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler
<p>Abstract</p> <p>Background</p> <p>The rate of emergence of human pathogens is steadily increasing; most of these novel agents originate in wildlife. Bats, remarkably, are the natural reservoirs of many of the most pathogenic viruses in humans. There are two bat genome projects currently underway, a circumstance that promises to speed the discovery host factors important in the coevolution of bats with their viruses. These genomes, however, are not yet assembled and one of them will provide only low coverage, making the inference of most genes of immunological interest error-prone. Many more wildlife genome projects are underway and intend to provide only shallow coverage.</p> <p>Results</p> <p>We have developed a statistical method for the assembly of gene families from partial genomes. The method takes full advantage of the quality scores generated by base-calling software, incorporating them into a complete probabilistic error model, to overcome the limitation inherent in the inference of gene family members from partial sequence information. We validated the method by inferring the human IFNA genes from the genome trace archives, and used it to infer 61 type-I interferon genes, and single type-II interferon genes in the bats <it>Pteropus vampyrus </it>and <it>Myotis lucifugus</it>. We confirmed our inferences by direct cloning and sequencing of IFNA, IFNB, IFND, and IFNK in <it>P. vampyrus</it>, and by demonstrating transcription of some of the inferred genes by known interferon-inducing stimuli.</p> <p>Conclusion</p> <p>The statistical trace assembler described here provides a reliable method for extracting information from the many available and forthcoming partial or shallow genome sequencing projects, thereby facilitating the study of a wider variety of organisms with ecological and biomedical significance to humans than would otherwise be possible.</p
Persistent Teaching Practices After Geospatial Technology Professional Development
This case study described teachers with varying technology skills who were implementing the use of geospatial technology (GST) within project-based instruction (PBI) at varying grade levels and contexts 1 to 2 years following professional development. The sample consisted of 10 fifth- to ninth-grade teachers. Data sources included artifacts, observations, interviews, and a GST performance assessment and were analyzed using a constant comparative approach. Teachers’ teaching actions, beliefs, context, and technology skills were categorized. Results indicated that all of the teachers had high beliefs, but their context and level of technology skills strongly influenced their teaching actions. Two types of teachers persisting in practices from professional development were identified: innovators and adapters. Persistence of practice and implementation of the integration of GST within PBI must continue after professional development ends, or the sustainability of the positive results experienced during the professional development will not persist
Persistent Teaching Practices After Geospatial Technology Professional Development
This case study described teachers with varying technology skills who were implementing the use of geospatial technology (GST) within project-based instruction (PBI) at varying grade levels and contexts 1 to 2 years following professional development. The sample consisted of 10 fifth- to ninth-grade teachers. Data sources included artifacts, observations, interviews, and a GST performance assessment and were analyzed using a constant comparative approach. Teachers’ teaching actions, beliefs, context, and technology skills were categorized. Results indicated that all of the teachers had high beliefs, but their context and level of technology skills strongly influenced their teaching actions. Two types of teachers persisting in practices from professional development were identified: innovators and adapters. Persistence of practice and implementation of the integration of GST within PBI must continue after professional development ends, or the sustainability of the positive results experienced during the professional development will not persist
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