Foreground removal requirements for measuring large-scale CMB B-modes in light of BICEP2

The most convincing confirmation that the B-mode polarization signal detected at degree scales by BICEP2 is due to the Cosmic Microwave Background (CMB) would be the measurement of its large-scale counterpart. We assess the requirements for diffuse component separation accuracy over large portions of the sky in order to measure the large-scale B-mode signal corresponding to a tensor to scalar ratio of r=0.1-0.2. We use the method proposed by Bonaldi & Ricciardi (2011) to forecast the performances of different simulated experiments taking into account noise and foreground removal issues. We do not consider instrumental systematics, and we implicitly assume that they are not the dominant source of error. If this is the case, the confirmation of an r=0.1-0.2 signal is achievable by Planck even for conservative assumptions regarding the accuracy of foreground cleaning. Our forecasts suggest that the combination of this experiment with BICEP2 will lead to an improvement of 25-45% in the constraint on r. A next-generation CMB polarization satellite, represented in this work by the COrE experiment, can reduce dramatically (by almost another order of magnitude) the uncertainty on r. In this case, however, the accuracy of foreground removal becomes critical to fully benefit from the increase in sensitivity.Comment: 8 pages, 3 figures, 1 table. Accepted by MNRA

A chemically driven fluctuating ratchet model for actomyosin interaction

With reference to the experimental observations by T. Yanagida and his co-workers on actomyosin interaction, a Brownian motor of fluctuating ratchet kind is designed with the aim to describe the interaction between a Myosin II head and a neighboring actin filament. Our motor combines the dynamics of the myosin head with a chemical external system related to the ATP cycle, whose role is to provide the energy supply necessary to bias the motion. Analytical expressions for the duration of the ATP cycle, for the Gibbs free energy and for the net displacement of the myosin head are obtained. Finally, by exploiting a method due to Sekimoto (1997, J. Phys. Soc. Jpn., 66, 1234), a formula is worked out for the amount of energy consumed during the ATP cycle.Comment: 15 pages. 1 figur

WMAP 3yr data with the CCA: anomalous emission and impact of component separation on the CMB power spectrum

The Correlated Component Analysis (CCA) allows us to estimate how the different diffuse emissions mix in CMB experiments, exploiting also complementary information from other surveys. It is especially useful to deal with possible additional components. An application of CCA to WMAP maps assuming that only the canonical Galactic emissions are present, highlights the widespread presence of a spectrally flat "synchrotron" component, largely uncorrelated with the synchrotron template, suggesting that an additional foreground is indeed required. We have tested various spectral shapes for such component, namely a power law as expected if it is flat synchrotron, and two spectral shapes that may fit the spinning dust emission: a parabola in the logS - log(frequency) plane, and a grey body. Quality tests applied to the reconstructed CMB maps clearly disfavour two of the models. The CMB power spectra, estimated from CMB maps reconstructed exploiting the three surviving foreground models, are generally consistent with the WMAP ones, although at least one of them gives a significantly higher quadrupole moment than found by the WMAP team. Taking foreground modeling uncertainties into account, we find that the mean quadrupole amplitude for the three "good" models is less than 1 sigma below the expectation from the standard LambdaCDM model. Also the other reported deviations from model predictions are found not to be statistically significant, except for the excess power at l~40. We confirm the evidence for a marked North-South asymmetry in the large scale (l < 20) CMB anisotropies. We also present a first, albeit preliminary, all-sky map of the "anomalous" component.Comment: 14 pages, 17 figures, submitted to MNRAS, references adde

Forecast B-modes detection at large scales in presence of noise and foregrounds

We investigate the detectability of the primordial CMB polarization B-mode power spectrum on large scales in the presence of instrumental noise and realistic foreground contamination. We have worked out a method to estimate the errors on component separation and to propagate them up to the power spectrum estimation. The performances of our method are illustrated by applying it to the instrumental specifications of the Planck satellite and to the proposed configuration for the next generation CMB polarization experiment COrE. We demonstrate that a proper component separation step is required in order achieve the detection of B-modes on large scales and that the final sensitivity to B-modes of a given experiment is determined by a delicate balance between noise level and residual foregrounds, which depend on the set of frequencies exploited in the CMB reconstruction, on the signal-to-noise of each frequency map, and on our ability to correctly model the spectral behavior of the foreground components. We have produced a flexible software tool that allows the comparison of performances on B-mode detection of different instrumental specifications (choice of frequencies, noise level at each frequency, etc.) as well as of different proposed approaches to component separation.Comment: 7 pages, 2 tables, 1 figure, accepted by MNRA

Biological aspects of mTOR in leukemia

The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival. Strong evidences have indicated that mTOR dysregulation is deeply implicated in leukemogenesis. This has led to growing interest in the development of modulators of its activity for leukemia treatment. This review intends to provide an outline of the principal biological and molecular functions of mTOR. We summarize the current understanding of how mTOR interacts with microRNAs, with components of cell metabolism, and with controllers of apoptotic machinery. Lastly, from a clinical/translational perspective, we recapitulate the therapeutic results in leukemia, obtained by using mTOR inhibitors as single agents and in combination with other compounds

Metabolic reprogramming promotes myogenesis during aging

Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia

Correlated Component Analysis for diffuse component separation with error estimation on simulated Planck polarization data

We present a data analysis pipeline for CMB polarization experiments, running from multi-frequency maps to the power spectra. We focus mainly on component separation and, for the first time, we work out the covariance matrix accounting for errors associated to the separation itself. This allows us to propagate such errors and evaluate their contributions to the uncertainties on the final products.The pipeline is optimized for intermediate and small scales, but could be easily extended to lower multipoles. We exploit realistic simulations of the sky, tailored for the Planck mission. The component separation is achieved by exploiting the Correlated Component Analysis in the harmonic domain, that we demonstrate to be superior to the real-space application (Bonaldi et al. 2006). We present two techniques to estimate the uncertainties on the spectral parameters of the separated components. The component separation errors are then propagated by means of Monte Carlo simulations to obtain the corresponding contributions to uncertainties on the component maps and on the CMB power spectra. For the Planck polarization case they are found to be subdominant compared to noise.Comment: 17 pages, accepted in MNRA

Sign-changing tower of bubbles for a sinh-Poisson equation with asymmetric exponents

Motivated by the statistical mechanics description of stationary 2D-turbulence, for a sinh-Poisson type equation with asymmetric nonlinearity, we construct a concentrating solution sequence in the form of a tower of singular Liouville bubbles, each of which has a different degeneracy exponent. The asymmetry parameter $\gamma\in(0,1]$ corresponds to the ratio between the intensity of the negatively rotating vortices and the intensity of the positively rotating vortices. Our solutions correspond to a superposition of highly concentrated vortex configurations of alternating orientation; they extend in a nontrivial way some known results for $\gamma=1$. Thus, by analyzing the case $\gamma\neq1$ we emphasize specific properties of the physically relevant parameter $\gamma$ in the vortex concentration phenomena

Nuclear expansion and symmetry energy of hot nuclei

The decrease in the symmetry energy of hot nuclei populated in $^{58}$Ni + $^{58}$Ni, $^{58}$Fe + $^{58}$Ni and $^{58}$Fe + $^{58}$Fe reactions at beam energies of 30, 40, and 47 MeV/nucleon, as a function of excitation energy is studied. It is observed that this decrease is mainly a consequence of increasing expansion or decreasing density rather than the increasing temperature. The results are in good agreement with the recently reported microscopic calculation based on the Thomas-Fermi approach. An empirical relation to study the symmetry energy of finite nuclei in various mass region is proposed.Comment: 10 pages, 2 figure

Functional outcome after lower limb amputation: is hyperhomocysteinemia a predictive factor? an observational study

Lower limb amputation (LLA) is the drastic stage of peripheral arterial disease (PAD) where the hyperhomocysteinemia (H-HCY) seems to be a risk factor. Surprisingly, in literature the levels and the role of homocysteinemia (HCY) in persons with LLA are understudied. This study aims to investigate the level of HCY and its correlation with the functional outcomes after LLA.A case-control study to analyze HCY levels in amputees admitted in a rehabilitation hospital during an investigation period of 1.5 years. Barthel Index was used to assess the functional outcome.We enrolled 91 dysvascular amputees and 44 amputees for other reasons than PAD (controls). The mean level of HCY was found higher in dysvascular amputees (15.27.5) compared to controls (11.0 +/- 5.0, P&lt;0.0001) with a risk related ratio of 4.78. Normal Gaussian distribution of HCY was observed in controls, whereas in dysvascular amputees the data follow a double Gaussian distribution. Finally, a significant negative correlation was found between HCY and the effectiveness of rehabilitation (R=-0.37, P=0.001) only in dysvascular amputees.Dysvascular amputees had a level of HCY significantly higher than amputees without PAD. H-HCY seems to influence the functional outcomes of the rehabilitative treatment only in LLA due to PAD