Скелетная изомеризация гептанов в присутствии суперкислотных катализаторов различной природы

The sequence of the formation of multi-branched heptane isomers was studied in liquid and gaseous phases over different liquid and solid superacid catalysts. It was found that this sequence does not depend on the phase state, catalyst nature, and conditions, evidencing in favor of common reaction mechanism. The 2,4-dimethylpentane transformation into 2,2-dimethylpentane can be explained by the intermediate formation of cyclobutyl carbocation.Экспериментально изучена последовательность образования разветвленных изомеров при превращении н-гептана в жидкой и газовой фазах под действием различных жидких и твердого суперкислотных катализаторов. Найдено, что эта последовательность не зависит от фазового состояния, природы катализаторов и условий, что свидетельствует об общем механизме реакции. Превращение 2,4-диметилпентана в 2,2-диметилпентан можно объяснить промежуточным образованием циклобутильного карбкатиона

DNA repair, genome stability and cancer: a historical perspective

The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy

Skeletal isomerization of heptanes over superacid catalysts of different nature

The sequence of the formation of multi-branched heptane isomers was studied in liquid and gaseous phases over different liquid and solid superacid catalysts. It was found that this sequence does not depend on the phase state, catalyst nature, and conditions, evidencing in favor of common reaction mechanism. The 2,4-dimethylpentane transformation into 2,2-dimethylpentane can be explained by the intermediate formation of cyclobutyl carbocation