Historical and statistical data on the development of the domestic alcoholic beverages industry

The method of historical and statistical data analysis makes it possible to identify development and characteristic patterns, both temporary and permanent, production criteria for various branches of the food industry. The application of this method made it possible to trace formation of the alcohol industry inRussiaand identify critical historical events that influenced its development. The article presents and analyzes statistical data on the production of the main types of alcoholic beverages industry since 1913

Determination of ambiguity ellipse parameters at two dimensions using generalized method of uncertainty centre

Definition of empirical dependence parameters at two dimensions using ambiguity ellipse algorithm in a generalized method of uncertainty centre has been considered. The algorithm of optimal parameters definition is offere

Features of the immune status of patients with acute coronary syndrome who underwent СOVID-19, depending on the number of cytotoxic T lymphocytes (CD8⁺)

The 2019 coronavirus disease (COVID-19) pandemic has had an unprecedented impact on health and economies around the world. Direct myocardial injury and cytokine storm, leading to destabilization of preexisting plaques and accelerated formation of new plaques, are two mechanisms that trigger the acute coronary syndrome in COVID-19. There is insufficient data on the immune status of patients with acute coronary syndrome who have undergone COVID-19. The aim of the study was to study T and B cell, humoral immunity depending on the number of cytotoxic T lymphocytes (CD8+) in patients with acute coronary syndrome who underwent COVID-19. Materials and methods of research: 65 men with unstable angina pectoris and acute myocardial infarction (acute coronary syndrome) from 40 to 65 years old, who had previously had COVID-19, were examined. A study of peripheral blood was carried out: complete blood count (Medonic device, Sweden), general and specific IgM, IgG, IgA, compliment fragments (Vector Best, Russia). Subpopulations of T and B lymphocytes were determined by flow cytometry. In persons with acute coronary syndrome who underwent COVID-19 with predominantly normal and elevated levels of cytotoxic T cells, a more severe course of the disease was observed: patients with acute myocardial infarction prevailed, they had longer mortality, longer treatment duration, and stent thrombosis was more common. In patients with elevated cytotoxic T cells, there was a maximum increase in erythrocytes, hemoglobin, hematocrit, lymphocytes of both the total number and subpopulations – T helpers, T-NK lymphocytes, NK lymphocytes, T lymphocytes of early and late activation, B1 and B2 lymphocytes, index of NBT-induced test. In patients with normal levels of NK cells, compared with other groups, there was an increase in spontaneous NBT activity and index, a significant decrease in C3a and C5a complement fragments. Prevalence of stent thrombosis and mortality in the group of patients with normal levels of cytotoxic T cells may indicate torpidity of the immune system in these patients with poor outcomes

Modern Paradigms of Legal Understanding and the Development of Legal Consciousness in Supply Chain (Case Study of Russia)

This paper deals with the problem of the development of legal consciousness in supply chain of modern Russia amid the conceptual crisis of legal understanding in Russian law. The objective of the presented paper is to analyze modern paradigms of legal understanding and vectors of their development, as well as the influence of legal understanding on the development of legal consciousness in supply chain of Russia. The authors consider the current state of legal awareness in Russia. The choice of the topic is due to the existing theoretical discussion on the relationship between law, society and the state in supply chain of Russia

Concurrent thermochemoradiotherapy for brain high-grade glioma

Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards the increase in disease-free survival in the patients with newly diagnosed malignant gliomas

ПРИЧИНЫ РУБЦОВЫХ СТЕНОЗОВ ГОРТАНИ

There is the retrospective analysis of cicatrical laryngeal stenosis causes in the patients who were treated in the ENT Department First Pavlov State Medical University of St. Petersburg from 1992 to 2003 and from 2003 to 2013.Проведен ретроспективный анализ причин развития рубцового стеноза гортани среди больных, находившихся на лечении в клинике оториноларингологии ПСПбГМУ им. акад. И.П. Павлова в период с 1992 по 2003 г. и в период с 2003 по 2013 г

Russian gas companies’ financial strategy considering sustainable growth

Over the past ten years, an ambiguous situation concerning Russian gas companies has been observed. On the one hand, companies’ reports represent conservative policies and sustainable growth in the coming years. On the other hand, companies’ financial performance suggests another situation because of the insufficient level of financial indices that reflect the inconsistency of existing sustainable growth approaches. This situation indicates the relevance of the research concerning Russian gas companies’ financial sustainable growth in the conditions of the global economy, “economic sanctions” and investment policy implementation. The primary purpose of the research is to analyse Russian gas companies’ financial growth strategy employing Geniberg Z — matrix as well as enhanced financial sustainability indicators system indices by identifying which indicators have a greater influence on sustainable growth rate. We found that return on fixed assets ratio, net profit growth ratio, debt equity ratio influence on Russian gas companies’ sustainable growth rate and recommended for the system of financial sustainability indicators (FSIS) usage. We associate the concept of Russian gas companies’ financial sustainable growth with environmental protection, energy savings, and social factors. Thus, we added to the financial model non-financial factors. As a result of the analysis, we have obtained the dependence of Sustainable Growth Rate to Environmental Ratings as well as Return on social responsibility costs. We recommend paying more attention to the energy, social, environmental, and economic determinants that could contribute to sustainable growth. We also found that Russian gas market companies could improve Financial Strategies according to sustainable growth point of view. We suggest ways to enhance the financial strategy of Russian gas companies. © Steblyanskaya A., Wang Zh., Ryabova E. V., Razmanova S. V. Text. 2019

Water Microelement Composition Influence on the Efficiency of the Milk Powder Dissolution Process

Drinking water is important in food production. Its indicators have a direct impact on the quality and safety of finished products, the technological equipment efficiency, etc. In most food technologies, involving the use of milk powder, a priori use the process of its preliminary hydration, that is, dissolution or recovery. In this connection, there is a need to generalize the existing theoretical and practical foundations of this process and find ways to further improve them. Analysis of scientific and technical material in this area showed, that a number of scientists proposed various descriptions not only of individual stages, but also of the dissolution process as a whole, and its determining factors were identified, mathematical models were built, making it possible to determine critical areas depending on from the properties of the raw materials and the process, data were obtained on the parameters of the system during the dissolution of dry dairy products.In the article presents the sanitary and hygienic, physicochemical and organoleptic require-ments for drinking water by Russian legislation, international organizations and national standards of a number of countries.Presented a review of widely used and promising water treatment methods.Analyzed data, describing the effect of the microelement water composition on the efficiency of milk powder dissolving process. It is shown, that decrease of water total hardness and dry substances of mass fraction adjustment in the reconstituted milk have a positive effect on the dissolution process efficiency.Was noted the relevance of further researches on the directional formation of water trace ele-ment composition for increasing the efficiency of milk powder dissolving and to obtain re-constituted dairy systems, used in the production of various food products of predicted quality and safety.Drinking water is important in food production. Its indicators have a direct impact on the quality and safety of finished products, the technological equipment efficiency, etc. In most food technologies, involving the use of milk powder, a priori use the process of its preliminary hydration, that is, dissolution or recovery. In this connection, there is a need to generalize the existing theoretical and practical foundations of this process and find ways to further improve them. Analysis of scientific and technical material in this area showed, that a number of scientists proposed various descriptions not only of individual stages, but also of the dissolution process as a whole, and its determining factors were identified, mathematical models were built, making it possible to determine critical areas depending on from the properties of the raw materials and the process, data were obtained on the parameters of the system during the dissolution of dry dairy products.In the article presents the sanitary and hygienic, physicochemical and organoleptic require-ments for drinking water by Russian legislation, international organizations and national standards of a number of countries.Presented a review of widely used and promising water treatment methods.Analyzed data, describing the effect of the microelement water composition on the efficiency of milk powder dissolving process. It is shown, that decrease of water total hardness and dry substances of mass fraction adjustment in the reconstituted milk have a positive effect on the dissolution process efficiency.Was noted the relevance of further researches on the directional formation of water trace ele-ment composition for increasing the efficiency of milk powder dissolving and to obtain re-constituted dairy systems, used in the production of various food products of predicted quality and safety