Results of investigation of muon fluxes of superhigh energy cosmic rays with X-ray emulsion chambers

The overall data from the investigation of the cosmic ray muon flux in the range of zenith angles (0-90) deg within the energy range (3.5 to 5.0) TeV is presented. The exposure of large X-ray emulsion chambers underground was 1200 tons. year. The data were processe using the method which was applied in the experiment Pamir and differred from the earlier applied one. The obtained value of a slope power index of the differential energy spectrum of the global muon flux is =3.7 that corresponds to the slope of the pion generation differential spectrum, gamma sub PI = 2.75 + or - .04. The analysis of the muon zenith-angular distribution showed that the contribution of rapid generation muons in the total muon flux agree the best with the value .2% and less with .7% at a 90% reliability level

Pharmacological correction of immune disorders in patients with chronic heart failure and ischemic heart disease

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptor

Signal recognition and background suppression by matched filters and neural networks for Tunka-Rex

The Tunka Radio Extension (Tunka-Rex) is a digital antenna array, which measures the radio emission of the cosmic-ray air-showers in the frequency band of 30-80 MHz. Tunka-Rex is co-located with TAIGA experiment in Siberia and consists of 63 antennas, 57 of them are in a densely instrumented area of about 1 km\textsuperscript{2}. In the present work we discuss the improvements of the signal reconstruction applied for the Tunka-Rex. At the first stage we implemented matched filtering using averaged signals as template. The simulation study has shown that matched filtering allows one to decrease the threshold of signal detection and increase its purity. However, the maximum performance of matched filtering is achievable only in case of white noise, while in reality the noise is not fully random due to different reasons. To recognize hidden features of the noise and treat them, we decided to use convolutional neural network with autoencoder architecture. Taking the recorded trace as an input, the autoencoder returns denoised trace, i.e. removes all signal-unrelated amplitudes. We present the comparison between standard method of signal reconstruction, matched filtering and autoencoder, and discuss the prospects of application of neural networks for lowering the threshold of digital antenna arrays for cosmic-ray detection.Comment: ARENA2018 proceeding

Сравнительный анализ эффективности использования стоматологических препаратов для снижения гиперестезии зубов

Relevance. Many young patients suffer from dental abrasion combined with hyperesthesia of teeth. This pathology is to be treated complexly. The first stage of the treatment is aimed at decreasing the hypersensitivity. This problem is usually solved by dental therapist who can face a problem of a desensitizing agent selection.The objective was to evaluate the efficacy and convenience of using specific desensitizing agents at home in young patients with symptoms of hyperesthesia associated with generalized increased dental abrasion of the first degree of severity.Methods and materials. Patients suffering from generalized hyperesthesia caused by increased abrasion of hard tooth tissues have taken part in this research. The patients were treated with one of four selected desensitizing agents at home. The efficacy, financial side and the convenience of each product were evaluated by using the questionnaire. Also, the efficacy of the treatment was also evaluated clinically.Results. Clinical efficacy of the toothpaste containing arginine and gel with NaF (1.1 %) and gel based on nano-hydroxyapatite is approximately the same. The specific gel contained casein phosphopeptide-amorphous calcium phosphate is less effective.Conclusion. The gel based on the nano-hydroxyapatite is the most effective and convenient specialized product for the treatment of hyperesthesia in patients with increased dental abrasion.Введение. У молодых пациентов гиперестезия часто возникает на фоне повышенной стираемости зубов. Данное состояние требует комплексного подхода в лечении. Первой ступенью является терапия, направленная на снижение чувствительности зубов, которая назначается стоматологом-терапевтом. На этом этапе врач может столкнуться с проблемой выбора необходимых препаратов.Цель — оценить эффективность и удобство применения препаратов, применяемых для снижения симптомов гиперестезии в домашних условиях у молодых пациентов с симптомами гиперестезии, сопутствующей генерализованной повышенной стираемости зубов I степени тяжести.Методы и материалы. В исследовании принимали участие пациенты с генерализованной гиперестезией на фоне повышенной стираемости твердых тканей зубов. Пациентам был назначен 1 из 4 препаратов для снижения симптомов гиперестезии в домашних условиях. Эффективность и удобство лечения оценивали методом анкетирования. Эффективность препаратов оценивали также клинически.Результаты. Зубная паста с аргинином, гель на основе фторида натрия 1,1 %-го и гель с добавлением наногидроксиапатита дают приблизительно одинаковый клинический эффект. Препарат на основе казеина фосфопептида уступает вышеперечисленным аппаратам в эффективности.Выводы. Наиболее эффективным и удобным специализированным препаратом для лечения гиперестезии у пациентов на фоне повышенной стираемости зубов является гель с добавлением наногидроксиапатита

Current Status and New Challenges of The Tunka Radio Extension

The Tunka Radio Extension (Tunka-Rex) is an antenna array spread over an area of about 1~km$^2$. The array is placed at the Tunka Advanced Instrument for cosmic rays and Gamma Astronomy (TAIGA) and detects the radio emission of air showers in the band of 30 to 80~MHz. During the last years it was shown that a sparse array such as Tunka-Rex is capable of reconstructing the parameters of the primary particle as accurate as the modern instruments. Based on these results we continue developing our data analysis. Our next goal is the reconstruction of cosmic-ray energy spectrum observed only by a radio instrument. Taking a step towards it, we develop a model of aperture of our instrument and test it against hybrid TAIGA observations and Monte-Carlo simulations. In the present work we give an overview of the current status and results for the last five years of operation of Tunka-Rex and discuss prospects of the cosmic-ray energy estimation with sparse radio arrays.Comment: Proceedings of E+CRS 201

Improved measurements of the energy and shower maximum of cosmic rays with Tunka-Rex

The Tunka Radio Extension (Tunka-Rex) is an array of 63 antennas located in the Tunka Valley, Siberia. It detects radio pulses in the 30-80 MHz band produced during the air-shower development. As shown by Tunka-Rex, a sparse radio array with about 200 m spacing is able to reconstruct the energy and the depth of the shower maximum with satisfactory precision using simple methods based on parameters of the lateral distribution of amplitudes. The LOFAR experiment has shown that a sophisticated treatment of all individually measured amplitudes of a dense antenna array can make the precision comparable with the resolution of existing optical techniques. We develop these ideas further and present a method based on the treatment of time series of measured signals, i.e. each antenna station provides several points (trace) instead of a single one (amplitude or power). We use the measured shower axis and energy as input for CoREAS simulations: for each measured event we simulate a set of air-showers with proton, helium, nitrogen and iron as primary particle (each primary is simulated about ten times to cover fluctuations in the shower maximum due to the first interaction). Simulated radio pulses are processed with the Tunka-Rex detector response and convoluted with the measured signals. A likelihood fit determines how well the simulated event fits to the measured one. The positions of the shower maxima are defined from the distribution of chi-square values of these fits. When using this improved method instead of the standard one, firstly, the shower maximum of more events can be reconstructed, secondly, the resolution is increased. The performance of the method is demonstrated on the data acquired by the Tunka-Rex detector in 2012-2014.Comment: Proceedings of the 35th ICRC 2017, Busan, Kore

Tunka-Rex: energy reconstruction with a single antenna station (ARENA 2016)

The Tunka-Radio extension (Tunka-Rex) is a radio detector for air showers in Siberia. From 2012 to 2014, Tunka-Rex operated exclusively together with its host experiment, the air-Cherenkov array Tunka-133, which provided trigger, data acquisition, and an independent air-shower reconstruction. It was shown that the air-shower energy can be reconstructed by Tunka-Rex with a precision of 15\% for events with signal in at least 3 antennas, using the radio amplitude at a distance of 120\,m from the shower axis as an energy estimator. Using the reconstruction from the host experiment Tunka-133 for the air-shower geometry (shower core and direction), the energy estimator can in principle already be obtained with measurements from a single antenna, close to the reference distance. We present a method for event selection and energy reconstruction, requiring only one antenna, and achieving a precision of about 20\%. This method increases the effective detector area and lowers thresholds for zenith angle and energy, resulting in three times more events than in the standard reconstruction

First analysis of inclined air showers detected by Tunka-Rex

The Tunka Radio Extension (Tunka-Rex) is a digital antenna array for the detection of radio emission from cosmic-ray air showers in the frequency band of 30 to 80 MHz and for primary energies above 100 PeV. The standard analysis of Tunka-Rex includes events with zenith angle of up to 50$^\circ$. This cut is determined by the efficiency of the external trigger. However, due to the air-shower footprint increasing with zenith angle and due to the more efficient generation of radio emission (the magnetic field in the Tunka valley is almost vertical), there are a number of ultra-high-energy inclined events detected by Tunka-Rex. In this work we present a first analysis of a subset of inclined events detected by Tunka-Rex. We estimate the energies of the selected events and test the efficiency of Tunka-Rex antennas for detection of inclined air showers.Comment: ARENA2018 proceeding

Towards a cosmic-ray mass-composition study at Tunka Radio Extension (ARENA 2016)

The Tunka Radio Extension (Tunka-Rex) is a radio detector at the TAIGA facility located in Siberia nearby the southern tip of Lake Baikal. Tunka-Rex measures air-showers induced by high-energy cosmic rays, in particular, the lateral distribution of the radio pulses. The depth of the air-shower maximum, which statistically depends on the mass of the primary particle, is determined from the slope of the lateral distribution function (LDF). Using a model-independent approach, we have studied possible features of the one-dimensional slope method and tried to find improvements for the reconstruction of primary mass. To study the systematic uncertainties given by different primary particles, we have performed simulations using the CONEX and CoREAS software packages of the recently released CORSIKA v7.5 including the modern high-energy hadronic models QGSJet-II.04 and EPOS-LHC. The simulations have shown that the largest systematic uncertainty in the energy deposit is due to the unknown primary particle. Finally, we studied the relation between the polarization and the asymmetry of the LDF.Comment: ARENA proceedings, 4 pages, updated reference