Fairy tale traditions in amateur and professional young writers’ creativity

The turn of the 21st century has seen Russian writers’ increased interest in the genre of fairy tale. This paper discusses young Russian writers’ approaches to fairy tale traditions in texts of their own. The subjects of the study consisted of the Debut Prize winners and the so-called amateur writers (fans of Tolkien’s and Rowling’s books, and gamers) and their literary works. The study is aimed at establishing main trends in usage of folklore traditions in the first two decades of the 21st century; the paper is also concerned with examining similarities and differences between two generations of modern Russian writers in the matter of their approaches to classical heritage. To compare fairy tale texts, Vladimir Propp’s narrative model has been applied. One of the central claims of the study is that young authors tend to emulate literary samples by prominent contemporary Russian writers (mostly by Lyudmila Petrushevskaya). Thus, an efficient way of creating a contemporary fairy tale by a young author is to immerse its characters into the modern reality that is presented in a variety of its manifestations – from everyday routine to philosophic ideas. The young writers’ texts display such traditional features of literary folklorism as genuine fairy tale plots and motifs, their structural and style models, characters, magical objects, and the artistic device of estrangement

Space and time in the context of social measurement

This paper discusses some of the basic philosophical concepts – the concepts of “space and time” - and their relation to social evolution. The work presents the characteristics of social forms of space and time, shows the specifics of their formation in connection with human activity and the system of social relations. It was found that time duration has different manifestations in the context of historically different cultural epochs. Acceleration of social time takes place in the course of human historical practice development. Meanwhile, some social systems sometimes take the form of a certain deceleration in time. This usually occurs because of the inadequacy of the control system for the capabilities of the social organism. Social space is primarily connected with the dynamics of changes in social bonds and relationships. In the process of historical formation of social systems, social space assumes a more complex structure and expands. In the period of globalization growth, social space takes the form of a truly global integral system.peer-reviewe

Control system of parameters of the azimuthal module

Analytical and experimental studies of the azimuthal module of two-component vibrational micromechanical gyroscope were conducted. It is shown that the micromechanical gyroscope is a system with distributed parameters. The frequency analysis is performed using software T-Flex. The influence of mechanical disturbances on the movement of azimuthal module in the form of translational and angular oscillations is shown; the natural frequencies of the azimuth are defined

Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease

In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development. The role of morphogenic proteins of WNT signaling pathway in the cardiovascular pathology genesis is practically not clear. The research aim was a comprehensive study of the main proteins of WNT signaling pathway (β-catenin, sclerostin, GSK-3α, GSK-3β, WIF-1 and DVL-1) in the blood serum of 353 patients with coronary artery disease acute forms who were treated at the Orel regional vascular center from 2019 to 2021, and 50 healthy individuals. A comprehensive analysis included an assessment of clinical, laboratory and instrumental parameters in the framework of current clinical guidelines, as well as an immunological examination to determine the morphogenic proteins of WNT signaling by enzyme immunoassay. The results showed a wide variability in the values of morphogenic proteins of WNT signaling pathway in the patient’s blood serum. The levels of β-catenin, WIF-1 and DVL-1 significantly exceeded those obtained in healthy individuals, while the concentrations of sclerostin and GSK-3β did not differ significantly from them. The level of GSK-3α of patients was twice lower than in healthy individuals. The highest sclerostin concentrations were found in patients with existing calcification of the aortic valve leaflets and aortic walls. Acute coronary syndrome unfavorable course was observed in patients with both extremely high and extremely low WIF-1 levels. Significant correlations were established between the level of morphogenic proteins of WNT signaling pathway and lipid metabolism, as well as myocardial remodeling. The obtained data on changes in the protein production of WNT signaling pathway allow us to expand our understanding of the molecular aspects of the immunopathogenesis of myocardial remodeling in coronary artery disease, increase the predictive potential for cardiovascular disease diagnosis and determine the vector for further development of cardioimmunology determination

Control System of Parameters of the Azimuthal Module

Analytical and experimental studies of the azimuthal module of two-component vibrational micromechanical gyroscope were conducted. It is shown that the micromechanical gyroscope is a system with distributed parameters. The frequency analysis is performed using software T-Flex. The influence of mechanical disturbances on the movement of azimuthal module in the form of translational and angular oscillations is shown; the natural frequencies of the azimuth are defined

ROLE OF GSK-3 IN Wnt/β-CATENIN SIGNALING PATHWAY IN OBESITY

The complexity of the adipogenesis mechanism results from the impact of multiple cues, among which an important place is held by the components of the Wnt signaling pathway. The search for potential markers of the development of diseases related to obesity aroused an interest in the study of GSK-3 (glycogen synthase kinase), β-catenin. GSK-3β is an intracellular serine / threonine kinase found in the cytoplasm, nucleus, mitochondria, synthesized in all body tissues and involved in regulating metabolic processes, cell proliferation, apoptosis etc. The first of the discovered functions of GSK-3β was the regulation of glycogen synthesis. Active GSK-3β phosphorylates and thereby inhibits glycogen synthase. As a result of the insulin binding to the cell receptor via inositol-3-phosphate, protein kinase B (Akt1) is activated, which, in turn, phosphorylates and inhibits GSK-3β. In addition, GSK-3β is involved in the regulating glucose metabolism. The most important function of GSK-3β is the inhibition of the β-catenin protein. In a resting cell, GSK-3β in complex with the APC and Axin proteins binds and phosphorylates the β-catenin transcription factor, which leads to its ubiquitination and degradation. When Wnt proteins act on the cell, the Dvl protein is activated, which, by binding to GSK-3β, releases β-catenin, preventing its degradation, however, the role of GSK3α/β in the adipocyte inflammatory response has not yet been fully investigated, therefore it seems promising to study the role of GSK-3 in the Wnt/β-catenin signaling pathway in obesityThe aim of the study was to assess the activity of the components of the Wnt signaling pathway in obese patients by measuring the serum level of GSK-3 and β-catenin. There were enrolled 32 patients with progressive forms of I-III degree obesity in the absence of diabetes mellitus. The concentration of serum GSK-3α, GSK-3β, and β-catenin was measured by enzyme-linked immunoassay. Data are presented as absolute and relative (%) number of patients; arithmetic mean; medians, 1 and 3 quartiles – Ме (Q0.25-Q0.75). Obese patients contained a 7.5-fold increased serum level of GSK-3α (785 (371-1317.5) pg/ml) compared to healthy individuals 105 (102.5-110) pg/ml, (p < 0.001), paralleled with increased amount of GSK-3β, which level in obese patients was 295 (190-695) pg/ml, which is by 18.3% higher than those in healthy individuals 241 (218.75-287.5) pg/ml, p = 0.111. Amount of GSK-3 depending on the degree of obesity tended to increase, most often coupled to decreased β-catenin level which is consistent with the literature data and can be considered as a prognostic criterion for the course of pathological processes in obesity

Early stages of the evolution of chernozems under forest vegetation (Belgorod Oblast)

We studied automorphic forest-steppe Luvic and Haplic Chernozems (Siltic/Clayic, Pachic) of the southern part of the Central Russian Upland (Belgorod region), which were covered with broadleaved forest vegetation at different times (from 25 to 75 years ago). The studies were carried out on an overgrowing fallow and the adjacent maple-ash shelterbelt and on an area of growth of a natural oak forest towards the virgin meadow stepp

Characteristics of new cases of infiltrative pulmonary tuberculosis in patients having HIV infection with multidrug resistance of the pathogen according to multi-layer spiral computed tomography

Background. Identification of the characteristics of the pulmonary tuberculosis process using multi-layer spiral computed tomography (MSCT) in patients with tuberculosis and HIV infection is important in the diagnosis of tuberculosis, determining the dissemination of the process and its dynamics during treatment. The aim. To determine the initial characteristics and dynamics of infiltrative tuberculosis according to MSCT in patients with and without HIV infection, with and without multidrug resistance (MDR) of Mycobacterium tuberculosis who were treated in a hospital. Materials and methods. 126 patients aged 19–59 years with tuberculosis, combined with HIV infection and without HIV infection were examined. For statistical processing, we used MS Excel (Microsoft Corp., USA) software package. Results. Patients with tuberculosis and HIV infection in comparison with patients with tuberculosis and without HIV had more expressed intoxication syndrome and respiratory impairement in the clinical picture (p < 0.00001). Patients with coinfection were more likely to suffer from alcohol (p  <  0.05) and drug addiction (p < 0.001). According to MSCT, the pathological process in HIV-positive patients with pulmonary tuberculosis was more disseminated (p < 0.05), included severe intrathoracic lymphadenopathy (p < 0.0001), more common pleural lesions (p < 0.005), less common destructive changes (cavities) (p < 0.001) and outcomes in form of fibro-cavernous tuberculosis (p < 0.01). Process regression was slower in patients with tuberculosis and HIV (p < 0.005). According to MSCT, extensive lung damage, intrathoracic lymphadenopathy were  more often found in patients with MDR in coinfection (p  <  0.05). Cavities and fibro-cavernous tuberculosis outcomes were more common in patients with tuberculosis without HIV infection and with MDR (p < 0.05). Conclusion. MSCT provides detailed information about the pathological process in the lungs and its dynamics under the treatment of tuberculosis and HIV infection

Assessment of physical development of children with phenylketonuria

The aim of the study - to assess the level of physical development indicators in children with phenylketonuria in different age groups, to search for relationships between growth indicators and the level of hyperphenylalaninemia.Цель исследования – оценка уровня показателей физического развития у детей с фенилкетонурией в различных возрастных группах, поиск взаимосвязей между показателями роста и уровня гиперфенилаланинемии

The Toxic effects of the metals connected with changes of an immune profile of children from areas with raised technogenic loading of Sverdlovsk region

Results of inspection of 2096 children which lived in the territories carried to categories of risk on development of ecologically determined pathology Are presented. Children went on inspection and treatment after special selection taking into account a total rank on toxic loading, clinical indications. The estimation of efficiency of treatment included dynamics of the maintenance of heavy metals in blood. Results of clinic and laboratory researches were compared with made blood analyses on definition of concentration of heavy metals. The method has been applied to the analysis of interrelations of parameters of a homeostasis in comparison groups with use of F-criterion of communication. Considerable changes in immunity are formation basis pathologies of children from territories with bad ecology. Proofs of participation Pb. As, Си, Ni, Cr, Zn, Cd in formation of adverse factors of the anamnesis and a deviation of an immune profile of children are received. Efficiency of the spent treatment was accompanied by authentic decrease in concentration of heavy metals in blood of patients.Представлены результаты обследования 2096 детей, которые проживали на территориях, отнесённых к категориям риска по развитию экологически детерминированной патологии. Дети направлялись на обследование и лечение после специального отбора с учетом суммарного ранга по токсической нагрузке, клинических показаний. Оценка эффективности лечения включала динамику содержания тяжелых металлов в крови. Результаты клинико-лабораторных исследований сопоставлялись с данными анализов крови на определение концентрации тяжелых металлов. Для анализа взаимосвязей параметров гомеостаза в группах сравнения был применен метод с использованием F-критерия связи. Значительные нарушения в системе клеточного, гуморального иммунитета и системы фагоцитоза являются основой формирования полиорганной патологии у детей из экологически неблагополучных территорий. Получены доказательства участия Pb, As, Си, Ni, Сг, Zn, Cd в формировании неблагоприятных факторов анамнеза и отклонения иммунного профиля у детей. Эффективность проведённого лечения сопровождалась достоверным снижением концентрации тяжелых металлов в крови пациентов