Mineralogy in Geotechnical Engineering

The several investigations on soils by different researchers have been executed, but research on soil mechanical propertiesbased on mineralogy is very meager, in this regard the author intention is employee of natural minerals for evaluation of soilcohesion, it may leads to developments of a soil with appropriates characteristics in permeability, transmitting load, resistingagainst deformation and settlement. This paper deals with analysis of soil cohesion based on mineralogy. The result revealedcohesion of a plastic soil could be improve by mineral presented in an non plastic soil, and also carbonate has negative affecton soil cohesion and some other soil minerals also have same affect on cohesion that required to be more investigate

Localized modes in defective multilayer structures

In this paper, the localized surface modes in a defective multilayer structure has been investigated. It is shown that the defective multilayer structures can support two different kind of localized modes depending on the position and the thickness of the defect layer. One of these modes is localized at the interface between the multilayer structure and a homogeneous medium (the so-called surface mode) and the other one is localized at the defect layer (defect localized mode). We reveal that the presence of defect layer pushes the dispersion curve of surface modes to the lower or the upper edge of the photonic bandgap depending on the homogeneous medium is a left-handed or right-handed medium (e.g. vacuum), respectively. So, the existence region of the surface modes restricted. Moreover, the effect of defect on the energy flow velocity of the surface modes is discussed.Comment: 5 pages, 7 figure

Core promoter short tandem repeats as evolutionary switch codes for primate speciation

Alteration in gene expression levels underlies many of the phenotypic differences across species. Because of their highly mutable nature, proximity to the +1 transcription start site (TSS), and the emerging evidence of functional impact on gene expression, core promoter short tandem repeats (STRs) may be considered an ideal source of variation across species. In a genome-scale analysis of the entire Homo sapiens protein-coding genes, we have previously identified core promoters with at least one STR of ≥6-repeats, with possible selective advantage in this species. In the current study, we performed reverse analysis of the entire Homo sapiens orthologous genes in mouse in the Ensembl database, in order to identify conserved STRs that have shrunk as an evolutionary advantage to humans. Two protocols were used to minimize ascertainment bias. Firstly, two species sharing a more recent ancestor with Homo sapiens (i.e. Pan troglodytes and Gorilla gorilla gorilla) were also included in the study. Secondly, four non-primate species encompassing the major orders across Mammals, including Scandentia, Laurasiatheria, Afrotheria, and Xenarthra were analyzed as out-groups. We introduce STR evolutionary events specifically identical in primates (i.e. Homo sapiens, Pan troglodytes, and Gorilla gorilla gorilla) vs. non-primate out-groups. The average frequency of the identically shared STR motifs across those primates ranged between 0.00005 and 0.06. The identified genes are involved in important evolutionary and developmental processes, such as normal craniofacial development (TFAP2B), regulation of cell shape (PALMD), learning and long-term memory (RGS14), nervous system development (GFRA2), embryonic limb morphogenesis (PBX2), and forebrain development (APAF1). We provide evidence of core promoter STRs as evolutionary switch codes for primate speciation, and the first instance of identity-by-descent for those motifs at the interspecies level. © 2014 Wiley Periodicals, Inc

Theoretical study of dark resonances in micro-metric thin cells

We investigate theoretically dark resonance spectroscopy for a dilute atomic vapor confined in a thin (micro-metric) cell. We identify the physical parameters characterizing the spectra and study their influence. We focus on a Hanle-type situation, with an optical irradiation under normal incidence and resonant with the atomic transition. The dark resonance spectrum is predicted to combine broad wings with a sharp maximum at line-center, that can be singled out when detecting a derivative of the dark resonance spectrum. This narrow signal derivative, shown to broaden only sub-linearly with the cell length, is a signature of the contribution of atoms slow enough to fly between the cell windows in a time as long as the characteristic ground state optical pumping time. We suggest that this dark resonance spectroscopy in micro-metric thin cells could be a suitable tool for probing the effective velocity distribution in the thin cell arising from the atomic desorption processes, and notably to identify the limiting factors affecting desorption under a grazing incidence.Comment: 12 pages, 11 figures theoretical articl

Circular RNAs in cancer: New insights into functions and implications in ovarian cancer

Circular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse RNA molecules with a range of activities such as translation and splicing regulation, which are able to interacting with RNA-binding proteins and specially miRNA sponge. The expression patterns of the circRNAs exhibited tissue specificity and also, step and stage specificity. Accumulating evidences approved the critical role of circular RNAs in many cancers such as ovarian cancer. Given that these molecules exert their effects through multiple cellular and molecular mechanisms (i.e., angiogenesis, apoptosis, growth, and metastasis) which are involved in cancer pathogenesis, circular RNAs, in particular, act by controlling cell proliferation in ovarian cancer, so that, it has been shown that the deregulation of these molecules is associated with initiation and progression of ovarian cancer. Therefore, they are attractive molecules which have introduced them as cancer biomarkers. Moreover, they could be used as new therapeutic candidates for developing novel treatment strategies. Here, for first time, we have provided a comprehensive review on the recent knowledge of circular RNAs and their pathological roles in the ovarian cancer. © 2019 The Author(s)

Regional myocardial ischemia in hypertrophic cardiomyopathy: Impact of myectomy

AbstractObjectiveChest pain is a common finding in patients with hypertrophic cardiomyopathy and can be observed in 40% to 50% of all patients. However, the pathogenesis of these ischemia-like symptoms is still unclear.MethodsTwenty-two patients with hypertrophic cardiomyopathy and 15 controls underwent positron emission tomography for evaluation of regional myocardial perfusion and coronary flow reserve (hyperemic/baseline myocardial blood flow). Myocardial perfusion (mL/min/g) was measured using [13N]ammonia at rest and during hyperemia with dipyridamole (0.56 mg/kg intravenously). Regional coronary flow reserve was assessed in 3 planes (apical, midventricular, basal) in 4 regions (septal, anterior, lateral, inferior). Patients were divided into 2 groups: group 1 consisted of 11 patients treated with surgical myectomy (age 56 ± 10 years) and group 2 consisted of 11 patients treated medically (age 53 ± 13 years).ResultsMean global coronary flow reserve was 3.87 ± 0.92 in controls but 2.31 ± 0.40 in operated (P < .001 vs controls) and 1.76 ± 0.58 in medically treated patients (P < .001 vs controls, P < .05 vs operated). Similarly, septal coronary flow reserve was 4.19 ± 1.22 in controls but significantly reduced in operated patients (2.26 ± 0.48, P < .001 vs controls) and in medically treated patients (1.76 ± 0.58; P < .001 vs controls). However, septal flow reserve was significantly higher in operated patients than in patients with medically treated hypertrophic cardiomyopathy (+37%, P < .05), mainly due to a reduced resting myocardial perfusion.ConclusionsGlobal and regional myocardial perfusion is reduced in patients with hypertrophic cardiomyopathy. However, myectomy may have a beneficial effect on septal perfusion and flow reserve. Thus, ischemia seems to play an important role in the symptomatology and pathophysiology of hypertrophic cardiomyopathy

The Dirichlet Casimir effect for ϕ4\phi^4 theory in (3+1) dimensions: A new renormalization approach

We calculate the next to the leading order Casimir effect for a real scalar field, within $\phi^4$ theory, confined between two parallel plates in three spatial dimensions with the Dirichlet boundary condition. In this paper we introduce a systematic perturbation expansion in which the counterterms automatically turn out to be consistent with the boundary conditions. This will inevitably lead to nontrivial position dependence for physical quantities, as a manifestation of the breaking of the translational invariance. This is in contrast to the usual usage of the counterterms in problems with nontrivial boundary conditions, which are either completely derived from the free cases or at most supplemented with the addition of counterterms only at the boundaries. Our results for the massive and massless cases are different from those reported elsewhere. Secondly, and probably less importantly, we use a supplementary renormalization procedure, which makes the usage of any analytic continuation techniques unnecessary.Comment: JHEP3 format,20 pages, 2 figures, to appear in JHE