Clinical case of de novo anaplastic ganglioglioma and current status of the problem

The authors report a rare case of de novo malignant ganglioglioma (WHO grade III) in a 26-year old female. The patient has complained of periodic feeling fear, anxiety, episodes of impaired consciousness with extremity muscle cramps sometimes followed by urination, as well as flashes before eyes. Computed tomography perfusion and magnetic resonance spectroscopy were carried out for differential diagnosis between different types of tumors. Stereotactic biopsy was performed for histological examination. High surgical risk became a contraindication to gross total resection of the tumor. The patient has received radiation therapy (Trilogy linear accelerator) in a total dose of 60 Gy. The tumor shrank significantly. In 7 months, monitoring MRT did not detect further growth of the tumor. The authors have analyzed the case and reviewed the existing literature data regarding gangliogliomas. Taking into account low prevalence of these tumors (0.4-1% of all brain tumors), especially of their malignant forms (3-10% of gangliogliomas), lack of sufficient data regarding prognostic factors, life expectancy, time of recurrence, lack of accurate indications for different methods of treatment (surgery, radiation, chemotherapy), these tumors still need further research that should also involve supplementary neuroimaging techniques and stereotactic biopsy

Ethanol reforming in non-equilibrium plasma of glow discharge

The results of a detailed kinetic study of the main plasma chemical processes in non-equilibrium ethanol/argon plasma are presented. It is shown that at the beginning of the discharge the molecular hydrogen is mainly generated in the reaction of ethanol H-abstraction. Later hydrogen is formed from active H, CH2OH and CH3CHOH and formaldehyde. Comparison with experimental data has shown that the used kinetic mechanism predicts well the concentrations of main species at the reactor outlet.Comment: 16 pages, 8 figure

Diazepinone effect on liver tissue respiration and serum lipid content in rats with a rotenone model of Parkinson’s disease

Parkinson’s disease (PD) is a chronic and progressive age-related neurodegenerative disorder. Accumulation of α-synuclein aggregates, oxidative stress, mitochondrial dysfunction and lipid metabolism disturbance are thought to be the key violations at PD pathogenesis. Despite long-time research the causes of PD occurrence are not yet clear. We investigated the influence of diazepinon, a new derivative of benzodiazepine, on liver tissue respiration (LTR), serum lipid content and behavioral parameters of rats with modeled PD induced by intraperitoneal injections of 2.0 mg/kg rotenone (ROT) within 28 days. LTR was assessed using the polarograph LP-9. Blood samples for biochemical analysis were collected from the inferior vena cava. The behavioral parameters of rats were studied by the open field test. We showed that in rats with ROT – induced PD the coefficient of liver oxygen consumption was decreased by 33.5% (P < 0.001), the serum content of phospholipids, cholesterol, cholesterol esters, free fatty acids and triglycerides was reduced by 21.4% (P < 0.001), 28.8% (P < 0.001), 26.8% (P < 0.001), 30.3% (P < 0.01) and 41.5% (P < 0.001) respectively and the motor disorders were detected. Diazepinone application resulted in a full recovery of LTR, serum concentration of phospholipids, partial recovery of serum free fatty acids and triglycerides content and significant improvement of motor behavior. However diazepinone did not affect the reduced concentration of cholesterol and cholesterol esters in the serum of rats with simulated PD

Оцінка якості життя нейрохірургічних хворих з больовим синдромом

No abstract. Необходимость стандартизации методических приемов оценки КЖ при БС способствовала разработке разнообразных шкал. Сегодня в мире применяют около 50 шкал боли, самые известные из них представлены в предлагаемом обзоре.Без анотації

The first results of the trigeminal ganglion percutaneous balloon compression for trigeminal neuralgia treatment

The first experience of 8 patients with trigeminal neuralgia surgical treatment, using the method of trigeminal ganglion percutaneous balloon compression in the Meckel’s cave was presented. The details of technique and tools, necessary for this procedure were described. The early and remote results of treatment with this method appliance were analysed. The estimation of efficiency and prospects of percutaneous balloon compression appliance for resistant trigeminal neuralgia treatment were given

Teaching Russian to Non-Native Speaking Students in the Multicultural Space of Russian and Moldova Universities

The article gives a comparative analysis of the factors promoting an increase of interest in learning Russian on the part of non-native speaking students. The research is based on the survey of 225 students carried out at MGIMO-University and Chisinau State Pedagogical University (Moldova). The authors revealed linguo-didactic and sociocultural factors defining students’ choice of language of communication at the university and promoting the building of cognitive interest to learning Russian and forming intercultural competence. The research has shown that 1) the foreign bachelor’s and master’s students have clear goals in learning Russian; 2) the majority of students express an apparent interest in learning Russian; 3) most of students are interested in receiving skills in professional communication in Russian. The professional training of specialists in international relations implies knowing of several languages, the ability to work in multicultural environment, the readiness to effective cross-cultural communication. The research showed that it is necessary to make adjustments in the educational environment and the content of educational programmes based on the labour market demands

Дослідження проблем болю в літературі країн СНД

Medical literature on the pain problems in which the mechanisms of pain development, classification of pain types, methods of pain conservative and surgical treatment were studied, served as the basis of this review. The sources from the Institute scientific library include works, that have been published in countries of CIS for the last 5 years.В основу обзора положены данные специальной литературы по проблеме боли, отслежены основные тенденции в подходах к пониманию механизмов возникновения боли, разработке классификации типов боли, методам медикаментозного и хирургического лечения. Источники включают работы, опубликованные в течение последних 5 лет в литературе стран СНГ, которая имеется в научной библиотеке Института.В огляді літератури узагальнені результати досліджень протягом останніх 5 років з питань проблеми болю. Основну увагу приділено вивченню механізмів болю, класифікації типів болю, методів медикаментозного та хірургічного лікування. Джерела літератури використані з фонду наукової бібліотеки Інституту

The problem of pain investigation in the literature of CIS countries

Medical literature on the pain problems in which the mechanisms of pain development, classification of pain types, methods of pain conservative and surgical treatment were studied, served as the basis of this review. The sources from the Institute scientific library include works, that have been published in countries of CIS for the last 5 years

Molecular docking of nanosized titanium dioxide material to the extracellular part of GABAB-receptor

A spatial model of nanosized titanium dioxide material was created using Discovery Studio Visualizer software, versions 2.0 and 2.5. A search for and analysis of possible sites of its docking to the extracellular part of GABAB1а receptor subunit were performed using the algorythm for molecular docking PatchDock. The dimensions of the obtained ТіО2 nanoparticle surface were (18.925 × 3.785 × 19.028) Å. Four potentially possible sites of ТіО2 docking to the extracellular part of GABAB1а receptor subunit of GABAB were identified. The ТіО2 nanoparticle demonstrated high affinity of docking to one of the receptor sites with the geometric shape complementarity score of 12562, taking the following values in other sites: 10746; 10370; 10204. The approximate interface area of complex of the extracellular part of GABAB1а receptor subunit of GABAB with ТіО2 for the site with the highest geometric shape complementarity score was 1949.80 Å, and for others – 1273.20 Å, 1261.10 Å and 1170.30 Å, respectively. The evaluation of аtomic contact energy demonstrated the following values for the sites of ТіО2 nanoparticle docking: 362.92; 173.93; 340.63 and 224.61. The nature of connections, stabilizing the sites of ТіО2 docking to the extracellular part of GABAB1а receptor subunit of GABAB, was analyzed in accordance to their amino acid composition