Metodologia para melhorar a qualidade na organização do processo educacional através da implementação de software

The article deals with the issues of information exchange between teachers, pupils and educational organization departments. They analyzed the advantages and the disadvantages of traditional approaches: e-mail, communication via phones, social networks. They considered the issues of information placement intended for a large number of users. They revealed the need to address the problems associated with the publication of events - major administrative announcements of educational organizations, which are visible to all users and set to a certain date. The approach to publication of events is proposed within the framework of a system separate module. They considered the mechanism of mass mailings which allows users to transmit information to two or more recipients and ensures the exchange of information available only to recipients, unlike the "wall". An approach is proposed to increase the quality of the educational process organization, which allows a rapid exchange. The issues of information placement are considered on the website of the educational organization using the example of the training schedule. The advantages and the disadvantages of the traditional approach are analyzed. The issues of schedule planning among part-timer teachers are considered. They propose the approach to increase the quality the educational process quality organization, which allows you to place and make changes to the curriculum quickly using the example of the "Electronic Schedule" system.El artículo trata sobre los temas de intercambio de información entre profesores, alumnos y departamentos de organizaciones educativas. Analizaron las ventajas y desventajas de los enfoques tradicionales: correo electrónico, comunicación a través de teléfonos, redes sociales. Consideraron los problemas de la colocación de información destinados a un gran número de usuarios. Revelaron la necesidad de abordar los problemas asociados con la publicación de eventos: los principales anuncios administrativos de las organizaciones educativas, que son visibles para todos los usuarios y se establecen en una fecha determinada. El enfoque para la publicación de eventos se propone en el marco de un módulo separado del sistema. Consideraron el mecanismo de correo masivo que permite a los usuarios transmitir información a dos o más destinatarios y garantiza el intercambio de información disponible solo para los destinatarios, a diferencia del "muro". Se propone un enfoque para aumentar la calidad de la organización del proceso educativo, lo que permite un intercambio rápido. Los problemas de colocación de información se consideran en el sitio web de la organización educativa utilizando el ejemplo del programa de capacitación. Se analizan las ventajas y desventajas del enfoque tradicional. Se consideran los problemas de planificación de horarios entre los maestros a tiempo parcial. Proponen el enfoque para aumentar la calidad de la organización de la calidad del proceso educativo, lo que le permite ubicar y realizar cambios en el plan de estudios rápidamente utilizando el ejemplo del sistema "Programación electrónica".O artigo trata das questões de troca de informações entre professores, alunos e departamentos de organização educacional. Eles analisaram as vantagens e desvantagens das abordagens tradicionais: e-mail, comunicação via telefones, redes sociais. Eles consideraram os problemas de colocação de informações destinados a um grande número de usuários. Eles revelaram a necessidade de abordar os problemas associados à publicação de eventos - grandes anúncios administrativos de organizações educacionais, que são visíveis para todos os usuários e definidos para uma determinada data. A abordagem para publicação de eventos é proposta no âmbito de um módulo separado do sistema. Eles consideraram o mecanismo de envios em massa que permite aos usuários transmitir informações a dois ou mais destinatários e garante a troca de informações disponíveis apenas para os destinatários, ao contrário do "muro". Uma abordagem é proposta para aumentar a qualidade da organização do processo educacional, o que permite uma troca rápida. As questões de colocação de informações são consideradas no site da organização educacional usando o exemplo do cronograma de treinamento. As vantagens e desvantagens da abordagem tradicional são analisadas. As questões do planejamento do cronograma entre os professores temporários são consideradas. Eles propõem a abordagem para aumentar a qualidade da organização da qualidade do processo educacional, que permite colocar e fazer mudanças no currículo rapidamente usando o exemplo do sistema "Programação Eletrônica"

МЕТАБОЛИЧЕСКИЕ ЭФФЕКТЫ СУБСТРАТНОГО АНТИГИПОКСАНТА НА ОСНОВЕ ЯНТАРНОЙ КИСЛОТЫ

The paper discusses promises for clinical use of substrate antihypoxants.Objective: to investigate the efficacy of succinate containing  substrate  antihypoxants  on  systemic  oxygen  consumption,  blood  buffer  capacity,  and  changes  in  the  mixed venous blood level of lactate when they are used in gravely sick patients and victims with marked metabolic posthypoxic disorders.Subjects and methods. The trial enrolled 30 patients and victims who had sustained an episode of severe hypoxia of mixed genesis, the severity of which was evaluated by the APACHE II scale and amounted to 23 to 30 scores with a 46 to 70.3% risk of death. The standard infusion program in this group involved the succinate-containing drug 1.5% reamberin solution  in  a  total  dose  of  800  ml.  A  comparison  group  included  15  patients  who  had  undergone  emergency  extensive surgery for abdominal diseases. 400 ml of 10% glucose solution was used as an infusion medium. Oxygen consumption (VO2ml/min) and carbon dioxide production (VCO2ml/min) were measured before infusion and monitored for 2 hours. Arterial blood gases and acid-base balance (ABB) parameters and mixed venous blood lactate levels were examined. Measurements were made before and 30 minutes after the infusion of reamberin or glucose solution.Results. Infusion of 1.5% reamberin solution was followed by a significant increase in minute oxygen consumption from 281.5±21.2 to 310.4±24.4 ml/min. CO2 production declined (on average, from 223.3±6.5 to 206.5±7.59 ml/min). During infusion of 10% glucose solution, all the patients of the comparison group showed a rise in oxygen consumption from 303.6±33.86 to 443.13±32.1 ml/min, i.e. about 1.5-fold. VCO2 changed similarly. The intravenous infusion of 800 ml of 1.5% reamberin solution raised arterial blood buffer capacity, which was reflected by changes in pH, BE, and HCO3. There was a clear trend for lactate values to drop in the mixed venous blood. The intravenous injection of 400 ml of 10% glucose solution caused no significant changes in major ABB indicators, which reinforced the statement that there is a difference in the metabolism of these substrates.Conclusion. The succinate-containing drugs are able to compensate for metabolic acidosis. Their use is followed by increased oxygen consumption  and  activated  aerobic  oxidation  processes.  The  basis  of  their  antihypoxant  properties  was  thought  to  be recovered intracellular aerobic metabolic processes due to corrected intracellular metabolic acidosis and increased blood  buffer capacity.В статье обсуждаются перспективы клинического применения субстратных антигипоксантов.Цель — изучить влияние сукцинат-содержащих субстратных антигипоксантов на системное потребление кислорода, буферную емкость крови, динамику содержания в смешанной венозной крови лактата при их применении у тяжелобольных и пострадавших с выраженными метаболическими постгипоксическими нарушениями.Материалы и методы. В исследование включили 30 больных и пострадавших, перенесших эпизод тяжелой гипоксии смешанного генеза, тяжесть состояния которых оценивали по шкале APACHE II, она составила от 23 до 30 баллов с риском летального исхода от 46 до 70,3%. В состав стандартной инфузионной программы этой группы был включен сукцинат-содержащий препарат — реамберин 1,5% в суммарной дозе 800 мл. Группа сравнения (n=15) была представлена больными, которым в экстренном порядке выполняли обширные операции по поводу заболеваний органов брюшной полости. В качестве инфузионной среды был использован 10% раствор глюкозы в количестве 400 мл. До начала инфузии, а затем в мониторном режиме на протяжении двух часов измеряли потребление O2(VO2мл/мин) и выделение CO2(VCO2мл/мин). Изучался газовый состав, параметры КОС артериальной крови, содержание лактата в смешанной венозной крови. Измерения проводили до начала инфузии раствора реамберина или глюкозы, а также через 30 минут после ее завершения.Результаты. Инфузия  1,5%  раствора  реамберина  сопровождалась  достоверным  увеличением минутного  потребления  кислорода  с 281,5±21,2 мл/мин до 310,4±24,4 мл/мин. Выделение CO2 при этом снизилось (в среднем с 223,3±6,5 до 206,5±7,59 мл/мин). У всех больных группы сравнения во время инфузии 10% раствора глюкозы наблюдали увеличение потребления кислорода с 303,6±33,86 до 443,13±32,1 мл/мин, то есть почти в 1,5 раза. Аналогичным образом изменилосьVCO2. Внутривенная инфузия 800 мл 1,5% раствора реамберина повышала буферную емкость артериальной крови, что проявлялось изменением PH, BE и HCO3. Отмечали явную тенденцию к снижению содержания лактата в смешанной венозной крови. При внутривенном введении 400 мл 10% раствора глюкозы достоверных изменений основных показателей КОС не отмечали, что подтверждает предположение о различии в метаболизме этих субстратов.Заключение.  Препараты,  содержащие  в  своем  составе  сукцинат,  способны  компенсировать  метаболический  ацидоз.  Их применение сопровождается увеличением потребления кислорода и активацией процессов аэробного окисления. Полагаем, что основу их антигипоксантных качеств составляет восстановление процессов внутриклеточного аэробного метаболизма благодаря коррекции внутриклеточного метаболического ацидоза и увеличения буферной емкости крови.

The problem of acute kidney injury in the neonatal period. Literary review

The article presents the results of a literature search for publications and other available sources reflecting the state of the problem of acute kidney injury (AKI) in newborns. The issues of epidemiology, risk factors, and diagnosis were discussed in detail. Special attention is paid to the long-term prognosis of kidney function.В статье представлены результаты литературного поиска публикаций и других доступных источников, отражающих состояние проблемы острого почечного повреждения (ОПП) у новорождённых. Подробно были рассмотрены вопросы эпидемиологии, факторов риска и диагностики. Отдельное внимание уделено изучению отдалённого прогноза функции поче

Influence of sodium desoxyribonucleate on anti-infectious protection and hematopoiesis in patients with polytrauma (randomized prospective, double-blind, placebo-controlled study)

The  aim of the study was to evaluate  the effect of sodium  deoxyribonucleate on anti-infectious resistance and hematopoiesis in patients with polytraumas. A single-center study of sodium  deoxyribonucleate effectiveness approved by the local Ethics Committee (protocol No. 4 05/18/2016), was conducted in 54 patients with polytrauma. The  main  group  included 27 people, at the mean  age of 39 (29-51)  years old; ISS severity score,  26 (22-34). The  comparison group  comprised 27 people, mean  age,  40 years old (26-53), mean  ISS severity score was 25 points (20 to 29). The patients with randomly attributed even numbers were injected with 5 ml preparation from vials of even-numbered series, the patients with odd numbers were treated with preparation from the odd-numbered series. They were injected intramuscularly daily from day 1 to day 10 after the injury. Before treatment, as well as on days 8, 15 after injury, peripheral blood was examined for leukocyte, erythrocyte counts, hemoglobin, total  protein, blood  IL-6, CRP; proportion of CD117+  and  CD34+  mononuclear cells, CD14+ monocytes, CD14+ granulocytes, HLA-DR+  mononuclear cells, defensin + granulocytes.On  the  day  +8,   patients from  the  main  group,  against  the  comparison group  showed  an  increase   in lymphocytes, monocytes, CD117+ and CD34+ cell counts. Serum IL-6 and CRP were decreased in both groups of the patients to a similar  degree. Terms  of hospitalization in the main  group were 32.8 days, against  39.6 in comparison group. The number of complications per 1 case was, respectively, 21 versus 39, thus being 1.8 times less than  in comparison group.  When developing complications, anemia (Hb  < 90 g/l),  or hypoproteinaemia (< 60 g/l) in the main group was, respectively, 2.5and 3.5-fold  less than  in the comparison group.Treatment with sodium  deoxyribonucleate in polytrauma may promote migration of blood precursors to the bloodstream, increase anti-infectious properties of leukocytes, reduce duration of anemia and hypoproteinemia, number of complications and decrease the terms of hospitalization

Взаимодействие хлорокомплексов родия(III) с формальдегидом в сульфатно-хлоридных растворах.

Interaction of Rhodium(III) Chloride complexes with Formaldehyde into the sulphate and chloric solutions has been studied. Probably stages of reducing process that proceeds with metal Rhodium formation has been suggested. Influence of initial Rhodium, Formaldehyde and Hydrochloric acid concentration on the rate of each stage and on the extraction extent of valuable metal into a solid phase has been observed.Изучено взаимодействие хлорокомплексов родия(III) с формальдегидом в сульфатнохлоридных растворах. Предложены вероятные стадии процесса восстановления, протекающего с образованием родия металлического. Прослежено влияние начальной концентрации родия, формальдегида и соляной кислоты на скорость каждой из стадий и степень извлечения ценного металла в твердую фазу

A case report of surgical treatment of amiodarone-induced thyrotoxicosis in a patient with multiple organ failure

Amiodarone is a drug used in the treatment of life-threatening arrhythmias, which can lead to the development of amiodarone-induced thyrotoxicosis. In most cases this pathology can be treated by conservative methods; surgical treatment is resorted to in cases of thyrotoxicosis refractory to medical treatment. This case report describes surgical treatment of a patient with amiodarone-induced thyrotoxicosis, progressive heart failure, neurological pathology, bilateral pneumonia, functioning tracheostomy, systemic infectious process, multiple organ dysfunction syndrome, who was treated in the intensive care unit. Due to the lack of response to therapy with antithyroid drugs (thiamazole, lithium preparations and pulse therapy with prednisolone) and a progressive deterioration of the condition in a short period of time, according to vital indicators, the patient underwent thyroidectomy. In the postoperative period, there was a decrease in the occurrence of chronic heart failure symptoms. Medical control of cardiac arrhythmias was achieved. Surgical stage proceeded without complications in the period of 30-days. The patient was discharged for outpatient rehabilitation treatment

Neonatal sepsis: outcomes and long-term prognosis

The article presents the results of a comparative retrospective study of premature babies, with and without a neonatal sepsis. We studied the main patterns of morbidity in children in the first month after birth and the dynamics of health status by the age of 12 months. Retinopathy and pathology of the immune system are more common in premature babies with a neonatal sepsis at the age of 12 months, which requires special monitoring by narrow specialistВ статье представлены результаты сравнительного ретроспективного обследования детей, родившихся недоношенными. У половины пациентов в анамнезе был неонатальный сепсис. Группу сравнения составили дети с неотягощённым анамнезом по данной патологии. Были изучены основные закономерности заболеваемости детей в первый месяц после рождения и динамика состояния здоровья на протяжении первого года жизни. У недоношенных детей, имеющих в анамнезе неонатальный сепсис, в возрасте 12 месяцев чаще встречалась ретинопатия и патология иммунной системы, что требует особого наблюдения узкими специалистам