Genetic mechanisms of the influence of light and phototransduction on Drosophila melanogaster lifespan

The light of the visible spectrum (with wavelengths of 380-780 nm) is one of the fundamental abiotic factors to which organisms have been adapting since the start of biological evolution on the Earth. Numerous literature sources establish a connection between the duration of exposure to daylight, carcinogenesis and longevity, convincingly showing a significant reduction in the incidence of cancer in blind people, as well as in animal models. On the other hand, the stimulating nature of the effect of continuous illumination on reproductive function was noted, in particular, the effects of increasing the fecundity of females of various species are known. Increase in motor activity and, as a result, in metabolic rate and thermogenesis during permanent exposure to light also reduces the body's energy reserves and lifespan. In principle, in the context of aging, not only the exposure time, but also the age at the onset of exposure to constant illumination matter, the reverse effects are valid for the maintenance of experimental animals in the constant darkness. Over the long period of the evolution of light signal transduction systems, many mechanisms have emerged that allow to form an adequate response of the organism to illumination, modulating the highly conservative signaling cascades, including those associated with aging and lifespan (FOXO, SIRT1, NF-kB, mTOR/S6k, PPARa, etc). In this review, we consider the relationship between lifespan, photoregimens, and also the expression of the genes encoding the phototransduction cascade and the circadian oscillator elements of animal cells. In the present paper, basic transducers of light and other signals, such as the family of TRP receptors, G proteins, phospholipase C, and others, are considered in the context of aging and longevity. A relationship between the mechanisms of thermoreception, the temperature synchronization of the circadian oscillator and the life span is established in the review. Analysis of experimental data obtained from the Drosophila melano-gaster model allowed us to formulate the hypothesis of age-dependent photoresistance - a gradual decrease in the expression of genes associated with phototransduction and circadian oscillators, leading to deterioration in the ability to adapt to the photoregimen and to the increase in the rate of aging

Molecular CP-violating magnetic moment

A concept of CP-violating (T,P-odd) permanent molecular magnetic moments $\mu^{CP}$ is introduced. We relate the moments to the electric dipole moment of electron (eEDM) and estimate $\mu^{CP}$ for several diamagnetic polar molecules. The moments exhibit a steep, Z^5, scaling with the nuclear charge Z of the heavier molecular constituent. A measurement of the CP-violating magnetization of a polarized sample of heavy molecules may improve the present limit on eEDM by several orders of magnitude.Comment: 4 pages, no figures, submitted to PR

Association of C3435T (rs1045642) polymorphism of the MDR1 gene with the increased risk of colorectal cancer in russian females from Central Russia

The objective of this study was to examine associations of single nucleotide polymorphisms, rs1045642 within the MDR1 gene and rs1799930 within the NAT2 gene, with the risk of colorectal cancer (CRC) in the population of Central Russi

Genetics of aging and longevity

Lifespan is a complex quantitative characteristic that makes a significant contribution to the Darwinian adaptiveness. The disclosure of the genetic structure of longevity is a fundamental problem of the evolution of ontogeny, evolutionary genetics and molecular gerontology. Under optimal conditions, the lifespan is determined by the aging rate. The aging process is made up of interrelated processes that take place at the organismal, tissue, cellular, molecular and genetic levels. These include deregulation processes of homeostasis maintenance, metabolic reactions and sending intra- and intercellular signals, accumulation of senescent cells, damaged organelles and macromolecules, epigenetic changes and genetic instability. The objective of this review is to summarize the available information about underlying genetic determinants of longevity and aging. Genes and signaling pathways that regulate stress response, metabolism, growth of cells and organism, maintaining of genome and proteome integrity, qualitative and quantitative mitochondria composition, inflammatory response, apoptosis and selection of viable cells, as well as circadian rhythms were considered. The redistribution of energy resources from one pathway to the other can induce or inhibit the ”longevity program”, providing increased vitality and aging slowdown. Based on the analysis of geroprotective potential of examined genes’ regulation, main targets have been identified to slowdown aging and achieve healthy longevity. These trends include heterochromatin recovery, retrotransposition suppression, aneuploidy elimination; restoring the acidity of lysosomes; telomere elongation; suppression of chronic inflammation; elimination of protein cross-links; elimination of senescent cells; recovery of NAD+ levels; inhibition of mTOR, S6K, TGF-β, AT1; controlled activation of the ”longevity program” genes FOXO, AMPK, PGC1α, NRF2

Improving Josephson junction reproducibility for superconducting quantum circuits: junction area fluctuation

Josephson superconducting qubits and parametric amplifiers are prominent examples of superconducting quantum circuits that have shown rapid progress in recent years. With the growing complexity of such devices, the requirements for reproducibility of their electrical properties across a chip have become stricter. Thus, the critical current $I_c$ variation of the Josephson junction, as the most important electrical parameter, needs to be minimized. Critical current, in turn, is related to normal-state resistance the Ambegaokar-Baratoff formula, which can be measured at room temperature. Here, we focus on the dominant source of Josephson junction critical current non-uniformity junction area variation. We optimized Josephson junctions fabrication process and demonstrate resistance variation of $9.8-4.4\%$ and $4.8-2.3\%$ across $22{\times}22$ $mm^2$ and $5{\times}10$ $mm^2$ chip areas, respectively. For a wide range of junction areas from $0.008$ ${\mu}m^2$ to $0.12$ ${\mu}m^2$ we ensure a small linewidth standard deviation of $4$ $nm$ measured over 4500 junctions with linear dimensions from $80$ to $680$ $nm$. The developed process was tested on superconducting highly coherent transmon qubits $(T_1 > 100\:{\mu}s)$ and a nonlinear asymmetric inductive element parametric amplifier

High-Q trenched aluminum coplanar resonators with an ultrasonic edge microcutting for superconducting quantum devices

Dielectric losses are one of the key factors limiting the coherence of superconducting qubits. The impact of materials and fabrication steps on dielectric losses can be evaluated using coplanar waveguide (CPW) microwave resonators. Here, we report on superconducting CPW microwave resonators with internal quality factors systematically exceeding 5x106 at high powers and 2x106 (with the best value of 4.4x106) at low power. Such performance is demonstrated for 100-nm-thick aluminum resonators with 7-10.5 um center trace on high-resistivity silicon substrates commonly used in quantum Josephson junction circuits. We investigate internal quality factors of the resonators with both dry and wet aluminum etching, as well as deep and isotropic reactive ion etching of silicon substrate. Josephson junction compatible CPW resonators fabrication process with both airbridges and silicon substrate etching is proposed. Finally, we demonstrate the effect of airbridges positions and extra process steps on the overall dielectric losses. The best quality fa ctors are obtained for the wet etched aluminum resonators and isotropically removed substrate with the proposed ultrasonic metal edge microcutting.Comment: 6 pages, 2 figure

Broadband SNAIL parametric amplifier with microstrip impedance transformer

Josephson parametric amplifiers have emerged as a promising platform for quantum information processing and squeezed quantum states generation. Travelling wave and impedance-matched parametric amplifiers provide broad bandwidth for high-fidelity single-shot readout of multiple qubit superconducting circuits. Here, we present a quantum-limited 3-wave-mixing parametric amplifier based on superconducting nonlinear asymmetric inductive elements (SNAILs), whose useful bandwidth is enhanced with an on-chip two-section impedance-matching circuit based on microstrip transmission lines. The amplifier dynamic range is increased using an array of sixty-seven SNAILs with 268 Josephson junctions, forming a nonlinear quarter-wave resonator. Operating in a current-pumped mode, we experimentally demonstrate an average gain of $17 dB$ across $300 MHz$ bandwidth, along with an average saturation power of $- 100 dBm$, which can go as high as $- 97 dBm$ with quantum-limited noise performance. Moreover, the amplifier can be fabricated using a simple technology with just a one e-beam lithography step. Its central frequency is tuned over a several hundred megahertz, which in turn broadens the effective operational bandwidth to around $1.5 GHz$.Comment: 7 pages, 3 figure

(S)-2-Amino-2-(2-chloro­phen­yl)cyclo­hexa­none

The crystal structure of the title compound, C12H14ClNO, was determined in order to confirm that the chiral center of the mol­ecule has an S configuration. The cyclo­hexa­none ring adopts a chair conformation. The 2-chloro­phenyl ring is slightly twisted from the axial C—N bond, with a N—C—C—C torsion angle of −5.7 (2)°. In the crystal, an inter­molecular N—H⋯O hydrogen bond links adjacent mol­ecules into an infinite chain, which propagates in the b-axis direction

HYSTERESIS PROPERTIES AND MAGNETIZATION REVERSAL IN FeMn/FM (FM=Co, Fe, Ni, FeNi) FILMS WITH EXCHANGE BIAS

Angular dependencies of hysteresis properties of various ferromagnetic layers exchange coupled to a pinning antiferromagnetic layer have been investigated experimentally. The re-sults have been interpreted and analyzed in detail using macrospin approximation and micro-magnetic simulation.This work was supported by the Russian Science Foundation (project No 19-72-00141)