452 research outputs found
Applying Deweyan Principles to Global Citizenship Education in a Rural Context
Abstract Global citizenship education (GCE) helps students conceptualize citizenship beyond national boundaries so they are capable of action in dealing with global issues like human rights and environmental sustainability. However, very little literature exists to assist rural teachers in implementing GCE as they face specific challenges due to the context of their schools. This paper identifies challenges rural educators encounter, such as conservative communities and geographic isolation, and details a Deweyan approach to GCE as a means to overcome these challenges. Specifically, we apply Dewey’s democratic and social learning theories to reconceptualize GCE around student, family, and community life to foster a more relevant curriculum that utilizes students’ experiences (Dewey, 1897, 1902, 1938, 1916/2008). It emphasizes the utmost respect for local customs and culture by using them as sources of content for the curriculum while simultaneously extending citizenship thoughts and actions to the global arena.
Surface-enhanced Raman spectroscopy in 3D electrospun nanofiber mats coated with gold nanorods
Nanofibers functionalized by metal nanostructures and particles are exploited
as effective flexible substrates for SERS analysis. Their complex
three-dimensional structure may provide Raman signals enhanced by orders of
magnitude compared to untextured surfaces. Understanding the origin of such
improved performances is therefore very important for pushing nanofiber-based
analytical technologies to their upper limit. Here we report on polymer
nanofiber mats which can be exploited as substrates for enhancing the Raman
spectra of adsorbed probe molecules. The increased surface area and the
scattering of light in the nanofibrous system are individually analyzed as
mechanisms to enhance Raman scattering. The deposition of gold nanorods on the
fibers further amplifies Raman signals due to SERS. This study suggests that
Raman signals can be finely tuned in intensity and effectively enhanced in
nanofiber mats and arrays by properly tailoring the architecture, composition,
and light-scattering properties of the complex networks of filaments.Comment: 29 pages, 9 figures, 1 Tabl
Using Artificial Neural Networks for Gravitational-Wave Glitch Identification in Advanced LIGO
Control of photon transport properties in nanocomposite nanowires
Active nanowires and nanofibers can be realized by the electric-field induced
stretching of polymer solutions with sufficient molecular entanglements. The
resulting nanomaterials are attracting an increasing attention in view of their
application in a wide variety of fields, including optoelectronics, photonics,
energy harvesting, nanoelectronics, and microelectromechanical systems.
Realizing nanocomposite nanofibers is especially interesting in this respect.
In particular, methods suitable for embedding inorganic nanocrystals in
electrified jets and then in active fiber systems allow for controlling
light-scattering and refractive index properties in the realized fibrous
materials. We here report on the design, realization, and morphological and
spectroscopic characterization of new species of active, composite nanowires
and nanofibers for nanophotonics. We focus on the properties of
light-confinement and photon transport along the nanowire longitudinal axis,
and on how these depend on nanoparticle incorporation. Optical losses
mechanisms and their influence on device design and performances are also
presented and discussed.Comment: 7 pages, 3 figures, 29 references. Invited contribution. Copyright
(2016) Society of Photo Optical Instrumentation Engineers. One print or
electronic copy may be made for personal use only. Systematic reproduction
and distribution, duplication of any material in this paper for a fee or for
commercial purposes, or modification of the content of the paper are
prohibite
Threading Through Macrocycles Enhances the Performance of Carbon Nanotubes as Polymer Fillers
In this work we study the reinforcement of polymers by mechanically
interlocked derivatives of single-walled carbon nanotubes (SWNTs). We compare
the mechanical properties of fibers made of polymers and of composites with
pristine single-walled carbon nanotubes (SWNTs), mechanically interlocked
derivatives of SWNTs (MINTs) and the corresponding supramolecular models.
Improvements of both Young's modulus and tensile strength of up to 200 % were
observed for the polystyrene-MINTs samples with an optimized loading of just
0.01 wt.%, while the supramolecular models with identical chemical composition
and loading showed negligible or even detrimental influence. This behavior is
found for three different types of SWNTs and two types of macrocycles.
Molecular dynamics simulations show that the polymer adopts an elongated
conformation parallel to the SWNT when interacting with MINT fillers,
irrespective of the macrocycle chemical nature, whereas a more globular
structure is taken upon facing with either pristine SWNTs or supramolecular
models. The MINT composite architecture thus leads to a more efficient
exploitation of the axial properties of the SWNTs and of the polymer chain at
the interface, in agreement with experimental results. Our findings demonstrate
that the mechanical bond imparts distinctive advantageous properties to SWNT
derivatives as polymer fillers.Comment: 39 pages, 19 figure
Neuromodulatory effects of theta burst stimulation to the prefrontal cortex
Theta burst stimulation (TBS) is a new form of repetitive transcranial magnetic stimulation (TMS) capable of non-invasively modulating cortical excitability. In recent years TBS has been increasingly used as a neuroscientific investigative tool and therapeutic intervention for psychiatric disorders, in which the dorsolateral prefrontal cortex (DLPFC) is often the primary target. However, the neuromodulatory effects of TBS on prefrontal regions remain unclear. Here we share EEG and ECG recordings and structural MRI scans, including high-resolution DTI, from twenty-four healthy participants who received intermittent TBS (two sessions), continuous TBS (two sessions), and sham stimulation (one session) applied to the left DLPFC using a single-blinded crossover design. Each session includes eyes-open resting-state EEG and single-pulse TMS-EEG obtained before TBS and 2−, 15−, and 30-minutes post-stimulation. This dataset enables foundational basic science investigations into the neuromodulatory effects of TBS on the DLPFC
Sotagliflozin, the first dual SGLT inhibitor. Current outlook and perspectives
Sotagliflozin is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (T1D) and type 2 diabetes (T2D). Sotagliflozin inhibits renal sodium-glucose co-transporter 2 (determining significant excretion of glucose in the urine, in the same way as other, already available SGLT-2 selective inhibitors) and intestinal SGLT-1, delaying glucose absorption and therefore reducing post prandial glucose. Well-designed clinical trials, have shown that sotagliflozin (as monotherapy or add-on therapy to other anti-hyperglycemic agents) improves glycated hemoglobin in adults with T2D, with beneficial effects on bodyweight and blood pressure. Similar results have been obtained in adults with T1D treated with either continuous subcutaneous insulin infusion or multiple daily insulin injections, even after insulin optimization. A still ongoing phase 3 study is currently evaluating the effect of sotagliflozin on cardiovascular outcomes (ClinicalTrials.gov NCT03315143). In this review we illustrate the advantages and disadvantages of dual SGLT 2/1 inhibition, in order to better characterize and investigate its mechanisms of action and potentialities
Idiopathic sensorineural hearing loss is associated with endothelial dysfunction
Hearing impairment is the most prevalent sensory deficit [1].
Sensorineural hearing loss (SNHL) is the most common type of permanent
hearing loss and it occurswhen there is damage to the inner ear
(cochlea), or to the nerve pathways fromthe inner ear to the brain.Most
of the time, SNHL cannot be medically or surgically corrected.
SNHL can result from genetic, environmental, or combined etiologies
that prevent normal function of hearing, but, despite detailed investigation,
the main cause remains usually unknown. Clinical and experimental
studies have shown that ischemia contributes to several SNHL [2], suchas
sudden sensoneural hearing loss, presbyacusis and noise-induced hearing
loss. All of these SNHL can be related to alteration in blood flow [3].
The aim of the study is finding a relationship between idiopathic
SNHL and endothelial dysfunction
Change in Negative Affective Bias following a Single Ketamine Treatment for Treatment-Resistant Depression
Ketamine has recently emerged as a highly effective new treatment for people with treatment-resistant depression with rapid antidepressant effects. However, these effects are often short lasting, and the potential cognitive mechanisms underlying the therapeutic effects, such as effects on emotional processing bias, remain poorly understood. In the present study, we explored potential changes in emotional and cognitive processing following a single treatment of subcutaneous ketamine in a randomised double-blind controlled study with an active control. Participants with treatment-resistant major depressive disorder (MDD) were recruited from a single site from the Ketamine for Adult Depression Study (KADS Trial) and were randomly assigned to receive racemic ketamine hydrochloride (n=10) or midazolam hydrochloride (n=11) in a 1: 1 ratio. A healthy control sample (n=23) was recruited to attend a single experimental session without any treatment. All MDD participants completed mood ratings and cognitive assessments prior to and one day after a single randomised treatment. The results showed no significant differences in performance changes after treatment across the majority of emotion-related (i.e., Emotional Stroop Task, Affective Go/No-Go Task) and cognitive (Ruff 2 and 7 Selective Attention Test, Controlled Word Association Test) outcome measures. Participants who received ketamine showed a significant improvement in a negative processing bias test (i.e., The Scrambled Sentence Task; Cohen's d=.67, p=.016), which was not significantly associated with improvement in psychological symptoms (r=-.662, p=.074). The results from this exploratory study suggest that a single ketamine treatment may modulate negative affective bias. Limitations to this study included the small sample size and lack of follow-up. Future larger trials are required to confirm this finding
- …