Beyond naming patterns in children with WFDs: definitions for nouns and verbs

Children who experience difficulties in naming are described as having word finding difficulties (WFDs). In the present study 31 children with WFDs were identified through a wider survey of educational provision for those with language and communication difficulties. The children were included if they were between 6;4-7;10 years, had normal non-verbal intelligence, no major articulation difficulties and had WFDs as diagnosed by standard scores below 75 on Test of Word Finding Difficulties (TWF, German, 1989). Three control groups were identified who were matched on: chronological age (N = 31), naming age (N = 31) and level of receptive grammar (N = 31). Children?s accuracy of naming and latency to name were assessed for pictures of objects and actions. Children were asked to define the object and action terms at a later point. Children with WFDs were significantly less accurate in naming than their age matched peers but equivalent to that of the language matched peers. The group of children with WFDs were the slowest to accurately name all sets of items. All groups of children were less accurate in the provision of definitions for action terms than object terms. Overall the children with WFDs provided fewer accurate definitions than their chronological age matched peers. The nature of the children?s definitions indicated that they also differed from their language-matched peers. Particular difficulties were noted in the provision of semantic categorisation information. A range of standardised language assessments did not account for these difficulties. The findings are discussed in relation to the idea that WFDs are caused by impoverished semantic representations

Strong Purifying Selection at Synonymous Sites in D. melanogaster

Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation. We use site frequency spectra from deep population sequencing data to show that, contrary to this expectation, 22% of four-fold synonymous (4D) sites in D. melanogaster evolve under very strong selective constraint while few, if any, appear to be under weak constraint. Linking polymorphism with divergence data, we further find that the fraction of synonymous sites exposed to strong purifying selection is higher for those positions that show slower evolution on the Drosophila phylogeny. The function underlying the inferred strong constraint appears to be separate from splicing enhancers, nucleosome positioning, and the translational optimization generating canonical codon bias. The fraction of synonymous sites under strong constraint within a gene correlates well with gene expression, particularly in the mid-late embryo, pupae, and adult developmental stages. Genes enriched in strongly constrained synonymous sites tend to be particularly functionally important and are often involved in key developmental pathways. Given that the observed widespread constraint acting on synonymous sites is likely not limited to Drosophila, the role of synonymous sites in genetic disease and adaptation should be reevaluated

Development of a Work Control System for Propulsion Testing at NASA Stennis

In 1996 Stennis Space Center was given management authority for all Propulsion Testing for NASA. Over the next few years several research and development (R&D) test facilities were completed and brought up to full operation in what is known as the E-Complex Test Facility at Stennis Space Center. To construct, activate and operate these test facilities, a manual paper-based work control system was created. After utilizing this paper-based work control system for approximately three years, it became apparent that the research and development test area needed a better method to execute, monitor, and report on tasks required to further propulsion testing. The paper based system did not provide the engineers adequate visibility into work tasks or the tracking of testing or hardware discrepancies. This system also restricted the engineer s ability to utilize and access past knowledge and experiences given the severe schedule limitations for most R&D propulsion testing projects. Therefore a system was developed to meet the growing need of Test Operations called the Propulsion Test Directorate (PTD) Work Control System. This system is used to plan, perform, and track tasks that support testing and also to capture lessons learned while doing so

Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).

Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere. We therefore investigated contractile and regulatory proteins in left ventricular tissue from 25 cats, 18 diagnosed with HCM, including a Ragdoll cat with a homozygous MYBPC3 R820W, and 7 non-HCM cats in comparison with human HCM (from septal myectomy) and donor heart tissue. Myofibrillar protein expression was normal except that we observed 20–44% MyBP-C haploinsufficiency in 5 of the HCM cats. Troponin extracted from 8 HCM and 5 non-HCM cat hearts was incorporated into thin filaments and studied by in vitro motility assay. All HCM cat hearts had a higher (2.06 ± 0.13 fold) Ca2+-sensitivity than non-HCM cats and, in all the HCM cats, Ca2+-sensitivity was not modulated by troponin I phosphorylation. We were able to restore modulation of Ca2+-sensitivity by replacing troponin T with wild-type protein or by adding 100 μM Epigallocatechin 3-gallate (EGCG). These fundamental regulatory characteristics closely mimic those seen in human HCM indicating a common molecular mechanism that is independent of the causative mutation. Thus, the HCM cat is a potentially useful large animal model

Applying Optimization to the Conservation Project Selection Process: A Case Study of Readiness and Environmental Protection Initiative

This study presents a thorough discussion of the efficiency and effectiveness improvement from optimization models (Binary Linear Programming and Goal Programming), as applied to the Department of Defense’s Readiness and Environmental Protection Initiative. The OM models can yield 21% and 19.1% higher benefit scores respectively, spending $13,013,473 and$31,463,473 less total acquisition costs. To achieve the same level of conservation benefits for the current rank based approach, the REPI would spend additional $20.1 million and approximate 50% of the budget. A counterpart of OM- the cost-effective analysis is observed to be inefficient when the problem becomes complex. In a real world of political environment of the conservation programs, we suggest a hybrid method of current rank based approach and the OM as well as the GP to address incompatible goals of interests groups.Environmental Economics and Policy, C6, Q24,

Prediction of rainfall intensity measurement errors using commercial microwave communication links

Commercial microwave radio links forming cellular communication networks are known to be a valuable instrument for measuring near-surface rainfall. However, operational communication links are more uncertain relatively to the dedicated installations since their geometry and frequencies are optimized for high communication performance rather than observing rainfall. Quantification of the uncertainties for measurements that are non-optimal in the first place is essential to assure usability of the data. <br><br> In this work we address modeling of instrumental impairments, i.e. signal variability due to antenna wetting, baseline attenuation uncertainty and digital quantization, as well as environmental ones, i.e. variability of drop size distribution along a link affecting accuracy of path-averaged rainfall measurement and spatial variability of rainfall in the link's neighborhood affecting the accuracy of rainfall estimation out of the link path. Expressions for root mean squared error (RMSE) for estimates of path-averaged and point rainfall have been derived. To verify the RMSE expressions quantitatively, path-averaged measurements from 21 operational communication links in 12 different locations have been compared to records of five nearby rain gauges over three rainstorm events. <br><br> The experiments show that the prediction accuracy is above 90% for temporal accumulation less than 30 min and lowers for longer accumulation intervals. Spatial variability in the vicinity of the link, baseline attenuation uncertainty and, possibly, suboptimality of wet antenna attenuation model are the major sources of link-gauge discrepancies. In addition, the dependence of the optimal coefficients of a conventional wet antenna attenuation model on spatial rainfall variability and, accordingly, link length has been shown. <br><br> The expressions for RMSE of the path-averaged rainfall estimates can be useful for integration of measurements from multiple heterogeneous links into data assimilation algorithms

Ascertaining the Core Collapse Supernova Mechanism: An Emerging Picture?

Here we present the results from two sets of simulations, in two and three spatial dimensions. In two dimensions, the simulations include multifrequency flux-limited diffusion neutrino transport in the "ray-by-ray-plus" approximation, two-dimensional self gravity in the Newtonian limit, and nuclear burning through a 14-isotope alpha network. The three-dimensional simulations are model simulations constructed to reflect the post stellar core bounce conditions during neutrino shock reheating at the onset of explosion. They are hydrodynamics-only models that focus on critical aspects of the shock stability and dynamics and their impact on the supernova mechanism and explosion. In two dimensions, we obtain explosions (although in one case weak) for two progenitors (11 and 15 Solar mass models). Moreover, in both cases the explosion is initiated when the inner edge of the oxygen layer accretes through the shock. Thus, the shock is not revived while in the iron core, as previously discussed in the literature. The three-dimensional studies of the development of the stationary accretion shock instability (SASI) demonstrate the fundamentally new dynamics allowed when simulations are performed in three spatial dimensions. The predominant l=1 SASI mode gives way to a stable m=1 mode, which in turn has significant ramifications for the distribution of angular momentum in the region between the shock and proto-neutron star and, ultimately, for the spin of the remnant neutron star. Moreover, the three-dimensional simulations make clear, given the increased number of degrees of freedom, that two-dimensional models are severely limited by artificially imposed symmetries.Comment: 9 pages, 3 figure

Social Preferences and Voting: An Exploration Using a Novel Preference Revealing Mechanism

Public referenda are frequently used to determine the provision of public goods. As public programs have distributional consequences, a compelling question is what role if any social preferences have on voting behavior. This paper explores this issue using laboratory experiments wherein voting outcomes lead to a known distribution of net benefits across participants. Preferences are elicited using a novel Random Price Voting Mechanism (RPVM), which is a more parsimonious mechanism than dichotomous choice referenda, but gives consistent results. Results suggest that social preferences, in particular a social efficiency motive, lead to economically meaningful deviations from self-interested voting choices and increase the likelihood that welfare-enhancing programs are implemented.Institutional and Behavioral Economics, Research Methods/ Statistical Methods, C91, C92, D64, D72, H41,