Radiation environment along the INTEGRAL orbit measured with the IREM monitor

The INTEGRAL Radiation Environment Monitor (IREM) is a payload supporting instrument on board the INTEGRAL satellite. The monitor continually measures electron and proton fluxes along the orbit and provides this information to the spacecraft on board data handler. The mission alert system broadcasts it to the payload instruments enabling them to react accordingly to the current radiation level. Additionally, the IREM conducts its autonomous research mapping the Earth radiation environment for the space weather program. Its scientific data are available for further analysis almost without delay.Comment: 5 pages, 7 figures, accepted for publication in A+A letter

New estimates of pan-Arctic sea ice-atmosphere neutral drag coefficients from ICESat-2 elevation data

The effect that sea ice topography has on the momentum transfer between ice and atmosphere is not fully quantified due to the vast extent of the Arctic and limitations of current measurement techniques. Here we present a method to estimate pan-Arctic momentum transfer via a parameterization that links sea ice-atmosphere form drag coefficients with surface feature height and spacing. We measure these sea ice surface feature parameters using the Ice, Cloud and land Elevation Satellite-2 (ICESat-2). Though ICESat-2 is unable to resolve as well as airborne surveys, it has a higher along-track spatial resolution than other contemporary altimeter satellites. As some narrow obstacles are effectively smoothed out by the ICESat-2 ATL07 spatial resolution, we use near-coincident high-resolution Airborne Topographic Mapper (ATM) elevation data from NASA's Operation IceBridge (OIB) mission to scale up the regional ICESat-2 drag estimates. By also incorporating drag due to open water, floe edges and sea ice skin drag, we produced a time series of average total pan-Arctic neutral atmospheric drag coefficient estimates from November 2018 to May 2022. Here we have observed its temporal evolution to be unique and not directly tied to sea ice extent. By also mapping 3-month aggregates for the years 2019, 2020 and 2021 for better regional analysis, we found the thick multiyear ice area directly north of the Canadian Archipelago and Greenland to be consistently above 2.0×10-3, while most of the multiyear ice portion of the Arctic is typically around ∼1.5×10-3

Effect of Age at Diagnosis on Cervical Cancer Patient Prognoses in Georgia

The current incidence of cervical cancer varies around 17.0/100,000 women per year. The study aims to describe the effect of age at diagnosis on CC patient prognosis in Georgia. Methods. Univariable and Multivariable survival analysis using Cox’s regression model was constructed. All women aged ≤80 years,  diagnosed with invasive CC (ICD10-site code C53) from 2015 to 2019,  were eligible for inclusion in the analysis. During analysis a hazard (mortality) ratio for the patients, who were diagnosed at different ages was estimated. Survival period was determined from the date of diagnosis until the date of death or the date of last follow up visit. High risk of death was defined as a mortality of CC patients whose survival period was less than 5 years.The level of statistical significance of the study findings is estimated by using p-value andthe 95% of confidence interval (95%CI). A p value < 0.05 was considered as statistically significant. In estimation of hazard ratio, the patients under 41 years were selected as a reference group. Data was analyzed using Statistical Package of SPSS version 23. Results.Totally 1646 CC patients were enrolled in the study. The median age at diagnosis was 54years and age range was 25 - 80 years. Univariable statistical analysis has revealed that cancer diagnosed over 60 years of age had a higher death hazard (HR=1.80, p<0.001), compared to cancer detected under 60 years (HR=3.30, p<0.001). Multivariable statistical analysis has detected that stage and age at diagnosis are independent, statistically significant predictors for high mortality in patients diagnosed with cervical cancer, while the role of histological grade has not been revealed. In addition, older age generally is related to a high prevalence of comorbidities. The reasons for the unfavourable cervical cancer prognosis in older patients that was detected  during statistical analysis might be explained by tumor stage at diagnoses and with higher ratesof comorbidity among the elderly. Conclusions: Finally, our study results are in concordance with numerous studies, which confirm that the age of patients at the moment of diagnosis is an independent predictor for cervical cancer early mortality

Nonlinear dynamics of two coupled nano-electromechanical resonators

As a model of coupled nano-electromechanical resonantors we study two nonlinear driven oscillators with an arbitrary coupling strength between them. Analytical expressions are derived for the oscillation amplitudes as a function of the driving frequency and for the energy transfer rate between the two oscillators. The nonlinear restoring forces induce the expected nonlinear resonance structures in the amplitude-frequency characteristics with asymmetric resonance peaks. The corresponding multistable behavior is shown to be an efficient tool to control the energy transfer arising from the sensitive response to small changes in the driving frequency. Our results imply that the nonlinear response can be exploited to design precise sensors for mass or force detection experiments based on nano-electromechanical resonators.Comment: 19 pages, 2 figure

Chaotic Phenomenon in Nonlinear Gyrotropic Medium

Nonlinear gyrotropic medium is a medium, whose natural optical activity depends on the intensity of the incident light wave. The Kuhn's model is used to study nonlinear gyrotropic medium with great success. The Kuhn's model presents itself a model of nonlinear coupled oscillators. This article is devoted to the study of the Kuhn's nonlinear model. In the first paragraph of the paper we study classical dynamics in case of weak as well as strong nonlinearity. In case of week nonlinearity we have obtained the analytical solutions, which are in good agreement with the numerical solutions. In case of strong nonlinearity we have determined the values of those parameters for which chaos is formed in the system under study. The second paragraph of the paper refers to the question of the Kuhn's model integrability. It is shown, that at the certain values of the interaction potential this model is exactly integrable and under certain conditions it is reduced to so-called universal Hamiltonian. The third paragraph of the paper is devoted to quantum-mechanical consideration. It shows the possibility of stochastic absorption of external field energy by nonlinear gyrotropic medium. The last forth paragraph of the paper is devoted to generalization of the Kuhn's model for infinite chain of interacting oscillators

Two-step interphase microtubule disassembly aids spindle morphogenesis

Background Entry into mitosis triggers profound changes in cell shape and cytoskeletal organisation. Here, by studying microtubule remodelling in human flat mitotic cells, we identify a two-step process of interphase microtubule disassembly. Results First, a microtubule-stabilising protein, Ensconsin/MAP7, is inactivated in prophase as a consequence of its phosphorylation downstream of Cdk1/cyclin B. This leads to a reduction in interphase microtubule stability that may help to fuel the growth of centrosomally nucleated microtubules. The peripheral interphase microtubules that remain are then rapidly lost as the concentration of tubulin heterodimers falls following dissolution of the nuclear compartment boundary. Finally, we show that a failure to destabilise microtubules in prophase leads to the formation of microtubule clumps, which interfere with spindle assembly. Conclusions This analysis highlights the importance of the step-wise remodelling of the microtubule cytoskeleton and the significance of permeabilisation of the nuclear envelope in coordinating the changes in cellular organisation and biochemistry that accompany mitotic entry

New estimates of pan-Arctic sea ice–atmosphere neutral drag coefficients from ICESat-2 elevation data

The effect that sea ice topography has on the momentum transfer between ice and atmosphere is not fully quantified due to the vast extent of the Arctic and limitations of current measurement techniques. Here we present a method to estimate pan-Arctic momentum transfer via a parameterization that links sea ice–atmosphere form drag coefficients with surface feature height and spacing. We measure these sea ice surface feature parameters using the Ice, Cloud and land Elevation Satellite-2 (ICESat-2). Though ICESat-2 is unable to resolve as well as airborne surveys, it has a higher along-track spatial resolution than other contemporary altimeter satellites. As some narrow obstacles are effectively smoothed out by the ICESat-2 ATL07 spatial resolution, we use near-coincident high-resolution Airborne Topographic Mapper (ATM) elevation data from NASA's Operation IceBridge (OIB) mission to scale up the regional ICESat-2 drag estimates. By also incorporating drag due to open water, floe edges and sea ice skin drag, we produced a time series of average total pan-Arctic neutral atmospheric drag coefficient estimates from November 2018 to May 2022. Here we have observed its temporal evolution to be unique and not directly tied to sea ice extent. By also mapping 3-month aggregates for the years 2019, 2020 and 2021 for better regional analysis, we found the thick multiyear ice area directly north of the Canadian Archipelago and Greenland to be consistently above 2.0×10-3, while most of the multiyear ice portion of the Arctic is typically around ∼1.5×10-3.</p

Resonance-like coherent production of a pion pair in the reaction pd→pdππpd \rightarrow pd\pi\pi in the GeV region

The reaction $p + d \rightarrow p + d + X$ was studied at 0.8-2.0 GeV proton beam energies with the ANKE magnetic spectrometer at the COSY synchrotron storage ring. The proton-deuteron pairs emerging with high momenta, 0.6-1.8 GeV/$c$, were detected at small angles with respect to the proton beam. Distribution over the reaction missing mass $M_x$ reveals a local enhancement near the threshold of the pion pair production specific for the so-called ABC effect. The enhancement has a structure of a narrow bump placed above a smooth continuum. The invariant mass of the $d\pi\pi$ system in this enhancement region exhibits a resonance-like peak at $M_{d\pi\pi} \approx 2.36$ GeV/$c^2$ with the width $\Gamma \approx 0.10$ GeV/$c^2$. A possible interpretation of these features is discussed.Comment: 14 pages, 16 figures, submitted to Eur. Phys. J. A. v2: Added references [42,43] in section IV.A. v3: revised version according to referee remarks v4: revised version according to referee remark

Measurement of the analyzing powers in pd elastic and pn quasi-elastic scattering at small angles

The analyzing powers in proton-deuteron elastic and proton-neutron quasi-elastic scattering have been measured at small angles using a polarized proton beam at the COSY storage ring incident on an unpolarized deuterium target. The data were taken at 796MeV and five higher energies from 1600MeV to 2400MeV. The analyzing power in pd elastic scattering was studied by detecting the low energy recoil deuteron in telescopes placed symmetrically in the COSY plane to the left and right of the beam whereas for pn quasi-elastic scattering a low energy proton was registered in one of the telescopes in coincidence with a fast scattered proton measured in the ANKE magnetic spectrometer. Though the experiment explores new domains, the results are consistent with the limited published information.Comment: 10 pages with 8 figure