Fire extinguishment in oxygen enriched atmospheres

Current state-of-the-art of fire suppression and extinguishment techniques in oxygen enriched atmosphere is reviewed. Four classes of extinguishment action are considered: cooling, separation of reactants, dilution or removal of fuel, and use of chemically reactive agents. Current practice seems to show preference for very fast acting water spray applications to all interior surfaces of earth-based chambers. In space, reliance has been placed on fire prevention methods through the removal of ignition sources and use of nonflammable materials. Recommendations are made for further work related to fire suppression and extinguishment in oxygen enriched atmospheres, and an extensive bibliography is appended

On the Possibility of Tidal Formation of Binary Planets Around Ordinary Stars

The planet formation process and subsequent planet migration may lead to configurations resulting in strong dynamical interactions among the various planets. Well-studied possible outcomes include collisions between planets, scattering events that eject one or more of the planets, and a collision of one or more of the planets with the parent star. In this work we consider one other possibility that has seemingly been overlooked in the various scattering calculations presented in the literature: the tidal capture of two planets which leads to the formation of a binary planet (or binary brown dwarf) in orbit about the parent star. We carry out extensive numerical simulations of such dynamical and tidal interactions to explore the parameter space for the formation of such binary planets. We show that tidal formation of binary planets is possible for typical planet masses and distances from the host star. The detection (or lack thereof) of planet-planet binaries can thus be used to constrain the properties of planetary systems, including their mutual spacing during formation, and the fraction of close planets in very eccentric orbits which are believed to form by a closely related process.Comment: 11 pages, 10 Figures, submitted to Ap

Production of Millisecond Dips in Sco X-1 Count Rates by Dead Time Effects

Chang et al. (2006) reported millisecond duration dips in the X-ray intensity of Sco X-1 and attributed them to occultations of the source by small trans-Neptunian objects (TNOs). We have found multiple lines of evidence that these dips are not astronomical in origin, but rather the result of high-energy charged particle events in the RXTE PCA detectors. Our analysis of the RXTE data indicates that at most 10% of the observed dips in Sco X-1 could be due to occultations by TNOs, and, furthermore, we find no positive or supporting evidence for any of them being due to TNOs. We therefore believe that it is a mistake to conclude that any TNOs have been detected via occultation of Sco X-1.Comment: Submitted to ApJ; uses emulateapj.cls, 8 pages with 8 figure

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.

INTRODUCTION: Colorectal cancer remains the second leading cause of cancer death in the United States, and new strategies to prevent, detect, and treat the disease are needed. The receptor, guanylate cyclase C (GUCY2C), a tumor suppressor expressed by the intestinal epithelium, has emerged as a promising target. Areas covered: This review outlines the role of GUCY2C in tumorigenesis, and steps to translate GUCY2C-targeting schemes to the clinic. Endogenous GUCY2C-activating ligands disappear early in tumorigenesis, silencing its signaling axis and enabling transformation. Pre-clinical models support GUCY2C ligand supplementation as a novel disease prevention paradigm. With the recent FDA approval of the GUCY2C ligand, linaclotide, and two more synthetic ligands in the pipeline, this strategy can be tested in human trials. In addition to primary tumor prevention, we also review immunotherapies targeting GUCY2C expressed by metastatic lesions, and platforms using GUCY2C as a biomarker for detection and patient staging. Expert commentary: Results of the first GUCY2C targeting schemes in patients will become available in the coming years. The identification of GUCY2C ligand loss as a requirement for colorectal tumorigenesis has the potential to change the treatment paradigm from an irreversible disease of genetic mutation, to a treatable disease of ligand insufficiency

Temperature variations of the disorder-induced vortex-lattice melting landscape

Differential magneto-optical imaging of the vortex-lattice melting process in Bi_2Sr_2CaCu_2O_8 crystals reveals unexpected effects of quenched disorder on the broadening of the first-order phase transition. The melting patterns show that the disorder-induced melting landscape T_m(H,r) is not fixed, but rather changes dramatically with varying field and temperature along the melting line. The changes in both the scale and shape of the landscape are found to result from the competing contributions of different types of quenched disorder which have opposite effects on the local melting transition.Comment: 4 pages of text and 3 figures. Accepted for Publication in Physical Review Letter

How Does Retirement Planning Software Handle Postretirement Realities?

Many risks must be managed during the post-retirement period. This chapter explores retirement planning software that provides individuals and advisors the opportunity to perform a range of calculations to help them in retirement planning. We link results from surveys and research by the Society of Actuaries to show how the software handles post-retirement risks. We find that approaches to managing these risks are often not well-integrated