Желчнокаменная болезнь среди медицинского персонала поликлиники: факторы риска ее развития в разных профессиональных группах

The aim. Identification of risk factors for gallstone disease (GDS) development between different professional groups of polyclinic medical staff. Material and methods. 75 medical staff members were divided into two groups (1st group: 30 doctors; 2nd group: 45 nurses). All of them were interviewed fo r information about profession, gender, age, waist circumference (WC), body mass index (BMI), smoking, arterial hypertension (AH), diabetes mellitus (DM) and hypercholesterolemia. In addition, women were interviewed about the number of pregnancies, ostmenopause and taking oral contraceptive pills (OCPs). To assess physical activity, a short international questionnaire on physical activity (IPAQ) was used. To identify the presence of professional burnout (PB) syndrome we applied the Maslach Burnout Inventory (MBI) questionnaire, adapted by N.Е. Vodopianova for medical staff. At the final stage, the data of abdominal organs ultrasound examination were analyzed based on the materials of medical staff outpatient records. Results. The GSD prevalence among doctors was 33.3%, and 24.4% among nurses. In both groups age, AH, weight, WC and BMI contribute to GSD formation. In the first group of individuals with GSD, the level of total cholesterol (TC) was significantly higher. In the same group extremely high PB, postmenopause (p <0.05) and hypodynamia (p <0.1) were much more common. In the second group, there were more DM cases and pregnancies (p <0.05). Conclusion. The medical staff of the clinic has a high GSD incidence, whose frequency depends not only on classical risk factors prevalence, but is also determined by profession peculiarities, characterized by high psychological stress and lower physical activity of physicians, compared to nurses.Цель исследования. Выявить факторы риска развития желчнокаменной болезни (ЖКБ) среди медицинского персонала поликлиники в разных профессиональных группах. Материалы и методы. В поликлинике было осмотрено и анкетировано 75 медицинских сотрудников поликлиники, которые были разделены на две группы. В 1-ю были включены 30 врачей; во 2-ю - 45 медицинских сестер. Анализу подвергались такие показатели, как профессия, пол, возраст, объем талии (ОТ), индекс массы тела (ИМТ), курение, наличие артериальной гипертензии (АГ), сахарного диабета (СД), гиперхолестеринемии, постменопаузы; у женщин – количество беременностей и прием оральных контрацептивов (ОК). Для оценки физической активности применяли краткий международный опросник по физической активности (IPAQ). Для выявления симптомов профессионального выгорания (ПВ) использовали опросник Maslach Burnout Inventory (MBI), адаптированный Н.Е. Водопьяновой для медицинских сотрудников. На конечном этапе анализировались данные ультразвукового исследования органов брюшной полости по амбулаторным картам медицинских работников. Результаты. Распространенность ЖКБ среди врачей составила 33,3%, и 24,4% среди медицинских сестер. В обеих группах на формирование ЖКБ влияют возраст, наличие АГ, вес, ОТ, ИМТ. В первой группе лиц с ЖКБ уровень общего холестерина был достоверно выше (ОХ). В этой же группе ПВ крайне высокой степени, постменопауза (p<0,05) и гиподинамия (p<0,1) встречались значительно чаще. В группе медицинских сестер с ЖКБ отмечалось преобладание лиц с СД и большее число беременностей (p<0,05). Заключение. У медицинского персонала поликлиники имеет место высокая распространенность ЖКБ, частота которой зависит не только от распространенности классических факторов риска, но и определяется особенностями профессиональной деятельности, характеризующейся высокой психологической нагрузкой и более низкой физической активностью врачебного персонала, по сравнению с медицинскими сестрами

Circulating markers of vascular damage as predictors of cardiovascular events in atherosclerosis and metabolic disorders

The article presents the results of cluster analysis of the contribution of immune inflammation and endothelial dysfunction (ED) markers to the frequency and severity of cardiovascular events (CVE) in cohorts of patients with asymptomatic atherosclerosis (AAS), coronary artery disease (CAD), type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS) during a 3-year prospective observation. Results Circulating markers of ED and immune inflammation, such as ET-1, IL-1β, TNF-α, antibodies to collagen type I and III, and antibodies to chondroitine sulfate (CS) contribute to cardiovascular (CV) manifestation in AAS. In CAD patients ET-1, eNOs, antibodies to collagen, as well as IL-6 and vWf  are the main contributors. In T2DM without clinical manifestation of CAD, the set of markers associated with the adverse events includes ET-1, eNOs, IL-6, anti-C, and anti-HA. In CAD combined with T2DM, the cluster of markers associated with the adverse events includes vWf, TNF-α, eNOs, IL-6, anti-C, anti-HA and CRP. In AAS without MS, the key contributors are ET-1 and vWf, and the presence of anti-C and anti-ChS; in AAS/MS patients, the key markers are IL-1β, TNF-α, anti-C, anti-ChS, anti-HA, and CRP. In CAD without MS, the cluster of markers associated with adverse events includes ET-1, eNOs and anti-HA; in CAD/MS it includes anti-C, ET-1, and IL-6. Conclusion. The obtained results confirm the role of systemic inflammation in the development of atherosclerosis-associated angiopathy in coronary pathology and disorders of carbohydrate metabolism, and also suggest a set of circulating markers as predictors of adverse CVE

Thyroid hormones imbalance in patients with functional dyspepsia

© 2018, Pharmainfo Publications. All rights reserved. The article presents the results of our research into the analysis of the thyroid dysfunction role in the pathogenesis and clinical manifestations of functional dyspepsia (FD). It was revealed that 31% of patients with FD had a T3 and/or FT4 level drop at normal or moderately reduced levels of TSH in the blood, which corresponds to the notion of euthyroid pathology syndrome. These changes in the thyroid hormones level were more often found in the postprandial FD case than in the one with epigastric pain syndrome. Besides this, FD patients had a rise in the average level of antithyroid antibodies compared to the healthy controls. A direct relationship was discovered between the degree of FD clinical signs and thyroid system functional disorders. The results obtained allow us to make a conclusion concerning the significance of thyroid hormones imbalance in FD pathogenesis and clinical picture

“ARMAN” archaea depend on association with euryarchaeal host in culture and in situ

AbstractIntriguing, yet uncultured ‘ARMAN’-like archaea are metabolically dependent on other members of the microbial community. It remains uncertain though which hosts they rely upon, and, because of the lack of complete genomes, to what extent. Here, we report the co-culturing of ARMAN-2-related organism, Mia14, with Cuniculiplasma divulgatum PM4 during the isolation of this strain from acidic streamer in Parys Mountain (Isle of Anglesey, UK). Mia14 is highly enriched in the binary culture (ca. 10% genomic reads) and its ungapped 0.95 Mbp genome points at severe voids in central metabolic pathways, indicating dependence on the host, C. divulgatum PM4. Analysis of C. divulgatum isolates from different sites and shotgun sequence data of Parys Mountain samples suggests an extensive genetic exchange between Mia14 and hosts in situ. Within the subset of organisms with high-quality genomic assemblies representing the ‘DPANN’ superphylum, the Mia14 lineage has had the largest gene flux, with dozens of genes gained that are implicated in the host interaction.</jats:p

Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project

Personalized nutrition is of increasing interest to individuals actively monitoring their health. The relations between the duration of diet intervention and the effects on gut microbiota have yet to be elucidated. Here we examined the associations of short-term dietary changes, long-term dietary habits and lifestyle with gut microbiota. Stool samples from 248 citizen-science volunteers were collected before and after a self-reported 2-week personalized diet intervention, then analyzed using 16S rRNA sequencing. Considerable correlations between long-term dietary habits and gut community structure were detected. A higher intake of vegetables and fruits was associated with increased levels of butyrate-producing Clostridiales and higher community richness. A paired comparison of the metagenomes before and after the 2-week intervention showed that even a brief, uncontrolled intervention produced profound changes in community structure: resulting in decreased levels of Bacteroidaceae, Porphyromonadaceae and Rikenellaceae families and decreased alpha-diversity coupled with an increase of Methanobrevibacter, Bifidobacterium, Clostridium and butyrate-producing Lachnospiraceae- as well as the prevalence of a permatype (a bootstrapping-based variation of enterotype) associated with a higher diversity of diet. The response of microbiota to the intervention was dependent on the initial microbiota state. These findings pave the way for the development of an individualized diet.</p

Interaction of health and religion in the modern world ways of rapprochement

© 2019, Ecozone, OAIMDD. All rights reserved. Spirituality is the fourth aspect of health, along with the physical, mental and social ones. At the same time, religiosity is a private manifestation of spirituality. The purpose of the study is to find out the relationship between health care on the one hand, and spirituality, religious life, a subjective feeling of happiness and good health indicators, on the other. A review of literary sources shows that positive values, beliefs, and the power of faith contribute to health and happiness. Religious participation and spiritual practices have a positive effect on the survival of the sick, low disease incidence, prolonged remissions of chronic diseases, lower anxiety and depression level, healthy lifestyle and compliance. At the same time, better results in treating patients are achieved when doctors and patients have common spiritual and/or religious attitudes

Interaction of health and religion in the modern world ways of rapprochement

© 2019, Ecozone, OAIMDD. All rights reserved. Spirituality is the fourth aspect of health, along with the physical, mental and social ones. At the same time, religiosity is a private manifestation of spirituality. The purpose of the study is to find out the relationship between health care on the one hand, and spirituality, religious life, a subjective feeling of happiness and good health indicators, on the other. A review of literary sources shows that positive values, beliefs, and the power of faith contribute to health and happiness. Religious participation and spiritual practices have a positive effect on the survival of the sick, low disease incidence, prolonged remissions of chronic diseases, lower anxiety and depression level, healthy lifestyle and compliance. At the same time, better results in treating patients are achieved when doctors and patients have common spiritual and/or religious attitudes

Thyroid hormones imbalance in patients with functional dyspepsia

© 2018, Pharmainfo Publications. All rights reserved. The article presents the results of our research into the analysis of the thyroid dysfunction role in the pathogenesis and clinical manifestations of functional dyspepsia (FD). It was revealed that 31% of patients with FD had a T3 and/or FT4 level drop at normal or moderately reduced levels of TSH in the blood, which corresponds to the notion of euthyroid pathology syndrome. These changes in the thyroid hormones level were more often found in the postprandial FD case than in the one with epigastric pain syndrome. Besides this, FD patients had a rise in the average level of antithyroid antibodies compared to the healthy controls. A direct relationship was discovered between the degree of FD clinical signs and thyroid system functional disorders. The results obtained allow us to make a conclusion concerning the significance of thyroid hormones imbalance in FD pathogenesis and clinical picture