13 research outputs found

    PRECISION CASTING INTO DISPOSABLE CERAMIC MOLD – A HIGH EFFICIENCY METHOD OF PRODUCTION OF CASTINGS OF IRREGULAR SHAPE

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    The article shows the advantages and disadvantages of precision casting into disposable ceramic molds. The high quality shaped castings produced by modernized ceramic molding process are proved the reliability and prospects of this advanced technology

    Гетерологическая экспрессия, выделение и физико-химические свойства рекомбинантного цитохрома CYP1B1 человека

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    In order to study the catalytic properties of CYP1B1 toward a number of steroid compounds, we have developed an effective system of heterologous expression of hemoprotein in E.coli and isolated the preparation of recombinant CYP1B1 «soluble» form in a highly purified state. The interaction parameters of the purified enzyme with steroid ligands have been determined.С целью изучения каталитических свойств СYP1B1 по отношению к ряду стероидных соединений нами разработана эффективная система гетерологической экспрессиии гемопротеида в E.coli и выделен в высокоочищенном состоянии «растворимый» препарат рекомбинантного CYP1B1. Установлены параметры взаимодействия данного фермермента с стероидными лигандами

    Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy

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    This study aims to describe the ophthalmic characteristics of autosomal dominant (AD) WFS1-associated optic atrophy (AD WFS1-OA), and to explore phenotypic differences with dominant optic atrophy (DOA) caused by mutations in the OPA1-gene. WFS1-associated diseases, or 'wolframinopathies', exhibit a spectrum of ocular and systemic phenotypes, of which the autosomal recessive Wolfram syndrome has been the most extensively studied. AD mutations in WFS1 also cause various phenotypical changes including OA. The most common phenotype in AD WFS1-associated disease, the combination of OA and hearing loss (HL), clinically resembles the 'plus' phenotype of DOA. We performed a comprehensive medical record review across tertiary referral centers in the Netherlands and Belgium resulting in 22 patients with heterozygous WFS1 variants. Eighteen (82%) had HL in addition to OA. Diabetes mellitus was found in 7 (32%). Four patients had isolated OA. One patient had an unusual phenotype with anterior chamber abnormalities and malformations of the extremities. Compared to DOA, AD WFS1-OA patients had different color vision abnormalities (red-green vs blue-yellow in DOA), abnormal OPL lamination on macular OCT (absent in DOA), more generalized thinning of the retinal nerve fiber layer, and more reduced and delayed pattern reversal visual evoked potentials.</p

    КОНСТРУКЦИЯ И АЛГОРИТМ РАБОТЫ ЛАЗЕРНОГО КОМБИНИРОВАННОГО ПОЖАРНОГО ИЗВЕЩАТЕЛЯ

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    The point optical smoke detector is currently the most effective means of fire detection at the early stage of its occurrence. The urgent task for this type of detector is to increase its sensitivity to «black» smoke and ensure resilience to the effects of electromagnetic interference and particle smoke origin.The objective of this work is to develop a structure and algorithm of point combined fire detector that provides high sensitivity to various types of fumes, detection rate and high noise immunity. The decision of the current objective is carried out using the proposed optical scheme of the dual-channel devices of smoke detection (for control of the radiation intensities scattered by smoke particles and passed through the smoke).The design and algorithm of the combined fire detector comprising a dual-channel laser device of smoke detection and carbon monoxide detector is developed.The results of the made detector tests indicate about its increased in comparison with the conventional single-channel point smoke fire detector sensitivity to various types of fumes and detection rate of fires. The high functional characteristics of the detector are provided with application additional channel of smoke detection (to intensity change of transmitted radiation through it) created by the requirements for unrestricted entry of smoke in the area of control and effective algorithm for processing of recorded signals. Точечный оптический дымовой пожарный извещатель остается в настоящее время наиболее эффективным средством обнаружения пожара на ранней стадии его появления. Актуальной задачей для данного типа извещателя является повышение его чувствительности к «черным» дымам и обеспечение устойчивости к воздействию электромагнитных помех и частиц не дымового происхождения. Целью настоящей работы являлась разработка конструкции и алгоритма работы точечного комбинированного пожарного извещателя, обеспечивающего высокую чувствительность к различным типам дымов, скорость их обнаружения и высокую помехоустойчивость.Решение поставленной цели осуществлено использованием предложенной оптической схемы двухканального устройства обнаружения дыма (по контролю интенсивностей излучения, рассеянного частицами дыма и прошедшего через дым).Разработана конструкция и алгоритм работы комбинированного пожарного извещателя, включающего двухканальное лазерное устройство обнаружения дыма и датчик угарного газа.Результаты тестовых испытаний изготовленного извещателя свидетельствуют о его повышенной в сравнении с обычным одноканальным точечным дымовым пожарным извещателем чувствительности к различным типам дымов и скорости обнаружения возгораний. Высокие функциональные характеристики извещателя обеспечиваются применением дополнительного канала обнаружения дыма (по изменению интенсивности проходящего через него излучения), созданными условиями беспрепятственного захода дыма в зону контроля и эффективным алгоритмом обработки регистрируемых сигналов.

    USE OF TECHNOLOGY OF PRECISION CASTING INTO DISPOSABLE CERAMIC MOLD FOR PRODUCTION OF SHAPED CASTINGS AND OF CASTINGS WITH THE HIGHER PERFORMANCE REQUIREMENTS

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    Through the example of production of specific castings the effectiveness of the precision ceramic molding technology for the production of shaped castings and castings with the higher performance requirements has been demonstrated

    СONSTRUCTION AND THE ALGORITHM OPERATION OF THE LASER COMBINED FIRE DETECTOR

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    The point optical smoke detector is currently the most effective means of fire detection at the early stage of its occurrence. The urgent task for this type of detector is to increase its sensitivity to «black» smoke and ensure resilience to the effects of electromagnetic interference and particle smoke origin.The objective of this work is to develop a structure and algorithm of point combined fire detector that provides high sensitivity to various types of fumes, detection rate and high noise immunity. The decision of the current objective is carried out using the proposed optical scheme of the dual-channel devices of smoke detection (for control of the radiation intensities scattered by smoke particles and passed through the smoke).The design and algorithm of the combined fire detector comprising a dual-channel laser device of smoke detection and carbon monoxide detector is developed.The results of the made detector tests indicate about its increased in comparison with the conventional single-channel point smoke fire detector sensitivity to various types of fumes and detection rate of fires. The high functional characteristics of the detector are provided with application additional channel of smoke detection (to intensity change of transmitted radiation through it) created by the requirements for unrestricted entry of smoke in the area of control and effective algorithm for processing of recorded signals

    Spin Polarimetry and Magnetic Dichroism on a Buried Magnetic Layer Using Hard X-ray Photoelectron Spectroscopy

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    The spin-resolved electronic structure of buried magnetic layers is studied by hard X-ray photoelectron spectroscopy (HAXPES) using a spin polarimeter in combination with a high-energy hemispherical electron analyzer at the high-brilliance BL47XU beamline (SPring-8, Japan). Spin-resolved photoelectron spectra are analyzed in comparison with the results of magnetic linear and circular dichroism in photoelectron emission in the case of buried Co2FeAl0.5Si0.5 layers. The relatively large inelastic mean free path (up to 20 nm) of fast photoelectrons enables us to extend the HAXPES technique with electron-spin polarimetry and to develop spin analysis techniques for buried magnetic multilayers and interfaces. (C) 2012 The Japan Society of Applied Physic
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