A New Family of Planets ? "Ocean Planets"

A new family of planets is considered which is between rochy terrestrial planets and gaseous giant ones: "Ocean-Planets". We present the possible formation, composition and internal models of these putative planets, including that of their ocean, as well as their possible Exobiology interest. These planets should be detectable by planet detection missions such as Eddington and Kepler, and possibly COROT (lauch scheduled in 2006). They would be ideal targets for spectroscopic missions such as Darwin/TPF.Comment: 15 pages, 3 figures submitted to Icarus notes (10 july 2003

A search for flares and mass ejections on young late-type stars in the open cluster Blanco-1

We present a search for stellar activity (flares and mass ejections) in a sample of 28 stars in the young open cluster Blanco-1. We use optical spectra obtained with ESO's VIMOS multi-object spectrograph installed on the VLT. From the total observing time of $\sim$ 5 hours, we find four H$\alpha$ flares but no distinct indication of coronal mass ejections (CMEs) on the investigated dK-dM stars. Two flares show "dips" in their light-curves right before their impulsive phases which are similar to previous discoveries in photometric light-curves of active dMe stars. We estimate an upper limit of $<$4 CMEs per day per star and discuss this result with respect to a semi- empirical estimation of the CME rate of main-sequence stars. We find that we should have detected at least one CME per star with a mass of 1-15$\times10^{16}$ g depending on the star's X-ray luminosity, but the estimated H$\alpha$ fluxes associated with these masses are below the detection limit of our observations. We conclude that the parameter which mainly influences the detection of stellar CMEs using the method of Doppler-shifted emission caused by moving plasma is not the spectral resolution or velocity but the flux or mass of the CME.Comment: Accepted for publication in MNRAS, accepted 2014 June 10, received 2014 June 5, in original form 2014 March 24, 14 pages, 5 figure

Pharmacokinetic analysis after implantation of everolimus-eluting self-expanding stents in the peripheral vasculature

Background: A novel self-expanding drug-eluting stent was designed to release everolimus 225 mu g/cm(2) to prevent restenosis following peripheral arterial intervention. The purpose of this study was to measure the pharmacokinetic profile of everolimus following stent implantation. Methods: One hundred four patients with symptomatic peripheral arterial disease underwent implantation of everolimus-eluting stents in the femoropopliteal arteries. In a prespecified subset of 26 patients, blood samples for assay of everolimus content were collected prior to stent implantation, at 1, 4, and 8 hours postprocedure, prior to discharge, and at 1 month postproccdure. Results: A total of 39 stents, ranging from 28 mm to 100 mm in length, were implanted in 26 patients, resulting in a total delivered everolimus dose range of 3.0 to 7.6 mg. Following the procedure, the maximum observed everolimus blood concentrations (C-max) varied from 1.83 +/- 0.05 ng/mL after implantation of a single 80-mm stent to 4.66 +/- 1.78 ng/mL after implantation of two 100-mm stents. The mean time to peak concentration (T-max) varied from 6.8 hours to 35 hours. The pharmacokinetics of everolimus were dose-proportional in that dose-normalized C-max and area under the curve values were constant over the studied dose range. Conclusions: After implantation of everolimus-eluting self-expanding stents in the femoropopliteal arteries, systemic blood concentrations of everolimus are predictable and considerably lower than blood concentrations observed following safe oral administration of everolimus

Double tailed scorpiand-type calix[10]phyrin: Synthesis and proton-driven anion recognition features

Reported here is a large oligopyrrole macrocycle, a calix[10]phyrin bearing two diformyl substituents. The combination of conjugation provided by two pentapyrrolic subunits and flexibility resulting from the presence of sp3 hybridized meso bridges allows the system to adopt a double tailed, scorpiand-like structure with two near-symmetric binding pockets. In methanol solution, this macrocycle was found to interact with a number of test acids, including sulfuric acid, trifluoroacetic acid, phosphoric acid, hydrochloric acid, and fluoroboric acid, via a combination of protonation and counter anion binding. Species specific behavior was seen, allowing for the colorimetric-based discrimination between the acids. Efforts to model the underlying binding equilibria led to the conclusion that upon treatment with excess H2SO4, up to four protons and two counteranions are bound, whereas in the case of HCl the dominant species is a monoanionic complex. The responses of several other acids were rationalized in terms of these limiting scenarios